A Phase I Study of Recombinant CD4(rCD4) in Patients With AIDS and AIDS-Related Complex
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To determine the safety profile and maximum tolerated dose (MTD) of recombinant soluble human CD4 (rCD4) therapy in patients with AIDS or AIDS related complex (ARC). To obtain a preliminary indication of the antiviral effects of rCD4 in patients with AIDS and ARC. To measure steady state serum levels of rCD4 following continuous infusion therapy.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients must have:
Diagnosis of AIDS or AIDS related complex (ARC).
Failure to tolerate or respond to zidovudine (AZT) or decided to decline AZT therapy.
The ability to sign a written informed consent form prior to treatment.
A willingness to abstain from all other experimental therapy for HIV infection during the entire study period.
A life expectancy of at least 3 months.
Patients with the following conditions or symptoms are excluded: