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Mapping Personality Traits to Genes

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00001414
First Posted: November 4, 1999
Last Update Posted: March 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

Previous research involving families, twins, and adoption all support the idea that there is a substantial heritable aspect to personality.

The goal of this research study is to determine how genetics influence heritable personality traits. The work will focus on how genetics affect the chemical messengers which brain cells use to communicate with each other (neurotransmitters).

The study involves collecting personality data and DNA samples from related individuals, primarily male siblings and female siblings, but also including parents. Genetic tests performed on these samples will continue to focus on variations in genes, which potentially effect brain neurotransmission.

This research has the potential to advance knowledge of genetic influences on human behavior that may be relevant both to normal personality and to psychopathology.


Condition
Mental Disorder

Study Type: Observational
Official Title: Mapping Personality Traits to Genes

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 2400
Study Start Date: April 1994
Estimated Study Completion Date: June 2002
Detailed Description:
Building on family, twin and adoption studies suggesting that substantial aspects of personality are heritable, research under this protocol explores potential genetic influences on normal personality dimensions. We have previously reported associations between variation in neurotransmitter system genes and variation in personality traits, both across and within families, in a sample of the general population. This study involves collecting personality data and DNA samples from related individuals, primarily male siblings and female siblings, but also including parents. Genetic tests performed on these samples will continue to focus on variations in genes, which potentially affect brain neurotransmission. In some cases, participants are recontacted to specifically investigate whether identified variations in neurotransmitter system genes actually affect neurotransmission. Large population samples are needed in this research, particularly since a new epidemiologically standard population sample will be obtained. This research has the potential to advance knowledge of genetic influences on human behavior that may be relevant both to normal personality and to psychopathology.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
Personality data and DNA samples will be collected from related individuals, primarily pairs of male and pairs of female siblings, but also including parents.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001414


Locations
United States, Maryland
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001414     History of Changes
Other Study ID Numbers: 940122
94-M-0122
First Submitted: November 3, 1999
First Posted: November 4, 1999
Last Update Posted: March 4, 2008
Last Verified: June 2002

Keywords provided by National Institutes of Health Clinical Center (CC):
Behavior Genetics
Normal Personality
Intelligence
Siblings
Sixteen Personality Factor Questionnaire
NEO-Personality Inventory (Revised)
X-Chromosome

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Schizophrenia Spectrum and Other Psychotic Disorders