Glucocorticoid Effects on Cellular Cytokine Release
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|ClinicalTrials.gov Identifier: NCT00001415|
Recruitment Status : Completed
First Posted : December 10, 2002
Last Update Posted : March 4, 2008
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
Cortisol is a hormone produced in the adrenal glands as a response to stimulation from the pituitary gland. Abnormal levels of cortisol have been seen in several diseases such as depression and multiple sclerosis.
Cytokines are factors produced by certain white blood cells. They act by changing the cells that produce them (autocrine effect), altering other cells close to them (paracrine), and effecting cells throughout the body (endocrine effect). Cytokines are important in controlling inflammation processes.
In this study researchers would like to determine if changes in levels of hormones in the blood are associated with changes in cytokine levels. In addition, researchers would like to learn more about how cytokines respond to hormones in certain diseases.
|Condition or disease|
|Depressive Disorder Fatigue Syndrome, Chronic Fibromyalgia Healthy Inflammation|
|Study Type :||Observational|
|Enrollment :||130 participants|
|Official Title:||Glucocorticoid Effects on Cellular Cytokine Release|
|Study Start Date :||May 1994|
|Study Completion Date :||July 2000|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001415
|United States, Maryland|
|National Institute of Mental Health (NIMH)|
|Bethesda, Maryland, United States, 20892|