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Blood Sampling for Neurochemical and Genetic Testing

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ClinicalTrials.gov Identifier: NCT00001147
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : March 4, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:

This study involves sampling blood from both normal volunteers and patients with diseases known or suspected to involve body chemicals called catecholamines. The blood will be used to establish normal values for plasma levels of catecholamines and related neurochemicals; to test for abnormal neurochemical patterns in patients; and to establish a "bank" of DNA from normal volunteers and from patients to be used in future studies about possible alterations of catecholamine-related genes.

Study participants will report to NIH after fasting overnight except for water or noncaloric, noncaffeinated beverages. They must not have taken Tylenol for at least 5 days. Blood will then be drawn. DNA will be extracted and stored in the freezer for future studies.


Condition or disease
Autonomic Nervous System Disease Healthy Hypertension Pheochromocytoma

Detailed Description:
This project is to allow blood sampling from normal volunteers and patients with dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic systems. The blood is used to establish normal values for plasma levels of catechols and related neurochemicals; test for abnormal neurochemical patterns in patients; and establish a "bank" of DNA samples from normal volunteers and from patients, to be used in future studies about mutations or polymorphisms of catecholamine-related genes.

Study Design

Study Type : Observational
Estimated Enrollment : 500 participants
Official Title: Blood Sampling for Neurochemical and Genetic Testing
Study Start Date : October 1999
Estimated Study Completion Date : March 2004


Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

INCLUSION CRITERIA:

The subjects are healthy normal volunteers or patients with dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic systems. Children of any age above 4 years may participate. In the case of minors, consent is obtained from an adult who is legally responsible for the subject.

EXCLUSION CRITERIA:

Subjects in whom anatomic or technical factors preclude insertion of an arm intravenous (i.v.) catheter are excluded. Normal volunteers taking any prescribed medication are excluded. Normal volunteers who smoke cigarettes or consume alcohol daily are excluded.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001147


Locations
United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001147     History of Changes
Other Study ID Numbers: 000008
00-N-0008
First Posted: November 4, 1999    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: March 2004

Keywords provided by National Institutes of Health Clinical Center (CC):
Dopamine
Metanephrine
Norepinephrine
Epinephrine
Catecholamines
Tyrosine Hydroxylase
Monoamine Oxidase
Phenosulfotransferase
Sympathetic Nervous System
Normetanephrine

Additional relevant MeSH terms:
Nervous System Diseases
Pheochromocytoma
Autonomic Nervous System Diseases
Primary Dysautonomias
Paraganglioma
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Nerve Tissue