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The Connection Between Areas in the Brain of Blind Patients

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ClinicalTrials.gov Identifier: NCT00001926
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:
The purpose of this study is to test the belief that specific areas of the brain are connected differently in blind patients than patients with sight. In addition, the study will examine the different anatomical connections between brain areas of patients who became blind early in life versus patients who became blind later.

Condition or disease Intervention/treatment
Blindness Brain Mapping Healthy Drug: O15 Device: Cadwell rTMS

Detailed Description:
The purpose of this protocol is to test the hypothesis that the anatomical connectivity of occipital and somatosensory areas in early blind subjects differs from that in subjects who became blind later in life and from that in sighted volunteers.

Study Type : Observational
Estimated Enrollment : 45 participants
Official Title: Connectivity of Occipital and Somatosensory Cortical Areas in Blind Subjects
Study Start Date : April 1999
Estimated Study Completion Date : November 2003

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes


Subjects with late blindness.

Subjects with early blindness.

Sighted volunteers.

Age between 18 and 65 years.


Subjects with personal or family history of seizures or other neurological or demyelinating disorders.

Pregnant women tested after urine pregnancy test.

Subjects with metal in the cranium except mouth.

Subjects with intracardiac lines and implanted medication pumps.

Subjects with increased intracranial pressure as evaluated by clinical means.

Subjects with cardiac pacemakers.

Intake or neuroleptics.

Subjects with blindness secondary to degenerative CNS diseases.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001926

United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)

ClinicalTrials.gov Identifier: NCT00001926     History of Changes
Other Study ID Numbers: 990031
First Posted: November 4, 1999    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: November 2003

Keywords provided by National Institutes of Health Clinical Center (CC):
Magnetic Stimulation
Transcranial Magnetic Stimulation

Additional relevant MeSH terms:
Vision Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Eye Diseases
Signs and Symptoms