A Study of Ro 24-7429 in Patients With HIV-Related Kaposi's Sarcoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00002314
Recruitment Status : Completed
First Posted : August 31, 2001
Last Update Posted : June 24, 2005
Information provided by:
NIH AIDS Clinical Trials Information Service

Brief Summary:
To study the effects of Ro 24-7429 on tumor growth in patients with HIV-related Kaposi's sarcoma. To study the safety and tolerance, effects on HIV replication, and immunologic effects of Ro 24-7429 in this patient population. To explore relationships between exposure to Ro 24-7429 and its metabolites with its antitumor and antiviral activities and drug toxicity.

Condition or disease Intervention/treatment Phase
Sarcoma, Kaposi HIV Infections Drug: Ro 24-7429 Phase 2

Study Type : Interventional  (Clinical Trial)
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase II Study of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV-Related Kaposi's Sarcoma

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria

Patients must have:

  • HIV seropositivity.
  • Biopsy-proven mucocutaneous Kaposi's sarcoma with fewer than 50 skin lesions and measurable disease.
  • No active opportunistic infection. NOTE:
  • Patients with CD4 count >= 200 cells/mm3 must have no prior opportunistic infection, as well as no active opportunistic infection.
  • Life expectancy of at least 24 weeks.
  • Stable weight (+/- 2 kg) by 28 days prior to study entry.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

  • Other active malignancies (except basal cell carcinoma of the skin and in situ cervical cancer).
  • Known or suspected hypersensitivity to benzodiazepines.
  • Evidence of clinically significant cardiac, respiratory, hepatic, gastrointestinal, endocrine, hematologic, psychiatric, neurologic, dermatologic, or allergic disease as determined by the investigator.
  • Ongoing diarrhea (> two liquid stools per day).
  • Grade 2 or worse signs and symptoms of AIDS Dementia Complex.
  • Alteration of mental status that may interfere with study compliance.

Concurrent Medication:


  • AZT, ddI, or ddC.
  • Experimental antiretrovirals.
  • Biologic response modifiers or immunomodulating agents (e.g., interferon).
  • Colony stimulating factors (erythropoietin, GM-CSF, G-CSF).
  • Ganciclovir.
  • Foscarnet.
  • H-2 antagonists (cimetidine, ranitidine, famotidine, nizatidine).
  • Omeprazole.
  • Benzodiazepines.
  • Any other investigational compound.
  • Ongoing systemic treatment with corticosteroids (other than replacement therapy for adrenal insufficiency or short-term therapy of no more than 28 days for bronchial asthma).
  • Cytotoxic chemotherapy (systemic and local).
  • Drugs known to cause systemic toxicity, if avoidable (e.g., myelosuppressive, hepatotoxic, nephrotoxic, or neurotoxic drugs).
  • Paromomycin sulfate.
  • Chronic suppressive therapy for CMV and/or MAI.

Patients with the following prior condition are excluded:

History of serious adverse reactions to benzodiazepines.

Prior Medication:


  • Interferons or immune modulators within 4 weeks prior to study entry.
  • Prior systemic cytotoxic chemotherapy (patients with CD4 counts >= 200 cells/mm3 only).
  • Benzodiazepines within 14 days prior to study entry.
  • Intralesional chemotherapy for Kaposi's sarcoma within 2 weeks prior to study entry.
  • Therapy with antiretroviral drugs (including AZT, ddI, ddC, d4T) or investigational drugs within 14 days prior to study entry.

Localized radiotherapy. Radiotherapy (other than localized). Active drug or alcohol abuse.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00002314

United States, California
CARE Ctr / UCLA Med Ctr
Los Angeles, California, United States, 900951793
United States, Massachusetts
New England Deaconess Hosp
Boston, Massachusetts, United States, 02215
Sponsors and Collaborators
Hoffmann-La Roche Identifier: NCT00002314     History of Changes
Other Study ID Numbers: 128A
First Posted: August 31, 2001    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 1993

Keywords provided by NIH AIDS Clinical Trials Information Service:
Sarcoma, Kaposi
Acquired Immunodeficiency Syndrome
Antineoplastic Agents
Gene Products, tat

Additional relevant MeSH terms:
HIV Infections
Sarcoma, Kaposi
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Herpesviridae Infections
DNA Virus Infections
Neoplasms, Vascular Tissue