Control of Hypertension by Non-Pharmacologic Means
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|ClinicalTrials.gov Identifier: NCT00000498|
Recruitment Status : Completed
First Posted : October 28, 1999
Last Update Posted : July 26, 2016
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Diseases Heart Diseases Hypertension Vascular Diseases||Behavioral: diet, sodium-restricted Behavioral: diet, reducing Behavioral: alcohol restriction Drug: antihypertensive agents||Phase 3|
In the 1970s, many studies had been conducted to control blood pressure in individuals maintained at normotensive levels by the use of weight control and sodium restriction without the concomitant use of anti-hypertensives. The associations between weight, sodium and blood pressure had been well established, but data on the relationship of intervention to blood pressure control had been less so.
Patients were randomly assigned to one of three groups. The 95 patients in Group I were advised to control weight, reduce sodium intake, modify dietary and alcohol intake and were removed from pharmacologic treatment. The 44 patients in Group II were removed from pharmacologic treatment, with no other intervention. The 48 patients in Group III were continued on pharmacologic treatment, with no other intervention. The primary endpoint was the proportion in Groups I and II with diastolic blood pressure less than or equal to 90 mm Hg in the absence of antihypertensive drugs. Secondary endpoints were average diastolic and systolic pressures.
The study completion date listed in this record was obtained from the CRISP legacy data.
|Study Type :||Interventional (Clinical Trial)|
|Study Start Date :||April 1980|
|Actual Study Completion Date :||March 1983|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000498
|OverallOfficial:||Richard Grimm||MOUNT SINAI HOSPITAL|
|OverallOfficial:||Jeremiah Stamler||Northwestern University|