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Organophosphate Pesticides and Human Reproductive Health

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00046124
Recruitment Status : Completed
First Posted : September 23, 2002
Last Update Posted : September 4, 2006
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
This prospective cohort study assesses the effects of exposure to organophosphate (OP) pesticides on adverse reproductive outcomes in both male and female agricultural workers in China. We will enroll women and their spouses, who are attempting to become pregnant, and observe reproductive endpoints including (1) semen parameters (concentration, total count, motility, progression and morphology), (2) menstrual disorders (oligomenorrhea, amenorrhea, polymenorrhea, intermenstrual bleeding, prolonged menstrual bleeding, dysmenorrhea, and irregular menstruation); (3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP) in women and abnormalities of LH, FSH, TSH, SHBG, inhibin-B and testosterone in men; (4) fecundability; and (5) pregnancy outcomes including spontaneous abortion, preterm delivery, low birth weight, and intrauterine growth retardation.

Condition or disease
Fecundability Spermatazoa Disorders Menstruation Disorders Endocrine Dysfunction

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Study Type : Observational
Observational Model: Defined Population
Time Perspective: Prospective

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pesticides

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 34 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • it must be the first marriage for both the woman and her husband and they must currently live in the study area;
  • the female's age must range from 20 to 34 years;
  • the couple has no plan to leave the study area in which they live for the next two years.

Exclusion Criteria:

  • those who are currently pregnant;
  • those who have tried unsuccessfully to get pregnant for at least 1 year;
  • those who are current or former smokers;
  • those who plan to move in the coming year.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00046124

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China, Anhui
Anhui Medical University
Anqing City, Anhui, China
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Layout table for additonal information Identifier: NCT00046124    
Other Study ID Numbers: 8957-CP-001
First Posted: September 23, 2002    Key Record Dates
Last Update Posted: September 4, 2006
Last Verified: September 2006
Additional relevant MeSH terms:
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Menstruation Disturbances
Pathologic Processes