Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00001154|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : January 12, 2021
Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in the development of hardening of the arteries (atherosclerosis).
Patients participating in this study will receive injections of lipoproteins or apolipoproteins (the protein component of lipoproteins) that have been isolated and purified. These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient.
Patients participating in the study will be required to have blood samples taken, and provide urine samples throughout the course of the study. In addition, patient will be required to follow a specially formulated diet. Patients will be weighed throughout the course of the study.
|Condition or disease|
|Hypolipoproteinemia Hypercholesterolemia Dyslipidemia Hyperlipidemia|
|Study Type :||Observational|
|Actual Enrollment :||759 participants|
|Official Title:||Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients|
|Actual Study Start Date :||September 3, 1976|
Subjects with new and undefined dyslipidemia
- No outcome. This is a disease discover protocol. [ Time Frame: 5 years ]Dyslipidemia
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001154
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Robert D Shamburek, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|