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Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2

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ClinicalTrials.gov Identifier: NCT00000310
Recruitment Status : Terminated
First Posted : September 21, 1999
Last Update Posted : January 16, 2017
Sponsor:
Collaborator:
VA Boston Healthcare System
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.

Condition or disease Intervention/treatment Phase
Cocaine-Related Disorders Drug: Risperidone Phase 2

Detailed Description:
Risperidone in low doses is compared with placebo in a 6-week randomized trial. Subjects also receive supportive counseling. Outcome measure include rating of behavior, mood, drug abuse, global function, and urine toxicology.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 0 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Official Title: Serotonin/Dopamine Antagonism of Cocaine Effect
Study Start Date : January 1996
Primary Completion Date : March 1996
Study Completion Date : March 1996

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Urine toxicology for cocaine
  2. Analog mood scales
  3. POMS
  4. EPS sx


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Cocaine abuse or dependence

Exclusion Criteria:

Dependence on other drugs. Major psychiatric illness


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000310


Locations
United States, Rhode Island
Brown University School of Medicine
Providence, Rhode Island, United States, 2906
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
VA Boston Healthcare System
Investigators
Principal Investigator: Lawrence Price, M.D. Brown University

ClinicalTrials.gov Identifier: NCT00000310     History of Changes
Other Study ID Numbers: NIDA-09330-2
R01-09330-2
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: January 16, 2017
Last Verified: January 1996

Keywords provided by National Institute on Drug Abuse (NIDA):
cocaine dependence

Additional relevant MeSH terms:
Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Risperidone
Cocaine
Dopamine
Serotonin
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Dopamine Antagonists
Dopamine Agents
Anesthetics, Local
Anesthetics
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Cardiotonic Agents
Sympathomimetics
Autonomic Agents