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Hypertension Prevention Trial (HPT) Feasibility Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000501
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : November 26, 2013
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To test the feasibility and the efficacy of nutritional interventions in the primary prevention of hypertension in individuals predisposed to the development of hypertension; specifically, to test the hypothesis that reduction of weight and/or decreased sodium intake in obese individuals, or decreased sodium intake with or without increased potassium intake (in men and women, regardless of weight) would prevent the elevation of blood pressure and the incidence of hypertension.

Condition or disease Intervention/treatment Phase
Cardiovascular Diseases Heart Diseases Hypertension Obesity Vascular Diseases Behavioral: diet, sodium-restricted Behavioral: diet, reducing Drug: potassium Phase 2

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Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Primary Purpose: Prevention
Study Start Date : September 1981
Actual Study Completion Date : August 1986

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Potassium

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 49 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Men and women, ages 25 to 49. Diastolic blood pressure between 78 and 89 mm Hg. Free of major disease. Not on a special diet or antihypertensive medication at entry. Some mild to moderately obese subjects.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000501

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
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OverallOfficial: Nemat Borhani University of California, Davis
OverallOfficial: Robert Jeffery University of Minnesota
OverallOfficial: Herbert Langford University of Mississippi Medical Center
OverallOfficial: Albert Oberman University of Alabama at Birmingham
OverallOfficial: Ronald Prineas University of Minnesota
Hypertension Prevention Trial Research Group: Hypertension Prevention Trial--First Year Dietary Changes. In Strasser T, Ganten D, (Eds.). Mild Hypertension: From Drug Trials to Practice, New York, Raven Press, 1987.
Tonascia J, Donithan M, Tonascia S, et al for the Hypertension Prevention Trial Research Group: Hypertension Prevention Trial: Estimation of 24-hour Sodium and Potassium Excretion from Overnight Urine Collections. Baltimore, Maryland, Department of Biostatistics, Johns Hopkins University, Technical Report 703, 1989.

Layout table for additonal information Identifier: NCT00000501    
Other Study ID Numbers: 20
R01HL026585-07 ( U.S. NIH Grant/Contract )
First Posted: October 28, 1999    Key Record Dates
Last Update Posted: November 26, 2013
Last Verified: April 2012
Additional relevant MeSH terms:
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Cardiovascular Diseases
Heart Diseases
Vascular Diseases