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Mode Selection Trial in Sinus Node Dysfunction (MOST)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00000561
First Posted: October 28, 1999
Last Update Posted: February 23, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Mt. Sinai Medical Center, Miami
  Purpose
To determine if dual chamber rate-modulated pacing (DDDR) in patients with sick sinus syndrome is superior to single chamber pacing (VVIR) with respect to subsequent frequency of adverse clinical events such as stroke, quality of life and function, and cost effectiveness.

Condition Intervention Phase
Arrhythmia Cardiovascular Diseases Heart Diseases Sick Sinus Syndrome Vascular Diseases Cerebrovascular Accident Device: pacemaker, artificial Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Mt. Sinai Medical Center, Miami:

Study Start Date: June 1995
Estimated Study Completion Date: May 2002
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Men and women with sick sinus syndrome.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000561


Sponsors and Collaborators
Mt. Sinai Medical Center, Miami
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
OverallOfficial: Gervasio Lamas Icahn School of Medicine at Mount Sinai
OverallOfficial: Kerry Lee Duke University
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00000561     History of Changes
Other Study ID Numbers: 105
U01HL049804 ( U.S. NIH Grant/Contract )
First Submitted: October 27, 1999
First Posted: October 28, 1999
Last Update Posted: February 23, 2016
Last Verified: May 2005

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Vascular Diseases
Stroke
Sick Sinus Syndrome
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Block
Pathologic Processes