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Exposure, Dose, Body Burden and Health Effects of Lead

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00013819
Recruitment Status : Completed
First Posted : March 30, 2001
Last Update Posted : April 14, 2015
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure, and the blood forming system. A total of 803 lead workers and 135 persons without occupational lead exposure are being studied in South Korea. Lead in the body is being assessed by measurement of blood lead, chelatable lead (an estimate of lead in the tissues), and lead in bone. Subjects are tested three times each over three years. Several genetic factors are also being assessed for the role they play in the health effects of lead. These genes are known to differ among individuals. We are interested to know whether different forms of the same genes can modify the effect lead has on health.

Condition or disease
Lead Poisoning

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Study Type : Observational
Enrollment : 944 participants
Time Perspective: Prospective
Official Title: Exposure, Dose, Body Burden and Health Effects of Lead
Study Start Date : February 1997
Actual Primary Completion Date : February 2001
Actual Study Completion Date : February 2001

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Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 70 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Lead workers in South Korea in one of 26 specific lead-using facilities.

Population controls in South Korea.

Layout table for additonal information Identifier: NCT00013819    
Other Study ID Numbers: 7198-CP-001
First Posted: March 30, 2001    Key Record Dates
Last Update Posted: April 14, 2015
Last Verified: April 2015
Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
lead poisoning
central nervous system
peripheral nervous system
occupational health
genetic susceptibility
Additional relevant MeSH terms:
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Lead Poisoning
Chemically-Induced Disorders
Heavy Metal Poisoning