Evaluation of Factors in Human Brain Tumors
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|ClinicalTrials.gov Identifier: NCT00001171|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
Presently, patients with primary malignant brain tumors have a life expectancy of 15 weeks following surgery unless they receive additional types of therapy (chemotherapy, radiotherapy, and/or immunotherapy). Patients that receive additional therapy can increase life expectancy to 50 weeks.
The statistics on the life expectancy and survival have increased efforts among researchers to develop new treatments for primary malignant brain tumors.
This research project involves the growth and study of human brain tumor cells outside the body in the laboratory as part of an attempt to better understand these tumors and to develop more effective treatments for them.
|Condition or disease|
|Brain Neoplasm Glioblastoma Glioma Pituitary Neoplasm|
This protocol involves the study of human brain tumor cells outside the body in the laboratory as part of an attempt to better understand these tumors and to develop more effective therapeutic measures.
Malignant primary brain tumor patients at present have a life expectancy of approximately 15 weeks following surgery unless other adjunctive measures are taken. With currently available adjunctive therapy the life expectancy reaches 50 weeks.
These survival data have spurred extensive efforts to develop new treatment modalities. Radiation, chemotherapy and immunotherapy have been mildly helpful adjuncts but their use has been largely on empirical grounds or on the basis of experimentation on animal tumor models often quite different in nature from human brain tumors.
Our group has sought to develop data upon which to devise new treatment strategies for patients with malignant brain tumors.
The foundation of our approach rests upon the use of in vitro studies of the cell biology of each patient's tumor.
It is our plan to utilize these tumors for in vitro investigation of the immunology, biology, biochemistry and molecular biology of brain tumors. Optimal conventional therapy will be given to the patients as we seek to learn more of how the scientific information obtained can be used to help them.
|Study Type :||Observational|
|Estimated Enrollment :||800 participants|
|Official Title:||Evaluation of Biological, Immunological and Therapeutic Parameters in Brain Tumor Patients|
|Study Start Date :||July 1979|
|Estimated Study Completion Date :||September 2005|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001171
|United States, Maryland|
|National Institute of Neurological Disorders and Stroke (NINDS)|
|Bethesda, Maryland, United States, 20892|