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Antisocial Behavior: Passing From Parent to Child to Grandchild

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00060788
Recruitment Status : Unknown
Verified March 2006 by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Recruitment status was:  Recruiting
First Posted : May 14, 2003
Last Update Posted : March 7, 2006
Information provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Brief Summary:
Antisocial behavior often occurs in different generations within the same family. However, it is not known what factors contribute to this passing of antisocial behavior from parent to child to grandchild. This study is part of a project evaluating antisocial behavior in families; it focuses on the passage of such behavior from one generation to the next.

Condition or disease
Dyssocial Behavior Antisocial Personality Disorder

Detailed Description:

While it is well-known that antisocial behavior runs in families, little is known about the specific mechanisms by which it is transmitted from one generation to the next. This prospective study will examine biological influences on transgenerational continuity and change, and how biology interacts with social factors in modulating the transmission of antisocial behavior. The study is unique in that it includes both mothers and fathers, focuses on early mechanisms, and addresses female as well as male antisocial behavior.

This study is part of the continuing Mauritius Child Health Project. The project began by testing 1,795 children age 3 years old on psychophysiological, behavioral, nutritional, and cognitive measures. Both male and female children were tested. Their parents were also assessed for psychosocial influences. One hundred children then participated in a nutritional, exercise, and educational enrichment intervention from ages 3 to 5 years old. The intervention has been shown to increase physiological arousal and attention at age 11 years and to reduce conduct disorder at age 17 years.

These 3-year-old children are now 30-year-old adults. This study will retest these adults on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Their previously untested spouses will also be assessed. Finally, many of these adults now have 3-year-old children of their own; these children will be evaluated as well. Measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior will be assessed. Data from the enrichment cohort will be evaluated to determine if the intervention disrupted the intergenerational transmission of antisocial behavior from the second to third generations.

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Study Type : Observational
Enrollment : 663 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Intergenerational Transmission of Antisocial Behavior
Study Start Date : September 2001
Study Completion Date : December 2005

Information from the National Library of Medicine

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Ages Eligible for Study:   36 Months to 48 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Child of a participant tested in previous Mauritius Child Health Project studies

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00060788

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Joint Child Health Project Recruiting
Quatre Bornes, Mauritius
Contact: Hughon Sophie, B.A.    230-453-9123      
Sponsors and Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
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Principal Investigator: Adrian Raine University of Southern California
Layout table for additonal information Identifier: NCT00060788    
Other Study ID Numbers: 1R01HD42259-1
First Posted: May 14, 2003    Key Record Dates
Last Update Posted: March 7, 2006
Last Verified: March 2006
Keywords provided by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):
Antisocial behavior
Mauritius Child Health Project
Intergenerational transmission
Additional relevant MeSH terms:
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Personality Disorders
Antisocial Personality Disorder
Mental Disorders