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PET Scan to Map the Areas of the Brain Involved in Planning

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00001363
First Posted: December 10, 2002
Last Update Posted: March 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.

When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow.

This study will attempt to determine the areas of the brain activated by planning processes and decision making. Researchers will ask patients to participate in tests and games (chess) that will stimulate the areas of the brain involved with decision making and planning while undergoing the water PET blood flow technique.


Condition
Cognition Disorders

Study Type: Observational
Official Title: Functional Brain Mapping of Planning Activities With [015] Water PET Blood Flow Technique

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 230
Study Start Date: January 1993
Estimated Study Completion Date: March 2001
Detailed Description:
This protocol will attempt to determine the topographical distribution in the brain of the cognitive components of planning using the [150] water PET blood flow technique. We will administer perception, motor, simple decision, and planning tasks using the game of chess and the Tower of Hanoi Test as paradigms. Utilizing a "subtraction technique" we hope to identify those areas of cerebral cortex which are most activated by planning processes. It is predicted that the dorsolateral frontal areas will be most prominently activated. It is also predicted that the essential components of the planning process will be the same regardless of the type of plans being executed. The data we collect will be of value in determining 1) the neural representation of planning processes and 2) in guiding cognitive models of the planning system.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Normal Controls:

Males and female subjects from two age ranges: 18-30 and 50-65 years of age.

Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication.

Patients:

Patients with outstanding problems in planning.

Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center.

Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder).

Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001363


Locations
United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001363     History of Changes
Other Study ID Numbers: 930077
93-N-0077
First Submitted: November 3, 1999
First Posted: December 10, 2002
Last Update Posted: March 4, 2008
Last Verified: May 2000

Keywords provided by National Institutes of Health Clinical Center (CC):
Blood Flow
Chess Play
Frontal Lobe
Neurobehavioral Deficits
Neuropsychology
Positron Emission Tomography
Prefrontal Cortex

Additional relevant MeSH terms:
Cognition Disorders
Neurocognitive Disorders
Mental Disorders