Multi-Ethnic Study of Atherosclerosis (MESA)
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|ClinicalTrials.gov Identifier: NCT00005487|
Recruitment Status : Unknown
Verified August 2019 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was: Active, not recruiting
First Posted : May 26, 2000
Last Update Posted : November 7, 2019
|Condition or disease|
|Atherosclerosis Cardiovascular Diseases Heart Diseases Coronary Artery Disease Coronary Disease Stroke Myocardial Infarction Heart Failure Diabetes Mellitus, Type 2 Hypertension Diabetes Mellitus|
MESA was derived from an NHLBI Task Force on Research in Epidemiology and Prevention in which investigation of subclinical disease and its progression to clinical disease was recommended as a major focus for future NHLBI population studies. This was followed by a Special Emphasis Panel on Longitudinal Cohort Studies in 1995, which strongly recommended studies based on subclinical disease measures, and the inclusion of underrepresented minorities in population-based research. A subsequent Special Emphasis Panel on Use of Cardiac EBCT and MRI in Epidemiologic Studies of Cardiovascular Disease in 1996 recommended inclusion of carotid and cardiac MRI and EBCT in elucidating the progression of subclinical to clinical disease and identifying subclinical disease characteristics most strongly associated with increased risk. Requests for Proposals were released in 1997 and awards were made in 1999.
Participants were examined at baseline for evidence of subclinical CVD using cardiac computed tomography (CT), cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement; established and putative laboratory risk markers; and socioeconomic, psychological, behavioral, and environmental characteristics. Selected baseline components were repeated and additional components such as spirometry, retinal photography, genotyping, cognitive function assessment and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function, were introduced over five subsequent examinations through 2018. Stored blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted for study of candidate genes, genome-wide scanning, expression, and other -omics investigations, and lymphocytes were cryopreserved for possible immortalization.
MESA is unique in its composition of four ethnic groups, having a cohort free of clinical CVD at baseline, and having multiple - and in some cases unique - subclinical CVD measures over time in the same individuals. Data collected from a large number and variety of MESA ancillary studies, including major ancillary studies on air pollution, chronic lung disease, genetics, and sleep, further contribute to its uniqueness. For a list of all phenotypic data documentation and protocols, refer to the MESA website: www.mesa-nhlbi.org. The MESA data are available to qualifying investigators directly from the study and also through dbGaP (http://www.ncbi.nlm.nih.gov/gap) and BioLINCC (https://biolincc.nhlbi.nih.gov). A variety of stored biospecimens are also available from the study, including DNA, serum, plasma, and urine.
|Study Type :||Observational|
|Actual Enrollment :||6418 participants|
|Official Title:||Multi-Ethnic Study of Atherosclerosis (MESA)|
|Study Start Date :||January 1999|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2019|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005487
|Principal Investigator:||Robyn McClelland||University of Washington|
|Principal Investigator:||Russell Tracy||University of Vermont (biospecimen repository)|
|Principal Investigator:||Steven Shea||Columbia University|
|Principal Investigator:||Wendy Post||Johns Hopkins University|
|Principal Investigator:||Norrina Allen||Northwestern University|
|Principal Investigator:||Karol Watson||University of California, Los Angeles|
|Principal Investigator:||James Pankow||University of Minnesota|
|Principal Investigator:||Gregory Burke||Wake Forest University|