Calcium and Bone Mass in Young Females
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|ClinicalTrials.gov Identifier: NCT00000402|
Recruitment Status : Completed
First Posted : November 4, 1999
Last Update Posted : May 22, 2013
We originally suggested that calcium in the diet is important in determining the amount of bone (bone mass) that builds up in young adults. We are testing the effect of calcium on bone mass in 354 Caucasian (white) girls. At the start of this 7-year study, the average age of the girls was 11 years, and they had not yet reached puberty. The study will also provide information about the effect of calcium on body composition (body fat) and blood pressure in young women.
We have been giving calcium to one group of participants in this study and giving a placebo (an inactive pill, or "sugar pill") to the other group. The results of this research will be important in preventing osteoporosis, because building more bone as a young person should reduce a woman's chances of developing osteoporosis later in life.
|Condition or disease||Intervention/treatment||Phase|
|Osteoporosis||Drug: Calcium||Phase 2|
This study evaluates the effect of calcium on bone mass accretion over 7 years in a cohort of 354 young females who were in pubertal Stage II at the start of the study. The average age of study participants at entry was 11 years; at the end of the study participants were 18 years old.
The study looks at skeletal development under the influence of heredity, nutrition (calcium), and physical exercise. We gave calcium to participants in one arm of this clinical trial calcium. Participants in the other arm of the trial were given a placebo. The main outcome variable is the bone mass measured at different skeletal regions.
The study will also provide data about the efficacy of calcium supplementation with regard to hypertension prevention and obesity. The results of this research will be important in preventing osteoporosis.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||354 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Long Term Effects of Calcium on Bone Mass in Young Females|
|Study Start Date :||August 1991|
|Estimated Study Completion Date :||December 2001|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000402
|United States, Ohio|
|OSU Bone and Mineral Metabolism Laboratory|
|Columbus, Ohio, United States, 43210|
|Principal Investigator:||Velimir Matkovic, MD, PhD||Ohio State University|