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Studies of Blood Flow to the Brain During Thought

This study is currently recruiting participants.
Verified September 22, 2017 by National Institutes of Health Clinical Center (CC)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00001360
First Posted: November 4, 1999
Last Update Posted: October 4, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.

This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.


Condition
Cognition Disorder Healthy

Study Type: Observational
Official Title: Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 4100
Study Start Date: July 2, 1993
Detailed Description:

Objective:

Our goal is to study the functional organization of the intact human brain by combining cognitive tasks and neuroimaging. Functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) will be used to measure brain activity in healthy human subjects engaged in performing cognitive tasks. These tasks will address specific questions concerning the neural systems that mediate perception, attention, memory, decision-making, emotion, plasticity and social interactions. fMRI and MEG, respectively, will be employed to investigate the spatial and temporal aspects of these neural systems.

Study Population:

Normal volunteer participants aged 18-65, who are in good general health will be recruited from the local community and studied under this minimal risk protocol.

Design:

Subjects will perform cognitive tasks in behavioral and/or neuroimaging sessions (fMRI or MEG).

Outcome Measures:

Behavior as performance on cognitive tasks, and brain activity (fMRI and MEG) will be combined to yield information about the neural correlates and processes underlying different aspects of human cognition including visual perception, memory, learning, emotion, social cognition, decision-making and attention.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.

EXCLUSION CRITERIA:

Subjects will be excluded if they:

  • are an NIMH employee or a relative
  • have evidence of, or a history of:
  • major medical, neurological or psychiatric illness
  • serious head injury
  • learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine

-are taking prescription drugs or supplements that may affect brain function-

-have serious vision or hearing problems

In addition to the above, additional exclusion criteria apply for all MRI studies:

  • Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.
  • All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral and MEG experiments.
  • Subjects unable to lie flat on their back for up to 2 hours may not be eligible to participate in MRI scans.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001360


Contacts
Contact: Jessica Jordan (301) 435-4931 jessica.jordan@nih.gov
Contact: Leslie G Ungerleider, Ph.D. (301) 435-4932 ungerlel@intra.nimh.nih.gov

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010    prpl@mail.cc.nih.gov   
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Leslie G Ungerleider, Ph.D. National Institute of Mental Health (NIMH)
  More Information

Additional Information:
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00001360     History of Changes
Other Study ID Numbers: 930170
93-M-0170
First Submitted: November 3, 1999
First Posted: November 4, 1999
Last Update Posted: October 4, 2017
Last Verified: September 22, 2017

Keywords provided by National Institutes of Health Clinical Center (CC):
Cognition
Vision
Cortex
Visual Processing
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Cognition Disorders
Neurocognitive Disorders
Mental Disorders