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Dextroamphetamine-Cocaine Behavioral Intervention - 5

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ClinicalTrials.gov Identifier: NCT00000308
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : January 12, 2017
Sponsor:
Collaborator:
University of Texas
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to examine dextroamphetamine-cocaine behavioral intervention in cocaine dependent patients.

Condition or disease Intervention/treatment Phase
Cocaine-Related Disorders Drug: Dextroamphetamine Drug: D-amphetamine Drug: placebo Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 54 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: D-amphetamine-Cocaine Behavioral Intervention
Study Start Date : September 1995
Actual Primary Completion Date : September 2000
Actual Study Completion Date : September 2000


Arm Intervention/treatment
Experimental: 1
15 mg of d-amphetamine for first 8 weeks of study and 30 mg for the second 8 weeks
Drug: Dextroamphetamine
15 mg of d-amphetamine for first 8 weeks of study and 30 mg for the second 8 weeks

Experimental: 2
30 mg of d-amphetamine for first 8 weeks of study and 60 mg for the second 8 weeks
Drug: D-amphetamine
15 mg of d-amphetamine for first 8 weeks of study and 30 mg for the second 8 weeks

Experimental: 3
placebo
Drug: placebo
placebo




Primary Outcome Measures :
  1. Verifiable cocaine abstinence [ Time Frame: 16 weeks of study ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Please contact site for information.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00000308


Locations
United States, Texas
University of Texas Health Science Center
Houston, Texas, United States, 77225
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
University of Texas
Investigators
Principal Investigator: John Grabowski, Ph.D. University of Texas

Responsible Party: F. Gerard Moeller, M.D., University of Texas Medical School at Houston
ClinicalTrials.gov Identifier: NCT00000308     History of Changes
Other Study ID Numbers: NIDA-09262-5
P50-09262-5
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: January 12, 2017
Last Verified: October 2016

Keywords provided by National Institute on Drug Abuse (NIDA):
cocaine dependence

Additional relevant MeSH terms:
Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Cocaine
Amphetamine
Dextroamphetamine
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
Central Nervous System Stimulants
Sympathomimetics
Autonomic Agents
Adrenergic Agents
Adrenergic Uptake Inhibitors