Methods for Measuring Insulin Sensitivity
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|ClinicalTrials.gov Identifier: NCT00001625|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : July 2, 2017
Patients with high blood pressure, diabetes, and who are overweight are known to have defects in the way their body responds to insulin. The purpose of this study is to develop better methods for measuring the way body tissue responds to insulin and sugar (glucose).
Researchers are planning to study four groups of patients.
- Normal volunteers
- Patients who have mild to moderate high blood pressure
- Patients who are overweight
- Patients who have mild to moderate diabetes controlled with oral medication
In this study patients and volunteers will undergo two separate tests designed to determine how well insulin is working in the body. The first test is called a glucose clamp test. Patients will have two needles placed in the veins of their arms. One needle will be used to take blood samples, the other needle will be used to inject doses of sugar (glucose) and insulin.
The second test is called the frequently sample intravenous glucose tolerance test. In this test patients will have sugar (glucose) injected into their veins followed by a slow injected dose (infusion) of insulin. Researchers will periodically take blood samples during the test.
Patients participating in the study will not directly benefit from it. However, the information gained from this study may be useful for improving the diagnosis and therapy of diseases such as diabetes, obesity, and high blood pressure (hypertension).
|Condition or disease|
|Obesity Hypertension Diabetes-Mellitus, Non-Insulin Dependent|
|Study Type :||Observational|
|Enrollment :||480 participants|
|Official Title:||Methods for Assessing Insulin Sensitivity In Vivo|
|Study Start Date :||April 3, 1997|
|Study Completion Date :||April 11, 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001625
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|