Study of the Response of Human Small Blood Vessels
|ClinicalTrials.gov Identifier: NCT00001622|
Recruitment Status : Completed
First Posted : December 10, 2002
Last Update Posted : March 4, 2008
A layer of cells called the endothelium line the walls of blood vessels. These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel. One of the substances produced involved in the control of blood vessel function is nitric oxide. Nitric oxide (NO) plays a role in the relaxation of blood vessels.
Researchers have been interested in the function of the endothelium in patients with high blood pressure (essential hypertension) and patients with high cholesterol (hypercholesterolemia).
After conducting studies on the endothelium and nitric oxide, researchers have found that the endothelium is indeed functioning abnormally in patients with high blood pressure and high cholesterol. In addition, researchers have determined that the dysfunction is a result of abnormalities in the nitric oxide (NO) system.
In this study researchers plan to investigate the relationship between blood vessel responses in real-life settings versus laboratory settings in normal volunteers, patients with high blood pressure, and patients with high cholesterol.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Hypercholesterolemia Hypertension||Procedure: investigate the relationship between in vivo and in vitro vascular responses||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||87 participants|
|Official Title:||Study of the Relation Between In Vivo and In Vitro Response of Human Small Vessels|
|Study Start Date :||March 1997|
|Estimated Study Completion Date :||March 2001|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001622
|United States, Maryland|
|National Heart, Lung and Blood Institute (NHLBI)|
|Bethesda, Maryland, United States, 20892|