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Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00001176
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.

Previous studies conducted on patients with salt sensitive hypertension suggest that their portion of the nervous system responsible for maintaining normal blood pressure (autonomic nervous system) may respond differently to salt than patients with non-salt sensitive (NSS) hypertension.

This study is designed to examine the response of the nervous system to high doses of salt in patients with salt-sensitive hypertension and patients with non-salt sensitive hypertension.

Condition or disease
Hyperaldosteronism Hypertension

Detailed Description:
A subset of patients with idiopathic hypertension shows an increase in blood pressure of 10 percent or more in response to salt-loading and have been termed "salt-sensitive" (SS). Limited studies of adrenergic function in response to salt-loading suggest that the response of SS patients may differ from that of non-salt sensitive (NSS) patients. The present studies were designed to examine the response of the adrenergic and dopaminergic systems to salt-loading in SS and NSS patients with idiopathic hypertension.

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Study Type : Observational
Enrollment : 110 participants
Official Title: The Function of Dopaminergic and Noradrenergic Systems in Salt-Sensitive Hypertension: The Effects of Changes in Sodium Intake
Study Start Date : May 1981
Study Completion Date : December 2001

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy Sodium

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Eligibility criteria not identified in protocol.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00001176

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United States, Maryland
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Layout table for additonal information Identifier: NCT00001176    
Other Study ID Numbers: 810081
First Posted: November 4, 1999    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: December 2001
Keywords provided by National Institutes of Health Clinical Center (CC):
Adrenergic Nervous System
Dopaminergic Nervous System
Salt-Sensitive Hypertension
Primary Aldosteronism
Additional relevant MeSH terms:
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Vascular Diseases
Cardiovascular Diseases
Immune System Diseases
Adrenocortical Hyperfunction
Adrenal Gland Diseases
Endocrine System Diseases