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Cholesterol Reduction in Seniors Program (CRISP)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00000477
First Posted: October 28, 1999
Last Update Posted: February 18, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
  Purpose
To conduct a pilot study to determine whether lowering elevated serum cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors reduced mortality due to the sequelae of atherosclerotic cardiovascular disease in older men and women.

Condition Intervention Phase
Atherosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Hypercholesterolemia Myocardial Ischemia Drug: lovastatin Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Prevention

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: July 1990
Study Completion Date: June 1992
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 100 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Men and women, ages 65 and older, with elevated low-density lipoprotein cholesterol levels between 159 and 221 mg/dl at entry.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000477


Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
OverallOfficial: William Applegate University of Tennessee
OverallOfficial: John Crouse Bowman Gray School of Medicine
OverallOfficial: Donald Hunninghake University of Minnesota - Clinical and Translational Science Institute
OverallOfficial: Robert Knopp University of Washington
OverallOfficial: John LaRosa George Washington University
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00000477     History of Changes
Other Study ID Numbers: 66
U01HL044315 ( U.S. NIH Grant/Contract )
First Submitted: October 27, 1999
First Posted: October 28, 1999
Last Update Posted: February 18, 2016
Last Verified: June 1992

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Ischemia
Atherosclerosis
Hypercholesterolemia
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Pathologic Processes
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Lovastatin
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors