| 1 |
NCT03773536 |
Completed |
Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar |
- Plasmodium Falciparum Malaria
|
- Drug: Artesunate-amodiaquine given with single low dose primaquine
|
Interventional
|
Phase 4 |
- Professor Anders Björkman
- Ministry of Health and Social Welfare, Zanzibar
- Zanzibar Malaria Elimination Programme
- (and 2 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- PCR corrected cure rates for assessing efficacy of artesunate + amodiaquine given together with a single low dose primaquine in the treatment of uncomplicated Plasmodium falciparum infection
- Safety of artesunate + amodiaquine and primaquine: Incidence of adverse events
|
146 |
All |
3 Months and older (Child, Adult, Older Adult) |
NCT03773536 |
Aco V |
AcoV |
May 9, 2017 |
September 25, 2017 |
September 25, 2017 |
December 12, 2018 |
December 12, 2018 |
|
- Micheweni, Bububu Jesheni, and Uzini
Zanzibar, Tanzania
|
|
| 2 |
NCT03759821 |
Recruiting |
Engaging Fathers for Effective Child Nutrition and Development in Tanzania |
- Child Nutrition and Early Child Development
|
- Behavioral: Nutrition, mothers
- Behavioral: Nutrition, mothers and fathers
- Behavioral: Nutrition+parenting, mothers
- Behavioral: Nutrition+parenting, mothers and fathers
|
Interventional
|
Not Applicable |
- Project Concern International
- Purdue University
- Harvard School of Public Health
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Child dietary diversity (24 hrs)
- Early child development
- Child dietary diversity (7 days)
- (and 18 more...)
|
960 |
All |
up to 18 Months (Child) |
NCT03759821 |
01 |
EFFECTS |
October 30, 2018 |
January 31, 2021 |
January 31, 2021 |
November 30, 2018 |
December 17, 2018 |
|
- Project Concern International
Musoma, Mara, Tanzania
|
|
| 3 |
NCT03713502 |
Not yet recruiting |
Enteropathy and Diabetes in HIV Patients |
- Diabetes
- Environmental Enteropathy
- HIV
|
|
Observational
|
|
- National Institute for Medical Research, Tanzania
- University of Copenhagen
- London School of Hygiene and Tropical Medicine
- Queen Mary University of London
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Prevalence of diabetes
- Prevalence of pre-diabetes
|
1947 |
All |
18 Years and older (Adult, Older Adult) |
NCT03713502 |
TMA2017GSF-1965 |
REEHAD |
January 2019 |
December 2019 |
December 2022 |
October 19, 2018 |
December 19, 2018 |
|
- NIMR Research Clinic
Mwanza, Mwanza Region, Tanzania
|
|
| 4 |
NCT03709368 |
Enrolling by invitation |
Software Interventions for Improving Hand Washing and Sanitation in Rural Tanzania: an Impact Evaluation |
|
- Other: Hardware
- Behavioral: CLTS
- Behavioral: PHAST
- (and 3 more...)
|
Interventional
|
Not Applicable |
- Centre for Evidence-Based Practice, Belgium
- Tanzania Red Cross Society
- Muhimbili University of Health and Allied Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in hand washing behavior
- Change in latrine use behavior
- Quality of the hand washing infrastructure
- (and 3 more...)
|
1500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03709368 |
TAN-001 |
|
April 23, 2018 |
May 2021 |
May 2021 |
October 17, 2018 |
October 18, 2018 |
|
- Tanzania Red Cross Society
Kigoma, Tanzania
|
|
| 5 |
NCT03653975 |
Recruiting |
Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District |
- Nodding Syndrome
- Epilepsy
- Onchocerciasis
- Cognitive Impairment
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Describing clinical features in children with Nodding Syndrome and other forms of epilepsy e.g. characteristics of the seizures, EEG abnormalities and reporting co-morbidities and impairments.
- Describing EEG features in children with Nodding Syndrome and other forms
- Measuring the rate of filarial infections in patients with NS, epilepsy and controls.
- (and 4 more...)
|
250 |
All |
3 Years to 99 Years (Child, Adult, Older Adult) |
NCT03653975 |
HD-DZIF-MUHAS |
NSEC |
October 2014 |
May 2019 |
May 2019 |
August 31, 2018 |
August 31, 2018 |
|
- Mahenge Epilepsy Clinic
Mahenge, Tanzania
|
|
| 6 |
NCT03640403 |
Not yet recruiting |
Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania |
|
- Drug: Dihydroartemisinin-piperaquine
- Drug: Artesunate-amodiaquine
|
Interventional
|
Phase 3 |
- National Institute for Medical Research, Tanzania
- Universiteit Antwerpen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change from baseline in mean haemoglobin concentration at months 12 and 20 of follow-up
- Clinical malaria incidence from month 0 till months 12 and 20 of follow up
- Prevalence of asymptomatic malaria infections at month 0, 12 and 20 of follow up
- (and 8 more...)
|
1602 |
All |
5 Years to 15 Years (Child) |
NCT03640403 |
TEAM VERSION3 |
InSMART-school |
February 2019 |
December 2020 |
June 2021 |
August 21, 2018 |
February 5, 2019 |
|
- National Institute for Medical Research
Tanga, Tanzania
|
|
| 7 |
NCT03634696 |
Recruiting |
m-Palliative Care Link: Improving Palliative Care for Late Stage Tanzanian Cancer Patients |
|
- Other: mPCL
- Other: Usual Care
|
Interventional
|
Not Applicable |
- Susan Miesfeldt
- Maine Medical Center
- National Institutes of Health (NIH)
- (and 3 more...)
|
Other / NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Pain control
- Application utility
|
90 |
All |
21 Years and older (Adult, Older Adult) |
NCT03634696 |
1040841
R21TW010190 |
|
June 15, 2018 |
October 2019 |
January 1, 2020 |
August 16, 2018 |
August 16, 2018 |
|
- Ocean Road Cancer Institute
Dar Es Salaam, Tanzania
|
|
| 8 |
NCT03600142 |
Not yet recruiting |
A Stigma Reduction Intervention at Time of Entry Into Antenatal Care to Improve PMTCT Services in Tanzania |
|
|
Interventional
|
Not Applicable |
- Duke University
- Kilimanjaro Christian Medical Centre, Tanzania
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HIV care engagement (HIV-infected participants only)
- Internalized HIV stigma (HARSI) (HIV-infected participants only)
- Attitudes toward people living with HIV (HIV Stigma Scale) (HIV-uninfected participants only)
- (and 4 more...)
|
1000 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03600142 |
1R21TW011053-01 |
Maisha |
May 2019 |
April 2020 |
April 2020 |
July 25, 2018 |
August 2, 2018 |
|
- Kilimanjaro Christian Medical Centre
Moshi, Tanzania
|
|
| 9 |
NCT03597243 |
Recruiting |
Cash Transfer to Adolescent Girls and Young Women to Reduce Sexual Risk Behavior - an Impact Evaluation |
|
|
Interventional
|
Not Applicable |
- National Institute for Medical Research, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- HSV-2 Incidence
- HIV prevalence
- reporting of compensated sex
- reporting of intergenerational sexual partnerships
|
3120 |
Female |
15 Years to 23 Years (Child, Adult) |
NCT03597243 |
16.01.CT |
CARE |
October 30, 2017 |
July 15, 2019 |
December 15, 2019 |
July 24, 2018 |
July 25, 2018 |
|
- Shinyanga region
Kahama, Tanzania
|
|
| 10 |
NCT03596918 |
Recruiting |
Evaluating Quality of Life in Patients With AIDS-Associated Kaposi Sarcoma Treated With Bleomycin and Vincristine |
- AIDS-Related Kaposi Sarcoma
- Human Immunodeficiency Virus 1 Positive
|
- Biological: Bleomycin Sulfate
- Other: Laboratory Biomarker Analysis
- Other: Quality-of-Life Assessment
- (and 2 more...)
|
Interventional
|
Phase 1 |
- AIDS Malignancy Consortium
- National Cancer Institute (NCI)
- The EMMES Corporation
- (and 2 more...)
|
Other / NIH / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Quality of life assessed using Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT03596918 |
AMC-S007
NCI-2017-01864
UM1CA121947 |
|
October 10, 2018 |
March 31, 2020 |
March 31, 2020 |
July 24, 2018 |
October 12, 2018 |
|
- Bugando Medical Centre
Mwanza, Tanzania
|
|
| 11 |
NCT03594617 |
Recruiting |
Improving Care and Preventing Maltreatment of Orphans |
|
- Behavioral: Interaction Competencies with Children - for Caregiver
|
Interventional
|
Not Applicable |
- University of Konstanz
- Bielefeld University
- Dar es Salaam University College of Education
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in caregivers' application of harsh discipline
- Change in children's exposure to harsh discipline by caregivers
- Change in student's mental health
- Change in caregiver's attitudes towards harsh discipline
|
250 |
All |
6 Years to 80 Years (Child, Adult, Older Adult) |
NCT03594617 |
ICC-C-2018-Tanzania |
|
August 14, 2018 |
April 30, 2019 |
April 30, 2020 |
July 20, 2018 |
August 24, 2018 |
|
- Dar es Salaam University College of Education
Dar Es Salaam, Tanzania
|
|
| 12 |
NCT03559400 |
Recruiting |
RCT Intraoperative Gentamicin Versus No Antibiotics in Open Tibia Fractures |
|
- Drug: local gentamicin injection
- Procedure: debridement alone
|
Interventional
|
Not Applicable |
- University of California, San Francisco
- Muhimbili Orthopaedic Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Composite outcome of deep surgical site infection or fracture nonunion
- Euro-Qol 5 Dimensions (EQ-5D)
- Function index for trauma (FIX-IT) score
- (and 2 more...)
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03559400 |
17-23950 |
GO Tibia |
January 1, 2019 |
January 2022 |
January 2023 |
June 18, 2018 |
January 4, 2019 |
|
- Muhimbili Orthopaedic Institute
Dar Es Salaam, Tanzania
|
|
| 13 |
NCT03554616 |
Not yet recruiting |
Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets |
|
- Other: Chlorfenapyr LLIN
- Other: pyriproxyfen LLIN
- Other: Piperonyl butoxide LLIN
- Other: Standard LLIN
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- Kilimanjaro Christian Medical Centre, Tanzania
- National Institute for Medical Research, Tanzania
- University of Ottawa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Malaria infection prevalence in children 6 months to 14 years
- Incidence of malaria cases in children 6 months to 10 years
- Prevalence of anaemia in children under 5 years old
- (and 5 more...)
|
4200 |
All |
6 Months to 14 Years (Child) |
NCT03554616 |
ITDCZN11 |
|
December 1, 2018 |
July 31, 2021 |
October 31, 2021 |
June 13, 2018 |
September 18, 2018 |
|
- District Misungwi
Misungwi, Mwanza, Tanzania
|
|
| 14 |
NCT03501251 |
Completed |
Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura |
- Trichuris Trichiura; Infection
|
- Drug: Moxidectin 8mg
- Drug: Moxidectin 8 mg + albendazole 400 mg
- Drug: Moxidectin 16 mg
- (and 4 more...)
|
Interventional
|
Phase 2 |
- Swiss Tropical & Public Health Institute
- Public Health Laboratory Ivo de Carneri
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cure rate against Trichuris trichiura
- Egg Reduction Rate of the different drug regimens against Trichuris trichiura
- Cure rate of the different drug regimens against Ascaris lumbricoides
- (and 4 more...)
|
286 |
All |
16 Years to 18 Years (Child, Adult) |
NCT03501251 |
MOXI_DOSE_PEMBA |
MOXIDOSE |
July 3, 2018 |
August 11, 2018 |
August 11, 2018 |
April 17, 2018 |
August 14, 2018 |
|
- Public Health Laboratory Ivo de Carneri, P.O. Box 122
Chake Chake, Pemba, Tanzania
|
|
| 15 |
NCT03435874 |
Recruiting |
Safety and Immunogenicity of ChAd63 RH5 and MVA RH5 in Adults, Young Children and Infants Living in Tanzania |
|
- Biological: ChAd63 RH5
- Biological: MVA RH5
- Biological: Rabies Vaccine
|
Interventional
|
Phase 1 |
- University of Oxford
- Ifakara Health Institute
- Medical Research Council
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Solicited symptoms after vaccination.
- Unsolicited symptoms after each vaccination.
- Serious adverse events during the study period.
- (and 4 more...)
|
63 |
All |
6 Months to 35 Years (Child, Adult) |
NCT03435874 |
VAC070 |
|
April 12, 2018 |
August 7, 2019 |
August 7, 2020 |
February 16, 2018 |
July 6, 2018 |
|
- Ifakara Health Institute Clinical Trial Facility
Bagamoyo, Tanzania
|
|
| 16 |
NCT03431714 |
Completed |
Efficacy and Safety of ASAQ and PD for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania |
- Uncomplicated Falciparum Malaria
|
- Drug: Artesunate amodiaquine
|
Interventional
|
Phase 4 |
- National Institute for Medical Research, Tanzania
- Muhimbili University of Health and Allied Sciences
- World Health Organization
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Adequate clinical response
- PCR corrected responses
|
333 |
All |
6 Months to 10 Years (Child) |
NCT03431714 |
NIMR-Tanzania |
GF-TES-2017 |
July 14, 2017 |
December 8, 2017 |
December 8, 2017 |
February 13, 2018 |
February 13, 2018 |
|
- National Institute for Medical Research
Tanga, Tanzania
|
|
| 17 |
NCT03420053 |
Recruiting |
Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults |
- Malaria
- Malaria,Falciparum
|
- Biological: PfSPZ Vaccine
- Other: Normal Saline Placebo
- Biological: PfSPZ Challenge
|
Interventional
|
Phase 1 |
- Sanaria Inc.
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
- Medical Care Development, Inc.
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Safety of PfSPZ Vaccine - solicited symptoms
- Safety of PfSPZ Vaccine - unsolicited symptoms
- Safety of PfSPZ Vaccine - laboratory abnormalities
- (and 2 more...)
|
21 |
All |
18 Years to 45 Years (Adult) |
NCT03420053 |
BSPZV3a |
|
February 7, 2018 |
October 2018 |
October 30, 2018 |
February 2, 2018 |
October 16, 2018 |
|
- Bagamoyo Research and Training Center of the Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 18 |
NCT03334552 |
Recruiting |
Identification of Broadly HIV-1 Neutralizing Antibodies (bNAb) in HIV-infected Patients in Mbeya, Tanzania. |
|
|
Observational
|
|
- Michael Hoelscher
- National Institute for Medical Research - Mbeya Medical Research Centre (NIMR-MMRC)
- University Clinic of Cologne, Department of Internal Medicine, Center for Molecular Medicine Cologne (CMMC)
- (and 2 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Broadly HIV-1 neutralizing antibodies (bNAb)
- To characterize HIV subtypes in elite neutralizer and optionally in non-neutralizer
- To characterize demographic and HIV status related factors associated with elite neutralizers and non-neutralizers
- To optionally investigate the proportion of patients with transmitted drug mutations (genotypic drug resistance)
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03334552 |
LMU-IMPH-bNAb |
bNAb |
October 15, 2017 |
December 30, 2018 |
January 31, 2019 |
November 7, 2017 |
July 20, 2018 |
|
- NIMR-Mbeya Medical Research Center (MMRC)
Mbeya, Tanzania
|
|
| 19 |
NCT03311698 |
Active, not recruiting |
Homestead Agriculture and Nutrition Project |
- Diet Modification
- Health Behavior
|
- Behavioral: Nutrition-sensitive intervention
|
Interventional
|
Not Applicable |
- Harvard School of Public Health
- Ifakara Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Dietary diversity defined as number of food groups consumed out of 10
- Child height/length
- Child weight
- (and 11 more...)
|
1007 |
Female |
18 Years to 45 Years (Adult) |
NCT03311698 |
HSPH-16-0397 |
HANU |
July 20, 2016 |
December 31, 2019 |
December 31, 2019 |
October 17, 2017 |
December 11, 2018 |
|
- Ifakara Health Institute
Dar es Salaam, Mikocheni, Tanzania
|
|
| 20 |
NCT03268902 |
Active, not recruiting |
Early Life Interventions for Childhood Growth and Development In Tanzania |
- Malnutrition
- Stunting
- Cognitive Development
- Enteric Pathogens
|
- Drug: Azithromycin Oral Liquid Product
- Drug: Nitazoxanide Oral Suspension
- Dietary Supplement: Nicotinamide
- Drug: Placebos
|
Interventional
|
Phase 2
Phase 3 |
- Haydom Lutheran Hospital
- University of Virginia
- Bill and Melinda Gates Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Height-for-age z-score (HAZ) at 18 months
- Weight-for-age z-score (WAZ) at 18 months
- Head circumference-for-age z-score (HCAZ) at 18 months
- (and 16 more...)
|
1188 |
All |
up to 14 Days (Child) |
NCT03268902 |
19465 |
ELICIT |
September 5, 2017 |
September 2020 |
December 2020 |
August 31, 2017 |
October 15, 2018 |
|
- Haydom Lutheran Hospital
Haydom, Manyara, Tanzania
|
|
| 21 |
NCT03252288 |
Active, not recruiting |
mHealth-Assisted Conditional Cash Transfers to Improve Timeliness of Vaccinations |
|
- Behavioral: Reminders
- Behavioral: Conditional financial transfers
|
Interventional
|
Not Applicable |
- Duke University
- John E. Fogarty International Center (FIC)
- University of South Carolina
- National Institute for Medical Research, Tanzania
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Timely vaccination visits
- Number of vaccinations received
- Number of timely vaccinations received
|
412 |
Female |
16 Years and older (Child, Adult, Older Adult) |
NCT03252288 |
D0271
1R21TW010262 |
MINT |
August 15, 2017 |
December 31, 2018 |
December 31, 2018 |
August 17, 2017 |
December 20, 2018 |
|
- National Institute for Medical Research
Dar es Salaam, Tanzania
|
|
| 22 |
NCT03245398 |
Completed |
Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children |
|
- Drug: Treatment with one of the two regimens of mebendazole
|
Interventional
|
Phase 4 |
- Jennifer Keiser
- PATH
- Public Health Laboratory Ivo de Carneri
- Swiss Tropical & Public Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cure rate of mebendazole against hookworm
- Egg reduction rate (ERR) of the two regimens of mebendazole against hookworm
- CR of both mebendazole regimens against concomitant soil-transmitted helminth infections
- (and 2 more...)
|
186 |
All |
6 Years to 12 Years (Child) |
NCT03245398 |
TRIPLEMEB_PEMBA |
|
July 25, 2017 |
September 15, 2017 |
September 15, 2017 |
August 10, 2017 |
March 2, 2018 |
|
- Public Health Laboratory Ivo de Carneri, P.O. Box 122
Chake Chake, Pemba, Tanzania
|
|
| 23 |
NCT03133832 |
Recruiting |
The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium |
- Schistosomiasis Haematobia
|
|
Interventional
|
Phase 3 |
- Jiangsu Institute of Parasitic Diseases
- World Health Organization
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The cure rate of the two treatment
- The egg reduction of the two treatment
|
120 |
All |
7 Years to 60 Years (Child, Adult) |
NCT03133832 |
JIPD2017001 |
|
April 10, 2017 |
June 30, 2017 |
July 10, 2017 |
April 28, 2017 |
April 28, 2017 |
|
- NTD office, Pemba,Ministry of Health, Zanzibar
Pemba, Zanzibar, Tanzania
|
|
| 24 |
NCT03106480 |
Recruiting |
Diabetes Mellitus and HIV Study in Mwanza |
- Diabetes Mellitus
- HIV/AIDS
|
|
Observational
|
|
- National Institute for Medical Research, Tanzania
- University of Copenhagen
- Rigshospitalet, Denmark
- (and 5 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Combined prevalence of pre-diabetes and diabetes
- Prevalence of hypertension
- Combined incidence of pre-diabetes and diabetes
- (and 6 more...)
|
1900 |
All |
18 Years and older (Adult, Older Adult) |
NCT03106480 |
16-P01-TAN |
CICADA |
October 6, 2016 |
October 2019 |
March 2021 |
April 10, 2017 |
April 10, 2017 |
|
- NIMR Research Clinic
Mwanza, Mwanza Region, Tanzania
|
|
| 25 |
NCT03098693 |
Recruiting |
Dyadic-Based Diagnosis, Care and Prevention for HIV Discordant Couples in Tanzania |
|
- Behavioral: HIV Self-Testing
- Behavioral: Immediate Access to ART for HIV infected couple members
- Behavioral: Access to PrEP for HIV uninfected couple members
|
Observational
|
|
- Medical University of South Carolina
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Utilization of HIV Self-Test Kits
- Sharing of HIV Test Results with Primary Partner
- Proportion of HIV Sero-discordant Couples who Engage in HIV Care Together
- (and 11 more...)
|
120 |
All |
18 Years to 55 Years (Adult) |
NCT03098693 |
R01MH106369-01
R01MH106369 |
DDCP |
November 21, 2017 |
December 2019 |
April 2020 |
April 4, 2017 |
March 29, 2018 |
|
- Muhimbili University of Health and Allied Programs
Dar Es Salaam, Pwani, Tanzania
|
|
| 26 |
NCT03098654 |
Recruiting |
Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care In Kisarawe, Tanzania |
- Human Immunodeficiency Virus
- Diabetes Mellitus, Type 2
- Hypertension
|
- Diagnostic Test: Blood glucose and blood pressure testing
- Behavioral: Diet and lifestyle counseling
- Drug: DM/HTN medications as needed
|
Interventional
|
Not Applicable |
- Medical University of South Carolina
- National Institute of Mental Health (NIMH)
- Muhimbili University of Health and Allied Sciences
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Uptake of community-level HIV testing
- Engagement in HIV care
- Retention in HIV care
- (and 5 more...)
|
178 |
All |
18 Years and older (Adult, Older Adult) |
NCT03098654 |
Pro00064733
1R01MH111366-01 |
|
February 5, 2018 |
June 30, 2021 |
June 30, 2021 |
April 4, 2017 |
February 26, 2018 |
|
- Muhimbili University of Health and Allied Sciences
Dar Es Salaam, Tanzania
|
|
| 27 |
NCT03024905 |
Recruiting |
Project to Use Community Health Workers to Reduce Maternal Deaths |
- Maternal Mortality
- Access to Health Care
|
- Behavioral: Village meeting and travel vouchers
- Device: Birth kit with misoprostol
|
Interventional
|
Not Applicable |
- Bruyere Research Institute
- Ottawa Hospital Research Institute
- Shirati KMT Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Facility births
- Antenatal Care visits
- Postpartum visits
- (and 2 more...)
|
17000 |
Female |
Child, Adult, Older Adult |
NCT03024905 |
108026 |
EWH |
January 16, 2017 |
February 2019 |
February 2019 |
January 19, 2017 |
July 24, 2017 |
|
- Shirati District Hospital Research Office
Shirati, Rorya District, Mara Region, Tanzania
|
|
| 28 |
NCT03023033 |
Completed |
Supporting Attendance for Facility Delivery and Infant Health |
|
- Behavioral: mHealth messaging
- Behavioral: Transport Payments
|
Interventional
|
Not Applicable |
- Elizabeth Glaser Pediatric AIDS Foundation
- Population Council
- Ministry of Health, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Attendance for Early infant diagnosis (EID) of HIV
- Early identification of HEI at Reproductive and Child Health (RCH) Clinic
- Antenatal care (ANC) visits
- (and 8 more...)
|
1505 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03023033 |
EGPAF0130 |
SAFI |
October 2014 |
March 2016 |
November 2016 |
January 18, 2017 |
January 18, 2017 |
|
- Elizabeth Glaser Pediatric AIDS Foundation
Dar es Salaam, Tanzania
|
|
| 29 |
NCT02971553 |
Recruiting |
PEEP Resuscitation Trial |
|
- Device: Upright Resuscitator with PEEP
- Device: Upright Resuscitator
|
Interventional
|
Not Applicable |
- Helse Stavanger HF
- Haydom Lutheran Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Delta heart rate (beats/minute) during each ventilation sequence
- Neonatal outcome dead versus alive
- Time to cessation of ventilation
- (and 3 more...)
|
330 |
All |
Child, Adult, Older Adult |
NCT02971553 |
Upright PEEP |
PEEPrest |
September 2016 |
April 2018 |
April 2018 |
November 23, 2016 |
May 19, 2017 |
|
- Haydom Lutheran Hospital, Research Institute
Haydom, Manyara, Tanzania
|
|
| 30 |
NCT02938975 |
Not yet recruiting |
Field Efficacy Of Insecticide Treated Uniforms And Skin Repellents for Malaria Prevention |
|
- Other: Ultra 30 Insect Repellent Lotion (30% Lipo DEET)
- Other: Permethrin Factory-Treated Army Combat Uniforms
- Other: Placebo lotion
- Other: Army combat uniform
|
Interventional
|
Phase 3 |
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
- Walter Reed Army Institute of Research (WRAIR)
- U.S. Army Medical Research and Materiel Command
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of Plasmodium falciparum malaria through monthly measurement of malaria positivity by direct polymerase chain reaction (PCR) to detect parasite DNA
- Incidence of clinical malaria through monthly measurement malaria positivity of SD Bioline Malaria Rapid Diagnostic Test to test for parasite antigen
- Compliance with intervention as measured through spot checking and weighing of repellent bottles
- Protective efficacy of uniforms measured by reduction in Anopheles arabiensis bites among those wearing uniforms for a sub-sample of uniforms tested under laboratory conditions with free flying mosquitoes
|
1500 |
All |
18 Years to 40 Years (Adult) |
NCT02938975 |
BIT014 PR001 V01 |
URCT |
November 2017 |
January 2019 |
June 2019 |
October 19, 2016 |
June 6, 2017 |
|
- Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 31 |
NCT02909712 |
Unknown † |
Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania |
- Malaria
- Pregnancy
- Cardiotoxicity
- Parasitemia
|
- Drug: sulfadoxine-pyrimethamine (SP)
- Drug: dihydroartemisinin-piperaquine (DHA-PQP)
|
Interventional
|
Phase 2 |
- London School of Hygiene and Tropical Medicine
- Kilimanjaro Christian Medical Centre, Tanzania
- National Institute for Medical Research, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Proportion of participants in Groups 3-4 with an absolute QTc of > 500 milliseconds
- Proportion of participants in Groups 1-2 with an absolute QTc of > 500 milliseconds
- Proportion of participants in Groups 1-2 with an absolute QTc of > 480 milliseconds
- (and 34 more...)
|
200 |
Female |
18 Years to 34 Years (Adult) |
NCT02909712 |
9751 |
|
September 2016 |
March 2017 |
September 2017 |
September 21, 2016 |
September 21, 2016 |
|
- Handeni District Hospital
Handeni, Tanga Region, Tanzania
|
|
| 32 |
NCT02888288 |
Active, not recruiting |
Integrating Mental Health Into a HIV Clinic to Improve Outcomes Among Tanzanian Youth |
- Health Behavior
- HIV
- Mental Health
|
- Behavioral: Mental Health Intervention
- Behavioral: Standard of Care
|
Interventional
|
Not Applicable |
- Duke University
- Kilimanjaro Christian Medical Centre, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Participant attendance
- Caregiver participation as measured by questionnaire
- Caregiver participation as measured by attendance sheet
- (and 9 more...)
|
130 |
All |
12 Years to 24 Years (Child, Adult) |
NCT02888288 |
Pro00069892 |
|
July 2016 |
August 2019 |
June 2020 |
September 5, 2016 |
November 21, 2018 |
|
- Kilimanjaro Christian Medical Centre
Moshi, Tanzania
|
|
| 33 |
NCT02862925 |
Completed |
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings. |
- Fetal Distress
- Stillbirth
- Birth Asphyxia
- Acidosis
|
- Procedure: Fetal Scalp Stimulation
|
Interventional
|
Not Applicable |
- Duke University
- John E. Fogarty International Center (FIC)
- Fulbright
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Feasibility as measured by completion of all 3 study objectives
- Predicted fetal acidosis from cord blood pH (at thresholds of cord blood pH<7.0, 7.1, and 7.2)
- Fetal distress rate
- Change in cesarean delivery rate
|
550 |
Female |
15 Years to 50 Years (Child, Adult) |
NCT02862925 |
Pro00070952
R25TW009337 |
|
October 1, 2016 |
June 30, 2017 |
June 30, 2017 |
August 11, 2016 |
September 5, 2017 |
|
- Kilimanjaro Christian Medical Center
Moshi, Kilimanjaro, Tanzania
|
|
| 34 |
NCT02834637 |
Active, not recruiting |
A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls |
|
- Drug: bivalent HPV vaccine
- Drug: nonavalent HPV vaccine
|
Interventional
|
Phase 3 |
- London School of Hygiene and Tropical Medicine
- University of York
- Catalan Institute of Oncology
- (and 5 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- non-inferiority of antibody seropositivity of 1 dose compared with 2 or 3 doses of the same vaccine
- non-inferiority of antibody geometric mean titre (GMT) of 1 dose of either vaccine compared with historical cohorts of women who received 1 dose in whom efficacy has been demonstrated
- non-inferiority of HPV 16/18 seropositivity after 1 dose compared with 2 or 3 doses of the same vaccine
- (and 14 more...)
|
930 |
Female |
9 Years to 14 Years (Child) |
NCT02834637 |
MITU-002 |
DoRIS |
February 23, 2017 |
November 2020 |
March 2021 |
July 15, 2016 |
March 7, 2018 |
|
- Mwanza Intervention Trials Unit (MITU)
Mwanza, Tanzania
|
|
| 35 |
NCT02828267 |
Recruiting |
Evaluating a Brief Negotiational Intervention for Alcohol Use Among Injury Patients in Tanzania |
|
- Behavioral: Brief Negotiational Intervention
|
Interventional
|
Not Applicable |
- Duke University
- Kilimanjaro Christian Medical Centre, Tanzania
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Recruitment Rates
- Retention Rates
- Change in retention rates
- Acceptability of participation in trial and intervention as measured by questionnaire
|
60 |
All |
18 Years to 110 Years (Adult, Older Adult) |
NCT02828267 |
Pro00062061
K01TW010000 |
BNI |
July 1, 2018 |
June 2019 |
June 2019 |
July 11, 2016 |
August 1, 2018 |
|
- Kilimanjaro Christian Medical Center
Moshi, Tanzania
|
|
| 36 |
NCT02790814 |
Completed |
Moyo; strap-on Fetal Heart Rate Monitoring in a Rural Setting |
|
- Device: Moyo strap-on
- Device: Hand-held fetoscope
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Frequency of abnormal fetal heart rate detection
- Mode of delivery: vaginal versus operative
- Neonatal outcome: dead versus alive
- Time from abnormal fetal heart rate detection to delivery in minutes
|
2652 |
All |
Child, Adult, Older Adult |
NCT02790814 |
Moyo Rural |
|
February 2016 |
March 2017 |
March 2017 |
June 6, 2016 |
May 23, 2017 |
|
- Haydom Lutheran Hospital, Research Institute
Haydom, Manyara, Tanzania
|
|
| 37 |
NCT02790554 |
Completed |
Moyo; strap-on Fetal Heart Rate Monitoring in an Urban Setting |
|
- Device: Moyo strap-on
- Device: Hand-held Doppler
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Frequency of abnormal fetal heart rate detection
- Mode of delivery: vaginal versus operative
- Time interval from abnormal fetal heart rate detection to delivery in minutes
- Neonatal outcome dead versus alive
|
2973 |
All |
Child, Adult, Older Adult |
NCT02790554 |
Moyo Urban |
|
March 2016 |
September 2017 |
September 2017 |
June 6, 2016 |
October 20, 2017 |
|
- Muhimbili National Hospital
Dar es Salaam, Tanzania
|
|
| 38 |
NCT02721186 |
Completed |
Effectiveness of Mass Drug Administration for Reducing Seasonal Malaria Transmission in Zanzibar |
- Malaria
- Plasmodium Infections
|
- Drug: MDA with DHAp and SLD Primaquine
|
Interventional
|
Not Applicable |
- Ulrika Morris
- Mahidol Oxford Tropical Medicine Research Unit
- RTI International
- (and 5 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Cumulative notified malaria incidence in the MDA and control Shehias
- PCR determined community prevalence of Plasmodium infections in the MDA and control Shehias
|
22500 |
All |
6 Months and older (Child, Adult, Older Adult) |
NCT02721186 |
MaDrAZ-001
ZAMREC/0001/January/2016 |
MaDrAZ |
April 30, 2016 |
December 31, 2016 |
September 30, 2017 |
March 29, 2016 |
October 5, 2017 |
|
- Zanzibar Malaria Elimination Programme
Mwanakwerekwe, Urban District, Zanzibar, Tanzania
|
|
| 39 |
NCT02712424 |
Active, not recruiting |
DAR-901 TB Booster Vaccine to Prevent TB in Adolescents |
|
- Biological: DAR-901
- Biological: Sterile saline placebo
|
Interventional
|
Phase 2 |
- Dartmouth-Hitchcock Medical Center
- Muhimbili University of Health and Allied Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- New infection with Mycobacterium tuberculosis
- Persistent new infection with M. tuberculosis
|
650 |
All |
13 Years to 15 Years (Child) |
NCT02712424 |
29001 |
DAR-PIA |
March 2016 |
November 2019 |
December 2019 |
March 18, 2016 |
February 15, 2019 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 40 |
NCT02711293 |
Completed |
The Impact of Home Delivery of Antiretroviral Therapy on Virological Suppression |
- HIV
- Community Health Workers
- Antiretroviral Therapy, Highly Active
|
- Other: ART home delivery
- Other: Enhanced nutrition counseling
|
Interventional
|
Not Applicable |
- Harvard School of Public Health
- Management and Development for Health
- International Initiative for Impact Evaluation
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- The proportion of participants in viral failure, comparing participants that received the intervention (ART home delivery if stable on ART or standard facility-based care if unstable) versus those that received the standard of care.
- The mean BMI of participants in clusters assigned to standard counseling by CHWs versus those in clusters assigned to standard plus enhanced nutrition counseling.
- Participants' healthcare expenditures
- (and 4 more...)
|
2172 |
All |
18 Years and older (Adult, Older Adult) |
NCT02711293 |
RIDIE-STUDY-ID-562a718b12fa0 |
|
March 2016 |
February 2018 |
February 2018 |
March 17, 2016 |
March 6, 2018 |
|
- Management and Development for Health
Dar es Salaam, Tanzania
|
|
| 41 |
NCT02680613 |
Completed |
Pilot Study of a Mobile Health Approach to Reduce Barriers to Cervical Cancer Screening in Tanzania |
|
- Behavioral: Motivational SMS
- Behavioral: Travel Voucher
|
Interventional
|
Not Applicable |
- Queen's University
- Terry Fox Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Screening
|
- Attendance at Cervical Cancer Screening at clinics included in Trial
- Satisfaction with Smartphone Enhanced Digital Cervicography
|
851 |
Female |
25 Years to 49 Years (Adult) |
NCT02680613 |
Q-6015511 |
KCCPAS |
February 2016 |
May 12, 2016 |
September 2017 |
February 11, 2016 |
January 29, 2018 |
|
- Pamoja Tunaweza Women's Center
Moshi, Kilimanjaro, Tanzania
|
|
| 42 |
NCT02633319 |
Completed |
Malezi Na Kilimo Bora - Skilful Parenting and Agribusiness Child Abuse Prevention Study |
|
- Behavioral: Skilful Parenting
- Other: Agrics
|
Interventional
|
Not Applicable |
- University of Oxford
- Tanzanian National Institute of Medical Research
- University of Glasgow
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Child Abuse - Parent Report
- Change in Child Abuse - Child Report
- Change in Parenting Behaviour - Adult Report
- (and 23 more...)
|
248 |
All |
18 Years and older (Adult, Older Adult) |
NCT02633319 |
SSD/CUREC1A/14-SSH_C2_15_023 |
SPACAPS |
August 1, 2015 |
December 31, 2016 |
March 1, 2017 |
December 17, 2015 |
June 22, 2017 |
|
- Tanzania National Institute of Medical Research
Mwanza, Tanzania
|
|
| 43 |
NCT02613520 |
Completed |
Safety and Immunogenicity in Age De-Escalation of PfSPZ Vaccine in Tanzanian Adults, Children, and Infants |
|
- Biological: PfSPZ Vaccine
- Other: Normal Saline
- Biological: PfSPZ Challenge (for CHMI)
|
Interventional
|
Phase 1 |
- Sanaria Inc.
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
- (and 5 more...)
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence and type of Adverse Events
- Level of Antibodies against Pf proteins in volunteer sera
- Inhibitory Capacity of Volunteer Sera against in vitro Sporozoite Invasion of Hepatocytes
- (and 2 more...)
|
105 |
All |
6 Months to 45 Years (Child, Adult) |
NCT02613520 |
BSPZV2 |
|
December 2015 |
February 2017 |
March 2017 |
November 24, 2015 |
October 15, 2018 |
|
- Bagamoyo Research and Training center of the Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 44 |
NCT02592252 |
Recruiting |
Impact of Microfinance and Participatory Gender Training for Women in Reducing Intimate Partner Violence |
- Maltreatment by Spouse or Partner
|
- Behavioral: Participatory gender training
- Other: Microfinance
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- Mwanza Intervention Trials Unit
- National Institute for Medical Research, Tanzania
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Past 12 months exposure to intimate partner violence
|
2640 |
Female |
20 Years to 50 Years (Adult) |
NCT02592252 |
QA430 |
MAISHA |
September 2014 |
July 2019 |
December 2019 |
October 30, 2015 |
March 26, 2018 |
|
- Mawanza Intervention Trials Unit
Mwanza, Tanzania
|
|
| 45 |
NCT02561624 |
Completed |
Hati Salama (Secure Voucher) |
|
- Behavioral: Behaviour change communication via text message
|
Interventional
|
Not Applicable |
- Queen's University
- Mennonite Economic Development Associates
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Increased uptake of long-lasting insecticide treated nets from retailers using an electronic voucher through text messaging.
|
5219 |
Female |
18 Years to 50 Years (Adult) |
NCT02561624 |
DMED-1712-14 |
|
July 2015 |
January 2016 |
January 2016 |
September 28, 2015 |
April 13, 2016 |
|
- Pamoja Tunawez
Moshi, Tanzania
|
|
| 46 |
NCT02545296 |
Completed |
HIV Point-of-Care Test Evaluation in Infants |
|
- Other: In-vitro Diagnostics
|
Interventional
|
Not Applicable |
- Michael Hoelscher
- German Center for Infection Research
- Ludwig-Maximilians - University of Munich
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Specificity of PoC HIV test
- Sensitivity of PoC HIV test
|
604 |
All |
up to 48 Hours (Child) |
NCT02545296 |
LMU-IMPH-BABY-01 |
BABY |
July 2015 |
October 2016 |
August 2017 |
September 9, 2015 |
March 7, 2018 |
|
- NIMR - Mbeya Medical Research Centre
Mbeya, Tanzania
|
|
| 47 |
NCT02541708 |
Active, not recruiting |
IV Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Iron Deficiency Anemia at Delivery in Tanzania |
|
- Drug: Ferric carboxymaltose
- Drug: Ferrous sulfate + folic acid
|
Interventional
|
Phase 3 |
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage of women with correction of hemoglobin to normal values (Hb> 11.5g/dl) at 6 weeks by treatment arm
- Best response (Hemoglobin) in grams per decilitre (g/dl)
- Percentage of women with corrected iron deficiency (Ferritin>50ng/ml) in each arm
- (and 7 more...)
|
230 |
Female |
18 Years to 49 Years (Adult) |
NCT02541708 |
IFCIDA 001-2015 |
Ferinject |
September 2015 |
April 2018 |
April 2018 |
September 4, 2015 |
April 25, 2017 |
|
- Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 48 |
NCT02533336 |
Terminated |
The Effectiveness of Non-Pyrethroid Insecticide-Treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania |
|
- Drug: abamectin and fenpyroximate
|
Interventional
|
Phase 3 |
- National Institute for Medical Research, Tanzania
- Kilimanjaro Christian Medical Centre, Tanzania
- London School of Hygiene and Tropical Medicine
- (and 3 more...)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Incidence of malaria parasitemia
- Effectiveness of DL on anemia
|
4917 |
All |
6 Months to 11 Years (Child) |
NCT02533336 |
DL Project in Tanzania |
DL |
November 9, 2015 |
August 31, 2016 |
March 31, 2017 |
August 26, 2015 |
February 5, 2019 |
|
- Muheza
Tanga, Muheza, Tanzania
|
|
| 49 |
NCT02506413 |
Recruiting |
Replicating MamaToto in Rural Tanzania |
- Maternal Death
- Newborn Death
|
|
Interventional
|
Not Applicable |
- University of Calgary
- Catholic University of Health and Allied Sciences
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of live births attended by a skilled health provider
- Proportion of women receiving postnatal care <48H
- Proportion of women receiving antenatal care 4 or more times during pregnancy
|
5000 |
All |
15 Years and older (Child, Adult, Older Adult) |
NCT02506413 |
IRT #39 |
|
April 2016 |
June 2020 |
December 2020 |
July 23, 2015 |
July 26, 2018 |
|
- Catholic University of Health and Allied Sciences
Mwanza, Tanzania
|
|
| 50 |
NCT02318420 |
Active, not recruiting |
The PartoMa Project: For Improving Monitoring, Action and Triage During Labour |
- Obstetric Labor Complications
- Stillbirth
- Maternal Death
|
- Other: The PartoMa intervention
|
Interventional
|
Not Applicable |
- Ib Christian Bygbjerg
- University of Copenhagen
- Rigshospitalet, Denmark
- (and 4 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Composite outcome of stillbirths and birth asphyxia
- Maternal death
- Cesarean sections and vacuum extractions
- (and 4 more...)
|
3087 |
All |
Child, Adult, Older Adult |
NCT02318420 |
R164-2013-16038 |
PartoMa |
October 1, 2014 |
March 1, 2016 |
July 1, 2018 |
December 17, 2014 |
July 2, 2017 |
|
- Dept. Obstetrics and Gynaecology, Mnazi Mmoja Hospital
Zanzibar City, Zanzibar, Tanzania
|
|
| 51 |
NCT02315352 |
Completed
Has Results |
Cross-over Study to Evaluate the Palatability of New Orally Disintegrating Tablets (ODTs) of Praziquantel (PZQ) and L-PZQ Versus Current PZQ Tablets in African Children Age 6-11 Years |
|
- Drug: L-PZQ ODT
- Drug: Rac-PZQ ODT
- Drug: Cesol®
|
Interventional
|
Phase 1 |
- Merck KGaA, Darmstadt, Germany
- Swiss Tropical & Public Health Institute
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
|
- Overall Palatability Visual Analogue Scale (VAS) Score at 0 Minute (Right After the Spit-out of the Investigational Medicinal Product [IMP])
- Overall Palatability VAS Score at 2-5 Minutes
- Number of Subjects With Mouth Feeling and Taste Description Evaluation
- Number of Subjects With Discomfort or Observations Relating to Acceptance of the Study Medication
|
48 |
All |
6 Years to 11 Years (Child) |
NCT02315352 |
EMR200661-002 |
|
April 2015 |
May 2015 |
May 2015 |
December 11, 2014 |
March 6, 2017 |
March 6, 2017 |
- Ifakara Health Institute
Ikwiriri, Rufiji, Tanzania
|
|
| 52 |
NCT02305927 |
Active, not recruiting |
Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health |
|
- Dietary Supplement: Vitamin D3 (cholecalciferol)
- Other: Placebo
|
Interventional
|
Phase 3 |
- Wafaie Fawzi
- Management and Development for Health (MDH)
- Harvard School of Public Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Proportion of participants experiencing maternal HIV progression
- Proportion of small-for-gestational age infants
- Proportion of stunted infants (height-for-age z-score < -2)
|
2300 |
Female |
18 Years and older (Adult, Older Adult) |
NCT02305927 |
R01HD083113 |
ToV5 |
June 2015 |
June 2019 |
June 2019 |
December 3, 2014 |
April 18, 2018 |
|
- Management and Development for Health (MDH)
Dar es Salaam, Tanzania
|
|
| 53 |
NCT02298140 |
Unknown † |
Providers' Compliance to Malaria Treatment |
|
|
Interventional
|
Not Applicable |
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
- KEMRI-Wellcome Trust Collaborative Research Program
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Provider Compliance
- Number of fever patients who received diagnostic test
- Number of confirmed malaria patients treated with recommended antimalaria
- (and 5 more...)
|
712 |
All |
Child, Adult, Older Adult |
NCT02298140 |
3245 |
(PCMT) |
November 2014 |
December 2015 |
December 2015 |
November 21, 2014 |
August 3, 2015 |
|
- Ifakara Health Institute
Rufiji, Pwani, Tanzania
|
|
| 54 |
NCT02294214 |
Withdrawn |
Spatial Repellent Products for the Control of Vector Borne Diseases - Malaria - Tanzania |
|
- Device: Spatial Repellent product with active ingredient
- Device: Active ingredient
- Device: Spatial Repellent product without active ingredient (SHIELD)
|
Interventional
|
Not Applicable |
- University of Notre Dame
- Ifakara Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
0 |
All |
6 Months to 59 Months (Child) |
NCT02294214 |
SR-M-TZ |
SR-M-Tz |
February 2016 |
April 2016 |
April 2016 |
November 19, 2014 |
October 6, 2016 |
|
- Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 55 |
NCT02288637 |
Completed |
Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product |
|
- Other: Olyset Plus LLIN
- Other: Conventional Olyset LLIN
- Other: IRS
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Difference in prevalence of malaria infection in children 0.5-14 years between intervention arms
- Difference in Entomological Inoculation Rate
- Difference in Anaemia in children
- (and 4 more...)
|
3840 |
All |
6 Months to 14 Years (Child) |
NCT02288637 |
ITDCZC58 |
|
September 2014 |
December 2017 |
April 2018 |
November 11, 2014 |
April 27, 2018 |
|
- District Muleba
Muleba, Kagera, Tanzania
|
|
| 56 |
NCT02281578 |
Active, not recruiting |
Community-based Combination HIV Prevention in Tanzanian Women |
|
- Behavioral: Community-based combination HIV prevention intervention
- Behavioral: Standard of care HIV services
|
Interventional
|
Not Applicable |
- Johns Hopkins Bloomberg School of Public Health
- Muhimbili University of Health and Allied Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- HIV incidence
- Viral load suppression
- Consistent condom use
- Adherence to ART
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02281578 |
R01MH104044 |
|
January 2015 |
June 30, 2017 |
June 30, 2017 |
November 3, 2014 |
March 7, 2017 |
|
|
|
| 57 |
NCT02259166 |
Completed |
Enhanced Homestead Food Production Plus+ Program in the Lake Zone, Tanzania |
|
|
Interventional
|
Not Applicable |
- International Food Policy Research Institute
- Helen Keller International
- Foreign Affairs, Trade and Development, Canada
- National Institute for Medical Research, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Anemia (g/dl and %)
- Growth (Z-score and %)
- Biochemical markers
- (and 5 more...)
|
2325 |
All |
6 Months to 12 Months (Child) |
NCT02259166 |
EHFP+ TZ |
|
June 2014 |
March 2016 |
March 2016 |
October 8, 2014 |
September 19, 2016 |
|
- National Institute for Medical Research
Mwanza, Tanzania
|
|
| 58 |
NCT02249754 |
Unknown † |
Nutrition Education Package for Infants and Young Child Feeding and Health in Rural Tanzania |
- Growth Retardation
- Malnutrition
|
- Behavioral: Nutrition education
- Behavioral: Routine health education
|
Interventional
|
Not Applicable |
- Sokoine University of Agriculture
- University Ghent
- Institute of Tropical Medicine, Belgium
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Linear growth: Mean change from baseline in length-for-age Z-scores at at 9-, 12- and 15-months-old
- Weight-for-length: Mean change from baseline in weight-for-length Z-scores at 9-, 12- and 15-months-old
- Mean intake of energy, fat, iron and zinc from complementary foods at 12 months-old
- (and 3 more...)
|
600 |
All |
6 Months to 7 Months (Child) |
NCT02249754 |
879/13 |
NECTAc |
September 2014 |
August 2015 |
August 2015 |
September 26, 2014 |
November 19, 2014 |
|
- Mpwapwa District
Mpwapwa, Dodoma, Tanzania
|
|
| 59 |
NCT02229474 |
Completed
Has Results |
IDEA Study Cognitive Stimulation Therapy (CST) Trial in Tanzania |
|
- Behavioral: CST Intervention
|
Interventional
|
Not Applicable |
- William Keith Gray
- Grand Challenges Canada
- University of Ibadan
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- World Health Organization Brief Quality of Life Scale
- Identification and Intervention for Elderly Africans Cognitive Screen
- Adapted Alzheimer's Disease Assessment Scale-cognitive Scale
- (and 2 more...)
|
34 |
All |
Child, Adult, Older Adult |
NCT02229474 |
IDEA_TANZANIA_CST1 |
IDEA |
September 2014 |
May 2015 |
September 2015 |
September 1, 2014 |
April 9, 2018 |
April 9, 2018 |
- Hai district DSS
Moshi, Kilimanjaro, Tanzania
|
|
| 60 |
NCT02225769 |
Completed |
Electronic Algorithms Based on Host Biomarkers to Manage Febrile Children |
|
- Other: Management of febrile children using e-POCT
- Other: Management of febrile children using ALMANACH
|
Interventional
|
Not Applicable |
- Swiss Tropical & Public Health Institute
- Swiss National Science Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Proportion of clinical failure by day 7 compared among the 3 study arms.
- Proportions of secondary hospitalization and death by day 30 compared among the 3 study arms.
- Proportions of children prescribed an antibiotic and/or antimalarial treatment at day 0 and by day 7 compared among the 3 study arms.
- (and 2 more...)
|
3192 |
All |
2 Months to 59 Months (Child) |
NCT02225769 |
IZ01Z0_146896 |
e-POCT |
December 2014 |
February 2016 |
February 2016 |
August 26, 2014 |
October 12, 2016 |
|
- Rangi tatu, Magomeni and Tandale health centers
Dar es Salaam, Tanzania
|
|
| 61 |
NCT02191683 |
Active, not recruiting |
Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later |
- Anemia and Pregnancy
- Metabolism and Foetal Growth
- Epigenetics
|
|
Observational
|
|
- University of Copenhagen
- Copenhagen University Hospital, Denmark
- Aarhus University Hospital
- (and 3 more...)
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Outcome parameter for the pre-pregnancy study (i.):
- Outcome parameter for the pregnancy study (ii.):
- Incidence of conception among non-pregnant Tanzanian women.
|
1748 |
Female |
18 Years to 40 Years (Adult) |
NCT02191683 |
1309-00003B
Strategiske Forskningsråd |
FOETALforNCD |
July 2014 |
December 2017 |
October 2018 |
July 16, 2014 |
May 23, 2017 |
|
- National Institute for Medical research
Korogwe, Tanga Region, Tanzania
|
|
| 62 |
NCT02180750 |
Unknown † |
Phase II Randomised Controlled Trial of Memory Work Therapy at PASADA, Tanzania |
|
- Other: Memory Work Therapy
- Other: Standard care
|
Interventional
|
Not Applicable |
- Pastoral Activities and Service for AIDS Dar-Es-Salaam Archdiocese
- University of Cape Town
- King's College London
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change: Brief Symptom Inventory
- Change: Rosenberg Self-Esteem Scale
- Change: Goodman's strengths and difficulties questionnaire
- Change: Self-efficacy questionnaire for children
|
48 |
All |
14 Years to 18 Years (Child, Adult) |
NCT02180750 |
MWT01 |
MWT |
June 2013 |
July 2014 |
August 2014 |
July 3, 2014 |
July 3, 2014 |
|
|
|
| 63 |
NCT02176772 |
Completed |
Iron Absorption and Utilization During Tuberculosis and After Treatment |
|
- Other: Stable iron isotopes, non-drug intervention
|
Observational
|
|
- Swiss Federal Institute of Technology
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
|
Other |
- Observational Model: Case-Crossover
- Time Perspective: Prospective
|
- Change from baseline in iron absorption of stable isotope tracers at week 8
- Change from baseline in iron incorporation of stable isotope tracers at week 8
- Change from baseline in iron absorption of stable isotope tracers at week 24
- (and 14 more...)
|
19 |
All |
18 Years to 45 Years (Adult) |
NCT02176772 |
Fe_TB_Study_TZ |
|
April 2015 |
January 2017 |
January 2017 |
June 27, 2014 |
June 5, 2017 |
|
- Tb-clinic, Bagamoyo Research and Training Centre
Bagamoyo, Pwani, Tanzania
|
|
| 64 |
NCT02168985 |
Unknown † |
Impact Evaluation Study of The Faithful House Programme on Violence Reduction in Families |
|
|
Interventional
|
Not Applicable |
- Savannas Forever Tanzania
- National Institute for Medical Research, Tanzania
- Arusha Lutheran Medical Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of violence against or witnessed by children insults, and threats of physical harm and abandonment in the past three months and similar violent acts between partners that are observed by their children ages 10-17.
- Attitudes about violence
|
300 |
All |
Child, Adult, Older Adult |
NCT02168985 |
SFTZ-C&VECF |
TFHEVAL |
July 2014 |
October 2014 |
February 2015 |
June 20, 2014 |
July 8, 2014 |
|
- Arusha Lutheran Medical Centre
Arusha, Arusha Region, Tanzania
|
|
| 65 |
NCT02167776 |
Completed |
From Obstacles to Opportunities for Male Circumcision in Tanzania |
|
- Behavioral: Church-based teaching
|
Interventional
|
Not Applicable |
- Weill Medical College of Cornell University
- Bill and Melinda Gates Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- rate of uptake of male circumcision
- qualitative data from church attenders in intervention and control villages
|
43 |
Male |
Child, Adult, Older Adult |
NCT02167776 |
1107011800 |
|
June 2014 |
December 2015 |
December 2015 |
June 19, 2014 |
January 11, 2017 |
|
- Bugando Medical Centre and catchment area
Mwanza, Tanzania
|
|
| 66 |
NCT02162875 |
Completed |
Schistosoma Mansoni in Mwanza Region, Tanzania |
|
|
Interventional
|
Not Applicable |
- DBL -Institute for Health Research and Development
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of Mass drug administration on prevalence and intensity of Schistosoma mansoni among children and adults
- Mass drug administration coverage
|
37500 |
All |
7 Years to 55 Years (Child, Adult) |
NCT02162875 |
TAN-score
BMGF |
SCORE_PAR |
March 2011 |
January 2017 |
January 2017 |
June 13, 2014 |
February 10, 2017 |
|
- National Institute for Mediacal Research
Mwanza, Lake Region, Tanzania
|
|
| 67 |
NCT02132299 |
Completed |
Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults |
- Malaria
- Plasmodium Falciparum Malaria
|
- Biological: PfSPZ Vaccine
- Biological: Normal Saline (Placebo)
- Biological: PfSPZ Challenge
|
Interventional
|
Phase 1 |
- Sanaria Inc.
- Ifakara Health Institute
- Swiss Tropical & Public Health Institute
- Tanzania Commission for Science and Technology
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Safety and tolerability endpoints
- Protective Efficacy after CHMI with PfSPZ Challenge (NF54) - CHMI Endpoints
- Immune Responses after PfSPZ Vaccine
- Protective effect of the high dose PfSPZ Vaccine regimen
|
67 |
Male |
18 Years to 35 Years (Adult) |
NCT02132299 |
BSPZV1 |
|
April 2014 |
July 2015 |
August 2015 |
May 7, 2014 |
April 27, 2016 |
|
- Bagamoyo Research and Training Center, Ifakara Health Institute, Kingani Estate, PO Box 74
Bagamoyo, Tanzania
|
|
| 68 |
NCT02120742 |
Completed |
The Impact Of Text Message (SMS) Reminders On Helmet Use Among Motorcycle Drivers In Dar Es Salaam, Tanzania |
- Road Traffic Injury Prevention
- Helmet Use
- mHealth Intervention
|
- Behavioral: SMS message reminder
|
Interventional
|
Not Applicable |
- Amend
- Dartmouth-Hitchcock Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Self-reported adherence to helmet use
- Attitude change
|
391 |
Male |
18 Years and older (Adult, Older Adult) |
NCT02120742 |
D14103 |
|
April 2014 |
June 2014 |
September 2015 |
April 23, 2014 |
September 30, 2015 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Upanga West, Tanzania
|
|
| 69 |
NCT02090036 |
Completed |
Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes |
|
- Drug: Primaquine (For artemether-lumefantrine+primaquine arm)
- Drug: Placebo (For artemether-lumefantrine arm)
|
Interventional
|
Phase 4 |
- Muhimbili University of Health and Allied Sciences
- Karolinska Institutet
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Number of days per treatment arm for gametocytes to become undetectable using Quantitative nucleic acid sequence based assay (QT-NASBA).
- Mean maximal fall in hemoglobin (g/dl) from enrolment to day 28 of follow-up defined as mean greatest negative difference in hemoglobin per treatment arm.
|
220 |
All |
1 Year and older (Child, Adult, Older Adult) |
NCT02090036 |
1.0.2014 |
|
July 2014 |
October 2014 |
November 2014 |
March 18, 2014 |
December 8, 2014 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 70 |
NCT02089841 |
Completed |
Efficacy of Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria. |
- Plasmodium Falciparum Malaria
|
- Drug: Artemether-lumefantrine
|
Interventional
|
Phase 4 |
- Richard Mwaiswelo
- Karolinska Institutet
- Muhimbili University of Health and Allied Sciences
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients without parasitaemia on day 42.
- Plasma lumefantrine concentration
|
140 |
All |
6 Months to 120 Months (Child) |
NCT02089841 |
3.0.2011 |
ALE |
May 2012 |
August 2013 |
August 2013 |
March 18, 2014 |
March 18, 2014 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 71 |
NCT02039973 |
Completed |
Healthy Options: Group Psychotherapy for HIV-positive Depressed Perinatal Women. |
|
- Behavioral: Task-sharing approach to group therapy
- Behavioral: Enhanced standard of care
|
Interventional
|
Not Applicable |
- Harvard Medical School
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Depressive disorder and suicidality
- Social support
- Self-Efficacy
- (and 7 more...)
|
742 |
Female |
18 Years to 49 Years (Adult) |
NCT02039973 |
1R01MH100338-01 |
|
July 1, 2013 |
December 31, 2017 |
December 31, 2017 |
January 20, 2014 |
February 22, 2018 |
|
- Dar es Salaam City Health Department
Dar es Salaam, Tanzania
|
|
| 72 |
NCT02021799 |
Completed |
The Effect of Under-nutrition on the Human Microbiota |
|
- Dietary Supplement: Moringa and Lactobacillus rhamnosus GR-1
|
Interventional
|
Not Applicable |
- Western University, Canada
- National Institute for Medical Research, Tanzania
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Characterization of gut, oral, vaginal and human milk microbiomes
- Assessment of 48-hour Dietary Recalls
- Changes in body toxin levels
- (and 2 more...)
|
77 |
Female |
18 Years to 40 Years (Adult) |
NCT02021799 |
102400 |
|
August 2012 |
April 2013 |
April 2013 |
December 27, 2013 |
December 27, 2013 |
|
- Nyerere Dispensary
Buswelu, Tanzania
|
|
| 73 |
NCT02018978 |
Completed |
Comprehensive Triaged HIV Prevention in Tanzania |
|
- Behavioral: Comprehensive Triaged HIV Prevention (CTHP)
|
Interventional
|
Phase 2 |
- Medical University of South Carolina
- Muhimbili University of Health and Allied Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- STI Incidence
- Safety and acceptability
- Sexual risk behavior
|
739 |
All |
18 Years to 55 Years (Adult) |
NCT02018978 |
R01MH095869 |
|
October 2013 |
December 2016 |
December 2016 |
December 24, 2013 |
October 24, 2017 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 74 |
NCT01998295 |
Completed |
Parasite Clearance Time and Time to Recurrent Infection Following Treatment With Artemether/Lumefantrine |
|
- Drug: Artemether/lumefantrine
|
Interventional
|
Phase 4 |
- Muhimbili University of Health and Allied Sciences
- Karolinska Institutet
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to parasite clearance
- Time to recurrent infection
|
45 |
All |
6 Months to 120 Months (Child) |
NCT01998295 |
2.0.2011 |
PCT |
May 2012 |
June 2012 |
July 2012 |
November 28, 2013 |
March 18, 2014 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 75 |
NCT01968837 |
Completed |
The Kilimanjaro Cervical Screening Project |
- Uterine Cervical Neoplasms
- Cervical Cancer
|
- Other: Cervical cancer screening
|
Interventional
|
Not Applicable |
- Queen's University
- Grand Challenges Canada
- Kilimanjaro Christian Medical Centre, Tanzania
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Test accuracy of using digital smart phone cervicograms in place of traditional cervicography images produced through traditional SLR cameras
- Measure accuracy and feasibility of non-physician healthcare workers ability to obtain adequate cervical images via smart phone camera photographs.
|
1072 |
Female |
25 Years to 49 Years (Adult) |
NCT01968837 |
DMED-1545-12 |
KCCP |
May 2014 |
September 2015 |
September 2015 |
October 24, 2013 |
April 13, 2016 |
|
- Reproductive Health Centre, KCMC
Moshi, Tanzania
|
|
| 76 |
NCT01947075 |
Completed |
Etiologies of Fever Among Adults in Dar es Salaam |
|
|
Observational
|
|
- Swiss Tropical & Public Health Institute
- Ifakara Health Institute
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of patients with each disease among all febrile patients, overall and stratified by HIV status
- Proportion of febrile patients with acute respiratory infection infected with a certain respiratory pathogen, compared to the proportion of healthy controls infected with the same pathogen.
|
538 |
All |
18 Years and older (Adult, Older Adult) |
NCT01947075 |
Fever Study
Adult Fever Study |
|
July 2013 |
July 2014 |
July 2014 |
September 20, 2013 |
August 21, 2014 |
|
- Mwananyamala Hospital
Dar es Salaam, Tanzania
|
|
| 77 |
NCT01934075 |
Completed |
Development of Mental Health Treatment for Obstetric Fistula Patients in Tanzania |
- Other Obstetric Trauma OS
|
- Behavioral: Mental health treatment
|
Interventional
|
Not Applicable |
- Duke University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Kilimanjaro Christian Medical Centre, Tanzania
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Depression symptoms
- PTSD symptoms
- Anxiety symptoms
|
60 |
Female |
18 Years to 99 Years (Adult, Older Adult) |
NCT01934075 |
R21HD073681 |
|
September 2013 |
August 2016 |
August 2016 |
September 4, 2013 |
August 9, 2016 |
|
- Kilimanjaro Christian Medical Center
Moshi, Tanzania
|
|
| 78 |
NCT01932138 |
Completed |
Trial to Improve Access to PMTCT Services and Reduce HIV Transmission From Mother to Child |
- Mother-to-child Transmission of HIV
- Pregnancy
|
- Other: Enhanced CHW intervention
- Other: Standard of care
|
Interventional
|
Not Applicable |
- Harvard School of Public Health
- Management and Development for Health, Tanzania
- Elton John AIDS Foundation
- Comic Relief UK
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of infants born to HIV-infected mothers who have acquired HIV
- Proportion of HIV-exposed infants tested for HIV
- Proportion of pregnant women making at least four antenatal clinic visits
- (and 6 more...)
|
190530 |
Female |
Child, Adult, Older Adult |
NCT01932138 |
EJF22802 |
FS |
January 2013 |
April 2014 |
April 2014 |
August 30, 2013 |
March 2, 2015 |
|
- Management and Development for Health
Dar es Salaam, Tanzania
|
|
| 79 |
NCT01930331 |
Completed |
Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO |
- Plasmodium Falciparum
- Malaria, Falciparum
|
- Drug: artemisinin/naphthoquine
- Drug: dihydroartemisinin/piperaquine phosphate
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of reported non serious and serious adverse events
- 12-lead ECG recordings: Heart rate, PR interval, QRS duration, QT interval, QTc (Fridericia and Bazett corrections), any T wave or U-wave morphology.
|
60 |
All |
6 Years to 60 Years (Child, Adult) |
NCT01930331 |
IHI |
|
January 7, 2014 |
July 27, 2014 |
June 1, 2015 |
August 28, 2013 |
March 14, 2018 |
|
- Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 80 |
NCT01906788 |
Unknown † |
The Optimal Timing Of Primaquine To Prevent Malaria Transmission After Artemisinin-Combination Therapy |
|
- Drug: Artemether Lumefantrine
- Drug: Artemether Lumefantrine 6 dose regimen & single dose of Primaquine on day 0
- Drug: Artemether Lumefantrine 6 dose regimen and single dose Primaquine on day 2
|
Interventional
|
Phase 4 |
- Kilimanjaro Clinical Research Institute
- London School of Hygiene and Tropical Medicine
- Ifakara Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Gametocyte prevalence and density by microscopy and QT-NASBA
- Haemoglobin level
|
250 |
All |
3 Years to 17 Years (Child) |
NCT01906788 |
PRIMAQUINE STUDY |
|
May 2013 |
October 2013 |
October 2013 |
July 24, 2013 |
July 24, 2013 |
|
- Bagamoyo Research and Training Centre
Bagamoyo, Tanzania
|
|
| 81 |
NCT01904513 |
Completed |
Investigating the Effects of Probiotic Yogurt on Reducing the Levels of Environmental Toxins Among School Children in Mwanza, Tanzania |
|
- Dietary Supplement: Pasteurized Whole Milk
- Dietary Supplement: Lactobacillus rhamnosus GR-1
|
Interventional
|
Not Applicable |
- Western University, Canada
- National Institute for Medical Research, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Changes in Body Toxin Levels
- Changes in Microbiota Composition
- Microbes linked to host toxin levels
- Changes in host metabolism due to probiotic instillation
|
44 |
All |
6 Years to 10 Years (Child) |
NCT01904513 |
102881 |
PDTX |
December 2012 |
December 2012 |
August 2013 |
July 22, 2013 |
December 17, 2013 |
|
- National Institute for Medical Research
Mwanza, Tanzania
|
|
| 82 |
NCT01878279 |
Completed |
HSV Oral Reactivation in Children |
|
- Other: Underlying medical illness
|
Observational
|
|
- Dartmouth-Hitchcock Medical Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- HSV detection rate
- HSV copy number
|
30 |
All |
3 Years to 12 Years (Child) |
NCT01878279 |
21397 |
|
September 2008 |
July 2010 |
|
June 14, 2013 |
June 14, 2013 |
|
- MUHAS
Dar es Salaam, Tanzania
|
|
| 83 |
NCT01869127 |
Completed |
Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar |
|
|
Interventional
|
Not Applicable |
- Bird, Christopher
- London School of Hygiene and Tropical Medicine
- Fondazione Ivo de Carneri, Milan, Italy
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Reduction in hookworm prevalence and intensity of infection in intervention arm
- Use of shoes by children in intervention arm
|
1056 |
All |
7 Years to 17 Years (Child) |
NCT01869127 |
SKIP48039353950 |
SKIP |
July 2011 |
October 2012 |
October 2012 |
June 5, 2013 |
June 5, 2013 |
|
- Public Health Laboratory
Chake Chake, Pemba Island, Zanzibar, Tanzania
|
|
| 84 |
NCT01821222 |
Completed |
Wired Mothers - Use of Mobile Phones to Improve Maternal and Neonatal Health in Zanzibar |
- Pregnancy
- Maternal Health
- Newborn Death
- (and 2 more...)
|
|
Interventional
|
Not Applicable |
- University of Copenhagen
- Ministry of Health and Social Welfare, Zanzibar
- Danish International Development Cooperation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Skilled delivery attendance
- Perinatal mortality
- Antenatal care attendance
|
2550 |
Female |
14 Years to 45 Years (Child, Adult) |
NCT01821222 |
09-086KU |
|
February 2009 |
April 2010 |
April 2010 |
March 29, 2013 |
March 29, 2013 |
|
- 24 Primary Healthcare Facilities on the island on Unguja
Zanzibar, Tanzania
|
|
| 85 |
NCT01798680 |
Active, not recruiting |
Trial of Vitamin D in HIV Progression |
|
- Dietary Supplement: Vitamin D3 (cholecalciferol)
- Other: Placebo
|
Interventional
|
Phase 3 |
- Harvard School of Public Health
- Management and Development for Health (MDH)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- All-cause death
- Pulmonary tuberculosis
- CD4+ T-cell count
- (and 9 more...)
|
4000 |
All |
18 Years and older (Adult, Older Adult) |
NCT01798680 |
R01DK098075 |
TOV4 |
February 2014 |
March 2018 |
March 2019 |
February 26, 2013 |
April 18, 2018 |
|
- Management and Development for Health (MDH)
Dar es Salaam, Tanzania
|
|
| 86 |
NCT01746758 |
Unknown † |
Mobile Phone Text Messaging Referral |
- HIV
- Sexually Transmitted Infections
- Contraception
- Pregnancy
|
- Behavioral: SMS text messaging referral
|
Interventional
|
Not Applicable |
- Liverpool School of Tropical Medicine
- National Institute for Medical Research, Tanzania
- Ministry of Health and Social Welfare, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Increase the number of patients receiving reproductive health services at dispensary and health centre level after referral from a drug store.
- Referred number of patients attending HIV, STI, pregnancy prevention (including numbers of condoms, VCT, and post-abortion care) and treatment
- Referred number of patients attending other contraceptives (the pill, intra-uterine devices, injection, female condom and sterilisation where available)
- (and 3 more...)
|
700 |
All |
15 Years to 19 Years (Child, Adult) |
NCT01746758 |
11.94RS |
SMS4Health |
August 2012 |
January 2014 |
January 2014 |
December 11, 2012 |
December 11, 2012 |
|
- National Institute for Medical Research Tanzania
Mwanza, Tanzania
|
|
| 87 |
NCT01733537 |
Completed |
Improving Motorcycle Taxi Driver Visibility in Tanzania |
|
- Other: Free reflective, fluorescent vest
- Behavioral: Education
|
Interventional
|
Not Applicable |
- Duke University
- Kilimanjaro Christian Medical Centre, Tanzania
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Use of reflective or fluorescent clothing
- Wearing White Helmet
- Daytime Running Headlights
|
180 |
All |
18 Years and older (Adult, Older Adult) |
NCT01733537 |
Pro00034415
1R25TW009337-01 |
|
February 2013 |
June 2013 |
June 2013 |
November 27, 2012 |
August 9, 2013 |
|
- Kilimanjaro Region, Tanzania
Kilimanjaro Region, Tanzania
|
|
| 88 |
NCT01718054 |
Unknown † |
Vascular Function Intervention Trial in Sickle Cell Disease |
|
- Dietary Supplement: Vascular ready-to-use supplementary food
- Dietary Supplement: Regular Ready-to-use supplementary food
- Drug: Chloroquine
|
Interventional
|
Phase 2
Phase 3 |
- London School of Hygiene and Tropical Medicine
- Wellcome Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- ratio of arginine to ornithine concentration & ratio of arginine to ADMA
- Nitric Oxide dependent endothelial function
- Linear Growth and Weight Gain
- (and 6 more...)
|
120 |
All |
8 Years to 11 Years (Child) |
NCT01718054 |
VFIT001
WT094780 |
V-FIT |
August 2012 |
September 2016 |
September 2017 |
October 31, 2012 |
July 27, 2016 |
|
- Muhimbili University of Heath and Allied Sciences (MUHAS)
Dar es Salaam, Tanzania
|
|
| 89 |
NCT01699841 |
Completed |
Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events |
- HIV
- Malnutrition
- Cryptosporidiosis
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Breast milk composition
- Infant anthropometric measures
- Infant infectious disease events
|
208 |
All |
Child, Adult, Older Adult |
NCT01699841 |
IRB 1111002616 |
|
April 2012 |
June 15, 2013 |
June 30, 2013 |
October 4, 2012 |
November 1, 2017 |
|
- Kisesa Health Centre
Kisesa, Tanzania
|
|
| 90 |
NCT01697852 |
Unknown † |
The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention |
|
- Other: Indoor residual spraying with bendiocarb
- Other: LLIN by universal coverage campaign
|
Interventional
|
Phase 4 |
- London School of Hygiene and Tropical Medicine
- National Institute for Medical Research, Tanzania
- Kilimanjaro Christian Medical Centre, Tanzania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Prevalence of malarial infection in children 6 months to 10 years
- Moderate to severe anaemia in children under 5 years
- Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years
|
22300 |
All |
6 Months to 14 Years (Child) |
NCT01697852 |
ITDCVP54 |
|
January 2011 |
November 2012 |
December 2012 |
October 2, 2012 |
October 3, 2012 |
|
- PAMVERC office
Muleba, Kagera, Tanzania
|
|
| 91 |
NCT01693458 |
Completed |
Positive Change Agents Program-Tanzania (Evaluation) |
|
- Behavioral: Appreciative Inquiry Change Agents (CA) program (NAMWEZA)
|
Interventional
|
Phase 3 |
- Harvard School of Public Health
- Harvard Medical School
- Muhimbili University of Health and Allied Sciences
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HIV Testing or other related-services for network members of HIV Positive change agents.
- Depressive symptoms
|
1046 |
All |
18 Years and older (Adult, Older Adult) |
NCT01693458 |
TZ.08.0147 |
|
April 2011 |
January 2014 |
September 2014 |
September 26, 2012 |
October 20, 2015 |
|
- Muhimbili University of Health and Allied Sciences
Dar Es Salaam, Tanzania
|
|
| 92 |
NCT01647841 |
Completed |
Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth |
- HIV
- Pregnancy
- Malnutrition
- Cachexia
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Maternal cachexia score
- Maternal anthropometric measures
- Fetal growth
- (and 2 more...)
|
218 |
All |
Child, Adult, Older Adult |
NCT01647841 |
IRB 1111002615 |
|
April 2012 |
June 2013 |
July 2013 |
July 24, 2012 |
September 27, 2013 |
|
- Kisesa Health Centre
Kisesa, Tanzania
|
|
| 93 |
NCT01635153 |
Completed |
Effects of a Protein Calorie Supplement in HIV-infected Women With Tuberculosis |
|
- Dietary Supplement: Protein calorie supplement
- Dietary Supplement: Micronutrient
|
Interventional
|
Phase 2 |
- Dartmouth-Hitchcock Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in CD4 count
- BMI at 6 months
- Proportion of subjects who achieve 100 cell increase in CD4
|
151 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01635153 |
DarDar 2-C CPHS 21592
RO1 503498 |
DarDar |
May 2012 |
July 2014 |
July 2014 |
July 9, 2012 |
February 10, 2015 |
|
- Infectious Disease Centre
Dar es Salaam, Tanzania
|
|
| 94 |
NCT01548456 |
Completed |
Nails Versus Plates for Femur Fractures in Dar es Salaam, Tanzania |
|
- Procedure: Intramedullary Nailing
- Procedure: Open Reduction Internal Fixation
|
Observational
|
|
- University of California, San Francisco
- Orthopaedic Research Foundation
- Orthopaedic Trauma Association
- Muhimbili Orthopaedic Institute
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Reoperation
- Health-related quality of life
- Return to work
- (and 2 more...)
|
332 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01548456 |
UCSF 23346 |
|
July 2012 |
July 2014 |
July 2014 |
March 8, 2012 |
May 19, 2015 |
|
- Muhimbili Orthopaedic Institute
Dar es Salaam, Tanzania
|
|
| 95 |
NCT01540903 |
Completed |
Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults |
|
- Biological: PfSPZ Challenge
- Biological: Saline
|
Interventional
|
Phase 1 |
- Sanaria Inc.
- Ifakara Health Research and Development Centre
- Swiss Tropical & Public Health Institute
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Diagnostic
|
- Number of volunteers positive in each group through day 28 of follow up.
- Time from inoculation until first positive parasitemia by thick smear in each volunteer in the two groups.
- Time from inoculation to until first positive parasitemia by qRT-PCR in each volunteer in the two groups.
- (and 2 more...)
|
30 |
Male |
20 Years to 35 Years (Adult) |
NCT01540903 |
BSPZC1 |
|
February 2012 |
September 2012 |
August 2013 |
February 29, 2012 |
September 10, 2014 |
|
- Bagamoyo Research and Training Center, Ifakara Health Institute
Bagamoyo, Tanzania
|
|
| 96 |
NCT01528852 |
Unknown † |
Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis |
- Neonatal Mortality
- Cord Care
- Omphalitis
|
- Drug: Chlorhexidine 4%
- Other: Control cord cleaning solution
|
Interventional
|
Phase 3 |
- Johns Hopkins Bloomberg School of Public Health
- Annamalai University
- Ministry of Health and Social Welfare, Zanzibar
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Neonatal Mortality
- Omphalitis
|
28000 |
All |
up to 48 Hours (Child) |
NCT01528852 |
00003027 |
CHX-Pemba |
October 2010 |
December 2013 |
December 2013 |
February 8, 2012 |
February 8, 2012 |
|
- PHL-IDC
Pemba, Zanzibar, Tanzania
|
|
| 97 |
NCT01461863 |
Completed
Has Results |
DarDar Nutrition Study in HIV Breastfeeding Women |
|
- Dietary Supplement: Porridge protein calorie supplement
- Dietary Supplement: multivitamin
|
Interventional
|
Not Applicable |
- Dartmouth-Hitchcock Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Muhimbili University of Health and Allied Sciences
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Infant Weight
- Maternal BMI at 9 Months
|
96 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01461863 |
R01HD057614-03
R01HD057614 |
DarDar2B |
October 2011 |
December 2013 |
December 2013 |
October 28, 2011 |
August 14, 2018 |
August 14, 2018 |
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 98 |
NCT01461447 |
Completed |
Safety Study of an Additional MVA Vaccine in Volunteers Who Received 3 DNA Vaccines Followed by 2 MVA Vaccines |
|
- Biological: Modified Vaccinia Ankara
|
Interventional
|
Phase 1
Phase 2 |
- Muhimbili University of Health and Allied Sciences
- Karolinska Institutet
- Swedish Institute for Infectious Disease Control
- Walter Reed Army Institute of Research (WRAIR)
|
Other / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Proportion of volunteers with humoral and cellular immune responses elicited by 2 different immunization schedules (id or im DNA priming) prior to MVA boosting
- Safety assessed by the number of solicited and non solicited adverse events following immunization
- Number of staff trained and able to conduct HIV-related vaccine studies at MUHAS.
|
20 |
All |
18 Years to 45 Years (Adult) |
NCT01461447 |
HIVIS 06 |
HIVIS06 |
March 2012 |
May 2012 |
May 2012 |
October 28, 2011 |
May 24, 2012 |
|
- Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
|
| 99 |
NCT01412580 |
Completed |
In Utero Capacity Formation and Socio-economic Outcomes |
|
- Other: observational follow-up
|
Observational
|
|
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
- Children's Cognitive Development
- Children's Health
- Parental Postnatal Investment Behavior
- (and 2 more...)
|
4000 |
All |
18 Years to 49 Years (Adult) |
NCT01412580 |
F19899-101 |
CDS |
April 2002 |
September 2012 |
September 2013 |
August 9, 2011 |
March 27, 2017 |
|
- MUHAS
Dar es Salaam, Tanzania
|
|
| 100 |
NCT01299948 |
Completed |
Progression of HIV-Disease Under Low Dose Corticosteroids |
|
|
Interventional
|
Phase 2 |
- Medical Mission Institute, Germany
- German Leprosy and Tuberculosis Relief Association
- University of Wuerzburg
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to progression of HIV disease
- stabilisation of CD4 count
- Overall survival
- (and 3 more...)
|
326 |
All |
18 Years and older (Adult, Older Adult) |
NCT01299948 |
ProCort1 |
ProCort1 |
June 2007 |
March 2011 |
May 2012 |
February 21, 2011 |
March 22, 2013 |
|
- Bugando Medical Center
Mwanza, Tanzania
|
|
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