Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Primary CNS Lymphoma
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|ClinicalTrials.gov Identifier: NCT00003061|
Recruitment Status : Completed
First Posted : April 14, 2004
Last Update Posted : July 2, 2012
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of methotrexate and cytarabine plus radiation therapy in treating patients who have primary CNS lymphoma.
|Condition or disease||Intervention/treatment||Phase|
|Lymphoma||Drug: cytarabine Drug: methotrexate Radiation: radiation therapy||Phase 2|
OBJECTIVES: I. Determine the efficacy of methotrexate and cytarabine chemotherapy in combination with whole-brain radiation therapy for patients with non-AIDS related primary central nervous system lymphoma. II. Assess the response rate and safety of this chemotherapy regimen.
OUTLINE: Patients receive the first course of chemotherapy as soon as possible after diagnosis and staging. Methotrexate (MTX) IV is administered over 40-60 minutes on days 1 and 15. Cytarabine (AraC) is administered intrathecally on days 1 and 15. The second course of chemotherapy begins on day 29 or after bone marrow recovery. Radiation therapy begins no later than 3 weeks after completing chemotherapy. Patients are followed until death.
PROJECTED ACCRUAL: A maximum of 50 patients will be accrued.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Official Title:||Evaluating the MBVP Chemotherapy Schedule Followed by Consolidating Radiotherapy in Non-AIDS Related Primary Central Nervous System Lymphoma (NAPCL)|
|Study Start Date :||July 1997|
|Actual Primary Completion Date :||March 2002|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00003061
|Leuven, Belgium, B-3000|
|Institut Gustave Roussy|
|Villejuif, France, F-94805|
|Atrium Medical Centre|
|Heerlen, Netherlands, 6419 PC|
|Academisch Ziekenhuis Maastricht|
|Maastricht, Netherlands, 6202 AZ|
|Rotterdam Cancer Institute|
|Rotterdam, Netherlands, 3075 EA|
|Dr. Bernard Verbeeten Instituut|
|Tilburg, Netherlands, 5042 SB|
|Academisch Ziekenhuis Utrecht|
|Utrecht, Netherlands, 3508 GA|
|Study Chair:||Philip Poortmans, MD, PhD||Dr. Bernard Verbeeten Instituut|