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Effectiveness of Binge Eating Disorder Treatments

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00060762
Recruitment Status : Completed
First Posted : May 13, 2003
Last Update Posted : May 15, 2014
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Stanford University

Brief Summary:
This study will evaluate the long-term effectiveness of interpersonal psychotherapy, behavioral weight loss interventions, and guided self help treatments in treating binge eating disorder (BED).

Condition or disease Intervention/treatment Phase
Eating Disorders Behavioral: Interpersonal Therapy Behavioral: Behavioral Weight Loss Treatment Behavioral: Guided Self Help Phase 4

Detailed Description:

BED is a serious condition that is associated with psychiatric comorbidity, psychosocial impairment, and obesity. Interpersonal psychotherapy (IPT), behavioral weight loss (BWL) interventions, and guided self help (GSH) treatments for BED have been evaluated, but the safest and most effective treatment has not yet been identified. This study will determine which of these three treatments is most effective in treating BED.

Participants are stratified by negative affect subtype and are randomly assigned for 6 months to one of three treatment groups: IPT, BWL, or GSH. IPT focuses on current interpersonal problems which are hypothesized to increase negative affect and lead to binge eating. BWL interventions involve the adoption of weight loss inducing behaviors. GSH is a shortened version of cognitive behavioral therapy that focuses directly on eating behavior. IPT and BWL patients have 20 treatment sessions; those receiving GSH have 10 sessions. Assessments are made pre-treatment, post-treatment, and at 6, 12, 18, and 24 months after treatment is complete.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 205 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effectiveness of Psychological Treatments for BED
Study Start Date : April 2002
Actual Primary Completion Date : March 2007
Actual Study Completion Date : March 2007

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Interpersonal Therapy
Interpersonal Therapy is a psychotherapy aimed at resolving interpersonal difficulties
Behavioral: Interpersonal Therapy
20 sessions of interpersonal therapy were provided over a 6-month period
Other Name: IPT

Active Comparator: Behavioral Weight Loss Treatment
Behavioral Weight Loss Treatment is aimed solely at weight loss, however it has been shown to decrease binge eating
Behavioral: Behavioral Weight Loss Treatment
20 sessions of behavioral weight loss treatment were provided over a 6-month period
Other Name: BWL; Weight loss treatment

Active Comparator: Guided Self Help
Guided Self-Help is a brief psychotherapy based on cognitive-behavioral treatment
Behavioral: Guided Self Help
10 sessions of guided self help were provided over a 6-month period
Other Name: GSH

Primary Outcome Measures :
  1. Binge eating [ Time Frame: Pre-treatment, 6, 12, and 24-months ]
    Rate of binge eating

Secondary Outcome Measures :
  1. Eating disorder psychopathology [ Time Frame: pre-treatment, 6, 12, 24 months ]
    Assessed by the Eating Disorder Examination

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • DSM-IV criteria for Binge Eating Disorder
  • Body Mass Index (BMI) between 27 and 45

Exclusion criteria:

  • Body Mass index > 45
  • Current psychosis
  • Current bipolar disorder
  • Alcohol or drug dependence within last 6-months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00060762

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United States, California
W. Stewart Agras
Stanford, California, United States, 94305
United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63100
United States, New Jersey
Rutgers University Eating Disorder Clinic
Piscataway, New Jersey, United States, 08854
Sponsors and Collaborators
Stanford University
National Institute of Mental Health (NIMH)
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Study Director: William S Agras, MD Stanford University
Publications of Results:
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Responsible Party: Stanford University Identifier: NCT00060762    
Other Study ID Numbers: R01MH063863 ( U.S. NIH Grant/Contract )
R01MH063863 ( U.S. NIH Grant/Contract )
First Posted: May 13, 2003    Key Record Dates
Last Update Posted: May 15, 2014
Last Verified: May 2014
Keywords provided by Stanford University:
Weight Loss
Additional relevant MeSH terms:
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Feeding and Eating Disorders
Mental Disorders