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Black Pooling Project

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00064480
Recruitment Status : Completed
First Posted : July 10, 2003
Last Update Posted : May 15, 2018
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To conduct a person-level meta-analysis by pooling 9 United States studies with both black and white cohorts.

Condition or disease
Cardiovascular Diseases Coronary Disease Heart Diseases

Detailed Description:


Over the last three decades a sustained and marked decline in death rates from coronary heart disease (CHD) has occurred for all major demographic groups of the US population. Recently, however, the decline has proceeded less rapidly in blacks than in whites, and in women than men. These trends have focused further attention on possible heterogeneity in the risk factor patterns among the demographic sub-groups. As is well recognized, the knowledge on CHD risk factors and statistical models used to predict personal risk of CHD have been based on studies among white populations. In some epidemiological studies with samples from black populations, large variation in the effect of specific factors has been noted. Given the small sample of blacks under investigation, however, low statistical power exists for many of the black-white comparisons. The fundamental obstacle to progress in this area remains the absence of the cohorts of sufficient size that is representative of all four major groups. Hence, a strong rationale exists to undertake a "pooling project" to clarify a set of important unanswered questions in cardiovascular disease epidemiology.


Person-level meta-analysis will be conducted by pooling 9 large United States epidemiologic studies with both black and white samples: the First National Health and Nutrition Examination Survey (NHANES I) Epidemiological Follow-up Study, the NHANES II Mortality Follow-up Study, the Charleston Heart Study, the Evans County Heart Study, the Chicago Heart Association Detection Project in Industry, the Atherosclerosis Risk in Communities Study (ARIC), the Follow-up Study of the screenees for the Multiple Risk Factors Intervention Trial (MRFIT), the Follow-up Study of the participants from the MRFIT, and the Follow-up Study of the participants from the Hypertension Detection and Follow-up Program (HDFP). Black-white comparison will be performed on the CHD incidence and mortality, exposure-outcome relationship, patterns of co-morbidity (or coexistence of risk factors) and population attributable risk. Multivariate risk functions will also be examined in blacks and whites in the three contexts: ordering risk, magnitude of relative risks, and estimation of absolute risk.

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Study Type : Observational
Study Start Date : July 2003
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00064480

Sponsors and Collaborators
Medical University of South Carolina
National Heart, Lung, and Blood Institute (NHLBI)
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OverallOfficial: Daniel Lackland Medical University of South Carolina

Layout table for additonal information Identifier: NCT00064480    
Other Study ID Numbers: 1222
R01HL072377 ( U.S. NIH Grant/Contract )
First Posted: July 10, 2003    Key Record Dates
Last Update Posted: May 15, 2018
Last Verified: April 2008
Additional relevant MeSH terms:
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Heart Diseases
Coronary Disease
Cardiovascular Diseases
Myocardial Ischemia
Vascular Diseases