Multicenter Trial of Prednisone in Alzheimer's Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00000178
Recruitment Status : Completed
First Posted : November 1, 1999
Last Update Posted : June 24, 2005
Information provided by:
National Institute on Aging (NIA)

Brief Summary:
This is a randomized placebo controlled, double blind study. Patients who meet eligibility criteria and decide to participate in the study will be randomly assigned to receive either drug treatment or a placebo. Neither the patients nor the participating investigators will know who is receiving the drugs and who is receiving the placebo. Participation involves 15 outpatient clinic visits over a 68 week period. Patients take study medication at varying doses (the maximum dose is 20 mg daily), along with calcium and vitamin supplements.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Drug: Prednisone Phase 3

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Official Title: Multicenter Trial of Prednisone in Alzheimer's Disease

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with Alzheimer's disease who are in stable medical condition

Exclusion Criteria:

  • Patients with diabetes or severe osteoporosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00000178

United States, Alabama
University of Alabama, Birmingham
Birmingham, Alabama, United States, 35294-0017
United States, California
University of Southern California
Los Angeles, California, United States, 90033
University of California, San Diego
San Diego, California, United States, 92093-0949
United States, Florida
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32225
University of Miami
Miami, Florida, United States, 33140
University of South Florida
Tampa, Florida, United States, 33162
United States, Indiana
Indiana University Alzheimer's Center
Indianapolis, Indiana, United States, 46202
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21224
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110
United States, New York
New York University Medical Center
New York, New York, United States, 10016
Mount Sinai Medical Center
New York, New York, United States, 10029
Columbia Presbyterian Medical Center
New York, New York, United States, 11032
University of Rochester
Rochester, New York, United States, 14620
Burke Medical Research Institute
White Plains, New York, United States, 10605
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212-8646
United States, Texas
University of Texas
Dallas, Texas, United States, 75235-9070
Sponsors and Collaborators
National Institute on Aging (NIA)
Principal Investigator: Leon Thal, MD. University of California, San Diego

Publications of Results: Identifier: NCT00000178     History of Changes
Other Study ID Numbers: IA0002
3U01AG010483-08S2 ( U.S. NIH Grant/Contract )
First Posted: November 1, 1999    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: February 2005

Keywords provided by National Institute on Aging (NIA):
Alzheimer's disease
Anti-inflammatory agents

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal
Antineoplastic Agents