MRI Evaluation of Chest Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00001961
Recruitment Status : Completed
First Posted : January 19, 2000
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

This study will assess the value of magnetic resonance imaging (MRI) in detecting heart attack and heart attack risk in patients who come to the hospital emergency room because of chest pain. It will also investigate whether MRI can help predict the coronary status of patients 4 to 6 weeks and 1 year after emergency room admission.

Patients who come to the emergency room of Suburban Hospital in Bethesda, MD, because of chest pain may be asked to enroll in this study if they have not been diagnosed as having a heart attack. Participating patients will undergo a MRI scan as soon as emergency room doctors determine they are in stable condition. For this procedure, the patient lies on a table that slides into the MRI scanner-a large tubular machine with a magnetic field. During the scan, a contrast material is injected into the vein. This material brightens the image of the heart so that the blood flow can be seen. The scan will show if there are areas of heart muscle that received insufficient blood flow. A second scan will be done within 72 hours to look for coronary artery blockage that may require treatment. Patients will be followed by telephone 4 to 8 weeks after the scans and again 1 year after the scans to ask about any significant medical problems that may have occurred during those time periods.

This study will provide information that may improve emergency treatment of patients with acute chest pain by clarifying which patients require immediate medical treatment, which should be admitted to the hospital for further evaluation, and which may safely be discharged from the hospital.

Condition or disease Intervention/treatment Phase
Chest Pain Coronary Disease Myocardial Infarction Procedure: MRI Phase 2

Detailed Description:
Coronary artery disease remains the leading cause of death in the United States and results in high diagnostic and therapeutic costs. The overall costs associated with the care of patients with cardiovascular disease is projected to be $286.5 billion. Although MRI is a relatively expensive technology, this methodology can provide all the noninvasive diagnostic testing necessary to evaluate and triage patients with coronary artery disease. This "one stop shop" has the potential to lower overall testing on this important patient population and better delineate which patients require intervention. Beyond reproducing the results of existing diagnostic tests, MRI has unique abilities to characterize myocardial tissue adding information in the assessment of these patients that is not attainable by currently available methodologies. This study will examine the hypothesis that MRI assessment of regional LV function, resting myocardial perfusion, and myocardial tissue characteristics can accurately detect a higher fraction of patients with acute myocardial infarction than is possible with the ECG performed in the emergency department.

Study Type : Interventional  (Clinical Trial)
Enrollment : 360 participants
Primary Purpose: Treatment
Official Title: MRI Evaluation of Chest Pain Compatible With Myocardial Ischemia
Study Start Date : December 1999
Study Completion Date : January 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


Ages above age 21 (children are excluded because myocardial infarction is so rare in this population that the pre-test probability is comparable to the patients with less than 30 minutes of symptoms. Both of these groups have too small a fraction of true positive events to benefit from testing with a sensitivity and specificity of approximately 0.85. If initial results are better, we will reexamine the suitability of these tests for low risk populations).

Capable of giving informed consent.

30 minutes of chest pain compatible with myocardial ischemia (chest pain score greater than 4).

Less than 270 pounds.


Medical exclusions:

Patient states she may be pregnant (confirmed by urine or blood testing).

Severe congestive heart failure (unable to lie flat in bed).

Subjects on a mechanical ventilator.

MRI exclusions:

Subjects with a cardiac pacemaker or implantable defibrillator.

Subjects with a cerebral aneurysm clip.

Subjects with a neural stimulator (e.g. TENS-Unit).

Subjects with any type of ear implant.

Subjects with metal in eye (e.g. from machining).

Subjects with implanted devices (e.g. insulin pump, drug infusion device).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00001961

United States, Maryland
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)

Publications: Identifier: NCT00001961     History of Changes
Other Study ID Numbers: 000025
First Posted: January 19, 2000    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: January 2005

Keywords provided by National Institutes of Health Clinical Center (CC):
Myocardial Infarction
Coronary Artery Disease
Stress Testing

Additional relevant MeSH terms:
Myocardial Infarction
Coronary Disease
Coronary Artery Disease
Chest Pain
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms