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Treatments for Benign Paroxysmal Positional Vertigo (BPPV)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00000359
First Posted: November 3, 1999
Last Update Posted: July 26, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Helen Cohen, Baylor College of Medicine
  Purpose
The purpose of this study was to determine the relative short- and long-term efficacy of several physical treatment paradigms commonly employed for the treatment of benign paroxysmal positional vertigo (BPPV), including the canalith repositioning (Epley) maneuver, the liberatory (Semont) maneuver, the Brandt-Daroff exercises and nonspecific vestibular habituation exercises. These procedures involve exercises and head manipulations. Vertigo intensity and frequency, the presence/absence of slow-phase eye movements, the degree of dizziness handicap and acts of daily living (ADL) were assessed. The study also ascertained the effects of co-morbid conditions on the response to treatment. While BPPV is a common and significant public health problem that has been recognized for several decades, this is the first systematic study of the relative treatment efficacy of different physical treatment modalities for this disorder.

Condition Intervention Phase
Vertigo Behavioral: Canalith repositioning maneuver (Epley maneuver) Behavioral: Semont maneuver Behavioral: Brandt-Daroff exercises Behavioral: Vestibular habituation exercises Behavioral: ShamManeuver Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Treatments for Benign Paroxysmal Positional Vertigo (BPPV)

Resource links provided by NLM:


Further study details as provided by Helen Cohen, Baylor College of Medicine:

Primary Outcome Measures:
  • Vertigo [ Time Frame: 6 month s ]

Secondary Outcome Measures:
  • Balance [ Time Frame: 6 months ]

Enrollment: 150
Study Start Date: October 1998
Study Completion Date: June 2003
Primary Completion Date: June 2003 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Canalith repositioning maneuver
Repositioning treatment for posterior canal BPPV
Behavioral: Canalith repositioning maneuver (Epley maneuver)
Standard passive motion of the head: Dix-Hallpike maneuver, turn head to opposite side, roll over, sit up.
Other Names:
  • CRP
  • Epley maneuver
Experimental: Modified Epley maneuver Behavioral: Vestibular habituation exercises
Head shaking exercises in pitch, roll, yaw and circumduction. Titrating from 2 repetitions per exercise to 20 repetitions per exercise, as tolerated.
Sham Comparator: Sham
The subject sat in a chair; the head was passively tilted downward, turned away from the involved side, turned back to center, upward, away from the involved side, twice, slowly.
Behavioral: ShamManeuver
Passive movement of the head
Active Comparator: Liberatory maneuver
The standard liberatory maneuver (also known as the Semont maneuver) was used.
Behavioral: Semont maneuver
Sidelying maneuver, flip over 180 deg, sit up.
Other Name: Liberatory maneuver
Active Comparator: Brandt Daroff exercise
Modified Brandt Daroff exercise performed as a self-liberatory exercise.
Behavioral: Brandt-Daroff exercises
Active exercise. Sidelying to involved side, sidelying to uninvolved side, sit up.

  Eligibility

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Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients may be eligible for this study if they:

  • Are at least 21 years old.
  • Have a diagnosis of unilateral posterior semicircular canal BPPV according to established clinical test criteria.
  • Have functional to normal range of motion of the neck and the back.

Exclusion Criteria:

Patients will not be eligible for this study if they:

  • Have a history of prior ear surgery or prior treatment for BPPV.
  • Have an orthopedic or connective tissue disorder that impairs functional neck or trunk range of motion.
  • Have a significant neurological disorder or spinal cord damage.
  • Are on vestibular suppressant medications.
  • Have Meniere's disease or acoustic neuromas.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000359


Locations
United States, Texas
Baylor College of Medicine
Houston, Texas, United States, 77030
Sponsors and Collaborators
Baylor College of Medicine
National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Principal Investigator: Helen Cohen, EdD Baylor College of Medicine
  More Information

Publications:
Responsible Party: Helen Cohen, Professor, Baylor College of Medicine
ClinicalTrials.gov Identifier: NCT00000359     History of Changes
Other Study ID Numbers: NIDCD-1156
R01DC003602 ( U.S. NIH Grant/Contract )
1R01DC003602-01A1 ( U.S. NIH Grant/Contract )
First Submitted: November 2, 1999
First Posted: November 3, 1999
Last Update Posted: July 26, 2012
Last Verified: July 2012

Keywords provided by Helen Cohen, Baylor College of Medicine:
Physical Therapy
Vertigo
rehabilitation
occupational therapy

Additional relevant MeSH terms:
Vertigo
Dizziness
Benign Paroxysmal Positional Vertigo
Vestibular Diseases
Labyrinth Diseases
Ear Diseases
Otorhinolaryngologic Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Sensation Disorders