Genetic Study of Schizophrenia
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|ClinicalTrials.gov Identifier: NCT00001486|
Recruitment Status : Recruiting
First Posted : November 4, 1999
Last Update Posted : July 1, 2020
|Condition or disease|
|Schizoaffective Disorder Schizophrenia|
Objective: Schizophrenia is a complex genetic disorder which likely involves many genes each producing a slight increase in risk. Finding weak-acting genes in complex genetic disorders has been challenging and will likely require a number of approaches and large clinical samples. Several strategies have emerged recently that appear to markedly improve the power of genetic studies for detecting such genes. These include using association (rather than linkage) and using intermediate phenotypes in addition to DMS-IV diagnosis.
Study Population: We propose to take advantage of these techniques by studying quantitative traits related to schizophrenia in patients, siblings, and controls.
Design: We will employ an association design, rather than linkage. Traits will include quantifiable neurobiological variables that have been implicated previously as possible phenotypes related to schizophrenia. These include tests of attention and cognition, and a variety of parameters using brain imaging and magnetoencephalography.
Outcome Measure: We will use several statistical methods to show that specific genetic polymorphisms affect these phenotypes, including case control and family based association studies.
|Study Type :||Observational|
|Estimated Enrollment :||6150 participants|
|Official Title:||A Neurobiological Investigation of Patients With Schizophrenia Spectrum Disorders and Their Siblings|
|Actual Study Start Date :||July 15, 1995|
Male and female adult healthy volunteers
Parents of Probands and siblings for the purposes of DNA collection
Adult Subjects with Schizophrenia Spectrum Disorders
Adult siblings of Probands
- Genetic Polymorphisms affect phenotypes [ Time Frame: At time of study participation ]genotyping analysis
- PANSS, AIMS, GAF [ Time Frame: At time of study participation ]PANSS, AIMS, GAF
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001486
|Contact: Joann G Berkson, R.N.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Karen F Berman, M.D.||National Institute of Mental Health (NIMH)|