Brain Imaging in Elderly People and Individuals With Alzheimer's Disease
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|ClinicalTrials.gov Identifier: NCT00001917|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
The purpose of this study is to use brain imaging technology to study the effects of aging and Alzheimer's Disease (AD) on a specific type of brain receptor.
The brain is made up of cells called neurons. The neurons communicate with one another and secrete chemicals called neurotransmitters. The neurotransmitters bind to specific sites on other neurons called receptors. Acetylcholine (ACh) is a neurotransmitter that binds to ACh receptors. In both aging and AD, the number of neurons that secrete ACh decreases and the function of some ACh receptors changes. This study will use positron emission tomography (PET) scans of the brain to study the effects of age and AD on muscarinic type 2 [M2], a type of ACh receptor.
Participants in this study will be injected with a radioactive tracer (ligand [F-18] FP-TZTP) which binds to [M2] receptors. Participants will then undergo a PET scan in order for the density and function of [M2] receptors to be studied.
|Condition or disease||Intervention/treatment|
|Alzheimer's Disease Healthy||Drug: O15 Drug: [F-18] FP-TZTP|
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Official Title:||M2 Receptor Measurements in Aging and in Alzheimer's Disease|
|Study Start Date :||April 1999|
|Estimated Study Completion Date :||April 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001917
|United States, Maryland|
|National Institute of Mental Health (NIMH)|
|Bethesda, Maryland, United States, 20892|