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S0200 Carboplatin With or Without Doxil in Patients With Recurrent Ovarian Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00043082
Recruitment Status : Completed
First Posted : January 27, 2003
Last Update Posted : October 26, 2015
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Southwest Oncology Group

Brief Summary:

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known if carboplatin is more effective with or without liposomal doxorubicin in treating recurrent ovarian epithelial or primary peritoneal cancer.

PURPOSE: Randomized phase III trial to determine the effectiveness of carboplatin with or without liposomal doxorubicin in treating patients who have recurrent ovarian epithelial or primary peritoneal cancer.

Condition or disease Intervention/treatment Phase
Ovarian Cancer Peritoneal Cavity Cancer Drug: carboplatin Drug: pegylated liposomal doxorubicin hydrochloride Phase 3

Detailed Description:


  • Compare overall survival of patients with platinum-sensitive recurrent ovarian epithelial or primary peritoneal cancer treated with carboplatin with or without pegylated doxorubicin HCl liposome.
  • Compare progression-free survival, confirmed complete response rates, and time to treatment failure in patients treated with these regimens.
  • Compare the toxicity of these regimens in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to disease measurability (elevated CA 125 only vs nonmeasurable disease only with or without elevated CA 125 vs measurable disease), number of disease sites (2 or fewer vs 3 or more), and serous tumor histology (yes vs no). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive carboplatin IV over 15 minutes and pegylated doxorubicin HCl liposome IV over 1 hour on day 1.
  • Arm II: Patients receive carboplatin IV as in arm I. Treatment in both arms repeats every 4 weeks for a total of 15 courses in the absence of disease progression or unacceptable toxicity.

Patients are followed at 4 weeks, every 6 months for 3 years, and then annually for 7 years.

PROJECTED ACCRUAL: A total of 900 patients will be accrued for this study within 4 years.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 61 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase III Study of Liposomal Doxorubicin Plus Carboplatin Versus Carboplatin in Platinum-Sensitive Patients With Recurrent Epithelial Ovarian and Peritoneal Carcinoma After Failure of Initial Platinum-Based Chemotherapy
Study Start Date : August 2002
Actual Primary Completion Date : June 2007
Actual Study Completion Date : July 2011

Arm Intervention/treatment
Experimental: carboplatin and doxorubicin
carboplatin and liposomal doxorubicin given q 4 weeks
Drug: carboplatin
intravenous q 4 weeks

Drug: pegylated liposomal doxorubicin hydrochloride
intravenous q 4 weeks

Active Comparator: carboplatin
carboplatin alone
Drug: carboplatin
intravenous q 4 weeks

Primary Outcome Measures :
  1. overall survival [ Time Frame: ten years ]
    From date of registration to date of death

Secondary Outcome Measures :
  1. progression free survival and response [ Time Frame: 10 years ]
    response by RECIST criteria

  2. side effects [ Time Frame: 15 months ]
    side effects described per NCI CTC version 2.0

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 120 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No


  • Histologically confirmed ovarian epithelial carcinoma

    • Stage III or IV disease at time of initial staging laparotomy
  • Primary peritoneal and mixed Mullerian tumors allowed
  • No borderline ovarian tumors
  • Disease progression or recurrence after a progression-free and platinum-free interval of 6-24 months after completion of first-line platinum-based chemotherapy (either single agent or combination therapy)
  • Disease progression or recurrence based solely on CA 125 elevation allowed, provided that one of the following is true:

    • Prior baseline CA 125 greater than 35 U/mL and subsequent normalization of no greater than 35 U/mL must have CA 125 greater than 2 times upper limit of normal (ULN) on 2 occasions at least 1 week apart
    • Prior baseline CA 125 greater than 35 U/mL that never normalized must have CA 125 greater than 2 times the nadir value on 2 occasions at least 1 week apart
    • Prior normal baseline CA 125 (no greater than 35 U/mL) must show CA 125 greater than 2 times ULN on 2 occasions at least 1 week apart
  • No known brain metastases



  • Not specified

Performance status

  • Zubrod 0-1

Life expectancy

  • Not specified


  • Absolute neutrophil count at least 1,500/mm^3
  • Platelet count at least 100,000/mm^3
  • Hemoglobin at least 10 g/dL


  • SGOT and/or SGPT no greater than 2 times upper limit of normal (ULN)
  • Alkaline phosphatase no greater than 2 times ULN
  • Bilirubin no greater than ULN


  • Creatinine no greater than 1.9 mg/dL


  • No New York Heart Association class II-IV cardiac disease
  • No clinical evidence of congestive heart failure
  • Ejection fraction greater than 50% by MUGA or 2-dimensional echocardiogram


  • Not pregnant or nursing
  • Fertile patients must use effective contraception
  • No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or incidental carcinoid cancer
  • No evidence of active or uncontrolled infection
  • No severe gastrointestinal symptoms (i.e., partial obstruction) and/or gastrointestinal bleeding or diarrhea
  • No greater than grade 1 preexisting sensory neuropathy


Biologic therapy

  • At least 28 days since prior biologic consolidation therapy
  • No concurrent immunotherapy


  • See Disease Characteristics
  • At least 28 days since prior non-platinum-containing consolidation chemotherapy
  • No prior pegylated doxorubicin HCl liposome
  • No prior cumulative anthracycline (e.g., doxorubicin, daunorubicin, epirubicin) dose in excess of 240 mg/m^2
  • No other concurrent chemotherapy

Endocrine therapy

  • No concurrent hormonal therapy


  • No prior abdominopelvic irradiation
  • No concurrent radiotherapy


  • See Disease Characteristics
  • At least 28 days since prior surgical debulking for disease progression or recurrence and recovered
  • No concurrent surgery


  • No other prior treatment during the 6-24 month progression-free and platinum-free interval except up to 12 courses of consolidation therapy
  • No other concurrent anticancer therapy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00043082

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Sponsors and Collaborators
Southwest Oncology Group
National Cancer Institute (NCI)
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Study Chair: David S. Alberts, MD University of Arizona
Publications of Results:
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Responsible Party: Southwest Oncology Group Identifier: NCT00043082    
Other Study ID Numbers: CDR0000256331
S0200 ( Other Identifier: SWOG )
U10CA032102 ( U.S. NIH Grant/Contract )
First Posted: January 27, 2003    Key Record Dates
Last Update Posted: October 26, 2015
Last Verified: October 2015
Keywords provided by Southwest Oncology Group:
peritoneal cavity cancer
recurrent ovarian epithelial cancer
stage III ovarian epithelial cancer
stage IV ovarian epithelial cancer
Additional relevant MeSH terms:
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Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Liposomal doxorubicin
Antineoplastic Agents
Antibiotics, Antineoplastic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action