All patients will receive a psychiatric and physical examination by a qualified physician.
Patients will be from 18 to 90 years of age and must give informed consent.
Unipolar patients must be medication free to participate. Patients with bipolar disorder depression may be medication-free or on any combination (including monotherapy) of lithium, carbamazepine, and valproate. Inpatient monitoring will be provided when medically indicated.
Reasons for exclusion will be the presence of cardiac pacemakers, medication pumps, cochlear implants or metal objects in the head or eyes that could be dangerous if heated or moved by the magnetic pulses.
General contraindications to rTMS or a current diagnosis of alcohol or substance abuse.
Subjects having serious medical illnesses or meeting current psychoactive substance dependence will be excluded from entry.