Buprenorphine Dose Alteration Study - 1

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000219
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : May 6, 2016
National Institute on Drug Abuse (NIDA)
Information provided by:
University of Vermont

Brief Summary:
The purpose of this study is to examine the effects in buprenorphine dose alterations in opioid dependent individuals being maintained on buprenorphine.

Condition or disease Intervention/treatment Phase
Opioid-Related Disorders Drug: Buprenorphine Phase 1

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 0 participants
Masking: Double
Primary Purpose: Treatment
Official Title: Buprenorphine Dose Alteration Study
Study Start Date : December 1991
Estimated Study Completion Date : July 2001

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Primary Outcome Measures :
  1. Opioid withdrawal
  2. Subjective dose estimate
  3. Drug effect characteristics: ARCI
  4. Physiological changes in: pupil diameter
  5. Physiological changes in: blood pressure
  6. Physiological changes in: heart rate
  7. Physiological changes in: respiration
  8. Physiological changes in: skin temperature

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 41 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000219

United States, Vermont
Treatment Research Center
Burlington, Vermont, United States, 05401
Sponsors and Collaborators
University of Vermont
National Institute on Drug Abuse (NIDA)
Principal Investigator: Warren Bickel, Ph.D. University of Vermont

In preparation. In preparation. Identifier: NCT00000219     History of Changes
Other Study ID Numbers: NIDA-06969-1
R18DA006969 ( U.S. NIH Grant/Contract )
First Posted: September 21, 1999    Key Record Dates
Last Update Posted: May 6, 2016
Last Verified: April 1992

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists