Study of Factors Regulating Mast Cell Proliferation
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|ClinicalTrials.gov Identifier: NCT00044122|
Recruitment Status : Recruiting
First Posted : August 19, 2002
Last Update Posted : August 15, 2019
This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body. These cells can release chemicals that cause itching, blisters, flushing, bone pain and abdominal pain.
Patients up to 80 years of age with mastocytosis may be eligible for this 1-day study. Participants will have one visit at NIH lasting up to 8 hours, during which they will undergo the following tests and procedures:
- Medical history and physical examination.
- Laboratory studies, if medically indicated.
- Blood tests to identify genetic changes important in the growth, development, and functioning of mast cells.
- Bone marrow aspiration and biopsy.
For the bone marrow procedure, the skin over the hipbone and the outer surface of the bone itself are numbed with local anesthesia. Then, a special needle is inserted into the hipbone and about 1 tablespoon of bone marrow is drawn into a syringe. Another needle is inserted into the same area to collect a small piece of the bone marrow. Additional procedures may include allergen testing, urinalysis, and 24-hour urine collection.
Participants will receive an evaluation of their mastocytosis.
|Condition or disease|
|Mastocytosis Monoclonal Bone Marrow Tryptase|
|Study Type :||Observational|
|Estimated Enrollment :||550 participants|
|Official Title:||Regulation of the Proliferation and Survival of Normal and Neoplastic Human Mast Cells|
|Actual Study Start Date :||September 18, 2002|
Relatives of patient with mastocytosis
Adults with Mastocytosis
Adults with documented mastocytosis
Pediatric Patients with Mastocytosis
Pediatric patient with documented mastocytosis
Pediatric relatives of patients with mastocytosis
- To obtain normal and neoplastic human mast cells from the bone marrow and peripheral blood of patients with mastocytosis in order to study the regulation of the proliferation and survival of these cells, and to assess the extent and classific... [ Time Frame: Patients return to NIH as necessary ]continuing collection of cells from subjects with mastocytosis for ongoing experimentation in laboratory
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00044122
|Contact: Robin R. Eisch, R.N.||(301) firstname.lastname@example.org|
|Contact: Dean D Metcalfe, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Dean D Metcalfe, M.D.||National Institute of Allergy and Infectious Diseases (NIAID)|