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Brain Control of Blinking

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00030199
Recruitment Status : Completed
First Posted : February 8, 2002
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

This study will use transcranial magnetic stimulation (TMS) to study how the brain controls movement of muscles in the face-in particular, those involved in eye blinking. TMS is a procedure that activates areas of the brain with magnetic pulses that travel through the scalp and the skull.

Healthy normal volunteers 21 years of age and older may be eligible for this study. They must be free of any serious medical illness, have no neurological or psychiatric disorders or history of seizures, and must not be taking any medications that can affect nervous system function.

Participants will undergo TMS and the electrical activity in muscles activated by the stimulation will be recorded. For TMS, an insulated wire coil is placed on the patient's scalp, and a brief electrical current is passed through the coil. This creates a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain. If the coil is placed over a nerve that controls muscles, there may be a twitch in the muscles, sometimes large enough to move the face. In other cases, there may be a feeling of movement or tingling sensation in the face. Stimulation over the muscles on the side of the head may cause some discomfort there or twitching of the jaw. During the stimulation, subjects may be asked to tense certain muscles slightly or perform other simple actions.

Electrical activity of the muscles activated by the stimulation is recorded. This is done with both metal electrodes taped to the skin over the muscle and with fine needle electrodes inserted into the muscles around the eyes.

The study usually takes less than 3 hours, with frequent breaks. If more time is required, the study will be broken into more than one session.

Condition or disease

Detailed Description:
The purpose of this study is to investigate the cortical center for voluntary control of eyelid closure using transcranial magnetic stimulation (TMS). Conventionally the primary motor cortex (M1) has been thought to control upper facial movement . However, recent neuroanatomical and neuroimaging studies suggest that the upper facial muscles are mainly controlled by the mesial frontal region, not M1 . Recently, we performed a transcranial magnetic stimulation (TMS) study to investigate the cortical center for the upper facial muscles, especially those related to blinking, and observed possible cortical responses from the surface electrodes attached to the orbicularis oculi (OOC) muscles with the stimulation applied to the mesial frontal region. In this study, we are planning to use monopolar needle electrodes to confirm that these responses originate from the cortical stimulation.

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Study Type : Observational
Enrollment : 10 participants
Official Title: Cortical Control of Voluntary Blinking
Study Start Date : February 2002
Study Completion Date : February 2004

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes


Inclusion criteria of this study are normal adult volunteers who are greater than or equal to 21 years old.


Exclusion criteria are those who have either any medico-surgical, neurological and psychiatric illness, who have been taking any medication with potential influence on nervous system function;

who have a pacemaker;

an implanted medical pump;

a metal plate or a metal object in the skull or eye (for example, after brain surgery); or

who have a history of seizure disorder.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00030199

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United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Layout table for additonal information Identifier: NCT00030199    
Other Study ID Numbers: 020119
First Posted: February 8, 2002    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: February 2004
Keywords provided by National Institutes of Health Clinical Center (CC):
Transcranial Magnetic Stimuli
Needle Electrode
Facial Muscles
Blink Reflex
Motor Cortex
Transcranial Magnetic Stimulation
Healthy Volunteer
Normal Control