T-Cell Depletion in Unrelated Donor Marrow Transplantation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000591
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : April 15, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To determine if a reduction in morbidity and mortality from acute and chronic graft versus host disease (GvHD) can be achieved through use of T-cell depletion techniques without a counterbalancing increase in relapse of leukemia in patients receiving an unrelated donor marrow transplant.

Condition or disease Intervention/treatment Phase
Bone Marrow Transplantation Graft vs Host Disease Immunologic Diseases Leukemia Myelodysplastic Syndromes Procedure: lymphocyte depletion Phase 3

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Primary Purpose: Treatment
Study Start Date : November 1993
Study Completion Date : February 2005

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 55 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000591

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Shelly Carter The EMMES Corporation
OverallOfficial: John Wagner University of Minnesota - Clinical and Translational Science Institute

Study Data/Documents: Individual Participant Data Set  This link exits the site
Identifier: TCD
NHLBI provides controlled access to IPD through BioLINCC. Access requires registration, evidence of local IRB approval or certification of exemption from IRB review, and completion of a data use agreement.

Howe C, Wagner J, Kerman N, et al. 1995. T-cell Depletion in Unrelated-donor Marrow Transplantation. Blood 391a (abstract). Identifier: NCT00000591     History of Changes
Other Study ID Numbers: 311
First Posted: October 28, 1999    Key Record Dates
Last Update Posted: April 15, 2016
Last Verified: November 2005

Additional relevant MeSH terms:
Myelodysplastic Syndromes
Graft vs Host Disease
Immune System Diseases
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions