Genetic Study of Familial Factors in Patients With Colon Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00055848|
Recruitment Status : Completed
First Posted : March 7, 2003
Last Update Posted : July 13, 2016
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer.
PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.
|Condition or disease||Intervention/treatment|
|Colorectal Cancer||Genetic: cytogenetic analysis Genetic: gene mapping Genetic: microarray analysis|
- Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps.
- Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients.
- Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients.
- Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.
|Study Type :||Observational|
|Actual Enrollment :||600 participants|
|Official Title:||Familial Factors in the Development of Colon Cancer|
|Study Start Date :||December 2001|
|Actual Primary Completion Date :||October 2010|
|Actual Study Completion Date :||October 2010|
Patients donate blood samples for analysis of colorectal susceptibility genes. Patients also complete a questionnaire regarding family cancer history.
A certificate of confidentiality protecting the identity of research participants in this project has been issued by the National Cancer Institute.
Participants do not receive the results of the genetic testing, and the results do not influence the type or duration of treatment.
Genetic: cytogenetic analysis
Genetic: gene mapping
Genetic: microarray analysis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00055848
|United States, North Carolina|
|Wayne Memorial Hospital, Incorporated|
|Goldsboro, North Carolina, United States, 27534|
|Study Chair:||Monica M. Bertagnolli, MD||Dana-Farber/Brigham and Women's Cancer Center|