1 |
NCT03756467 |
Recruiting |
Girl Empower: Studying the Impact of Mentorship, Asset Building, Caregiver Discussion Groups, and Cash Transfers on Reducing Girl's Vulnerability to Sexual Exploitation and Abuse |
- Adolescent Behavior
- Sexual Violence
|
- Behavioral: Girl Empower Program
|
Interventional
|
Not Applicable |
- Population Council
- World Bank
- International Rescue Committee
- City University of New York
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Health Services Research
|
|
2200 |
Female |
13 Years to 14 Years (Child) |
NCT03756467 |
645 |
|
July 12, 2017 |
December 31, 2018 |
December 31, 2018 |
November 28, 2018 |
November 29, 2018 |
|
- University of Liberia
Monrovia, Liberia
|
|
2 |
NCT03683745 |
Recruiting |
Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia |
- Leprosy
- Buruli Ulcer
- Yaws
- Lymphatic Filariases
|
|
Observational
|
|
- London School of Hygiene and Tropical Medicine
- AIM Initiative
- Liberia Ministry of Health
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Population prevalence of Lymphatic Filariasis
- Population prevalence of Yaws
- Population prevalence of Buruli Ulcer
- (and 3 more...)
|
48000 |
All |
Child, Adult, Older Adult |
NCT03683745 |
14698-1 |
|
June 14, 2018 |
October 30, 2018 |
December 30, 2018 |
September 25, 2018 |
September 25, 2018 |
|
- Maryland County
Harper, Maryland, Liberia
|
|
3 |
NCT03309020 |
Recruiting |
PREVAIL VII: Persistence of Ebola Virus in Aqueous Humor and Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease |
|
|
Observational
|
|
- National Eye Institute (NEI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The proportion of EVD survivors with evidence of persistence of Ebola viral RNA in ocular tissue
- Comparison of amount of intraocular inflammation, as measured by average grade of anterior chamber cell by SUN criteria, between EVD survivors and controls at 1 month and 3 months following cataract surgery.
- Proportion of survivors with at least 20/40 best corrected visual acuity after cataract surgery, relative to controls
- (and 2 more...)
|
120 |
All |
14 Years and older (Child, Adult, Older Adult) |
NCT03309020 |
999917167 17-EI-N167 |
|
February 25, 2019 |
December 31, 2019 |
December 31, 2019 |
October 13, 2017 |
February 20, 2019 |
|
- JFK Hospital
Monrovia, Liberia
|
|
4 |
NCT03098862 |
Recruiting |
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine Response |
|
|
Observational
|
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Other
|
- Identify genetic variation associated with risk of contracting clinical Ebola Virus Disease when directly exposed to the Ebola virus
- Identify genetic variation associated with mortality from Ebola VirusDisease
- Identify genetic variation associated with post recovery Ebola viral RNA persistence in bodily fluids
- (and 2 more...)
|
9000 |
All |
3 Years to 99 Years (Child, Adult, Older Adult) |
NCT03098862 |
999917077 17-I-N077 |
|
February 25, 2019 |
April 30, 2021 |
April 30, 2022 |
April 4, 2017 |
February 20, 2019 |
|
- PREVAIL JFK Medical Center
Monrovia, Liberia
|
|
5 |
NCT02852291 |
Active, not recruiting |
Parents Make the Difference II: Trial of a Parenting Intervention |
|
- Behavioral: Parents Make the Difference
- Behavioral: Parents Make the Difference Plus
|
Interventional
|
Not Applicable |
- Duke University
- International Rescue Committee
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Caregiver use of harsh discipline practices; assessed using Discipline Interview, Locally-derived items
- Parent-Child Interactions (Parental Acceptance-Rejection Questionnaire; Locally-derived items assessing positive interactions)
- Child social-emotional development and functioning: Ages and Stages Questionnaire; Strengths and Difficulties Questionnaire: emotion problems and peer problems subscales
- (and 7 more...)
|
816 |
All |
18 Years and older (Adult, Older Adult) |
NCT02852291 |
pmd2 |
|
March 2016 |
November 2018 |
December 2018 |
August 2, 2016 |
October 13, 2017 |
|
- International Rescue Committee
Monrovia, Liberia
|
|
6 |
NCT02448745 |
Completed |
Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL) |
- Malaria, Falciparum
- Anemia
|
- Device: Insecticide treated wall lining
|
Interventional
|
Not Applicable |
- The Mentor Initiative
- Ministry of Health, Liberia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Malaria Prevalence
- Hemoglobin
- Fever
- Mosquito biting rate.
|
6317 |
All |
2 Months to 59 Months (Child) |
NCT02448745 |
LiberiaDL |
|
March 1, 2014 |
June 1, 2016 |
April 1, 2017 |
May 19, 2015 |
May 1, 2018 |
|
- Bomi County Health Team
Tubmanburg, Bomi County, Liberia
|
|
7 |
NCT02344407 |
Active, not recruiting Has Results |
Partnership for Research on Ebola Vaccines in Liberia (PREVAIL) |
|
- Biological: VSVG-ZEBOV
- Biological: ChAd3-EBO Z
- Biological: Placebo
|
Interventional
|
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Serious Adverse Events.
- Immunogenicity Measures (ELISA and Neutralization Antigen-specific Assays for Antibody.
|
1500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02344407 |
999915071 15-I-N071 |
|
January 20, 2015 |
June 1, 2016 |
June 1, 2020 |
January 26, 2015 |
August 23, 2018 |
August 1, 2017 |
- Liberian Ministry of Health and Social Welfare
Monrovia, Liberia
|
|
8 |
NCT02333578 |
Unknown † |
Clinical Trial to Evaluate the Efficacy and Safety of Convalescent Plasma for Ebola Treatment |
|
- Procedure: Convalescent Plasma Treatment
|
Interventional
|
Not Applicable |
- Clinical Research Management, Inc.
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- EBOV viral load in blood of ECP Group as measured by quantitative FDA-authorized DoD EZ1 Real-time RT-PCR using USAMRIID research protocol
|
70 |
All |
18 Years and older (Adult, Older Adult) |
NCT02333578 |
EVD001 |
EVD001 |
November 2014 |
April 2015 |
June 2015 |
January 7, 2015 |
January 7, 2015 |
|
- ELWA-2 Ebola Treatment Unit
Monrovia, Liberia
|
|
9 |
NCT01905436 |
Completed |
Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia |
- Lymphatic Filariasis
- Onchocerciasis
- Soil Transmitted Helminth (STH) Infections
|
- Drug: Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
|
Observational
|
|
- Washington University School of Medicine
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Cross-Sectional
|
- Microfilaria prevalence based on results of microscopic examination of blood smears and skin snips.
- Prevalence of filarial antigenemia in blood and intensity of filarial and intestinal worm infections based on results of microscopy.
|
17066 |
All |
5 Years and older (Child, Adult, Older Adult) |
NCT01905436 |
201107185 |
DOLF-LIBERIA |
March 2012 |
April 2017 |
July 2017 |
July 23, 2013 |
May 4, 2018 |
|
- Liberian Institute of Biomedical Research
Charlesville, Margibi, Liberia
|
|
10 |
NCT01829815 |
Completed |
Impact of a Parenting Program in Liberia to Improve Parenting, Education, and Health Outcomes for Children in Liberia |
- Parenting Behavior
- Pre-academic and Developmental Skills
- Malaria Prevention
|
- Behavioral: Parents Make the Difference
|
Interventional
|
Not Applicable |
- International Rescue Committee
- Duke University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Parenting Behavior Assessment (adapted from multiple scales for this context)
- Parenting Self-Efficacy and Beliefs Assessment (adapted from other scales for this context; includes unique items developed for this context)
- Child Behavior Assessment (items adapted from the Strengths and Difficulties Questionnaire)
- (and 3 more...)
|
270 |
All |
18 Years and older (Adult, Older Adult) |
NCT01829815 |
5108 |
|
August 2012 |
March 2013 |
March 2013 |
April 11, 2013 |
January 25, 2016 |
|
- International Rescue Committee
Voinjama, Lofa County, Liberia
|
|
11 |
NCT00698321 |
Completed |
A School-Based HIV/STD Prevention Program to Reduce Risky Sexual Behaviors Among Adolescents in Liberia |
|
- Behavioral: HIV/STD prevention curriculum
- Behavioral: General health promotion curriculum
|
Interventional
|
Not Applicable |
- Pacific Institute for Research and Evaluation
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Frequency of unprotected sex
|
866 |
All |
13 Years to 15 Years (Child) |
NCT00698321 |
R21MH082666 DAHBR 9A-ASPA |
|
November 2008 |
March 2011 |
March 2011 |
June 17, 2008 |
May 20, 2013 |
|
- University of Liberia
Monrovia, Montserrado County, Liberia
|
|
12 |
NCT03719599 |
Recruiting |
Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia |
|
|
Observational
|
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- The frequency of P. falciparum parasitemia as defined by diagnostic tests and blood smears
- The frequency of parasitic infections due to organisms other than Plasmodium (such as Strongyloides stercoralis, filarial infections, or Schistosoma), as defined by detection of organism-specific antibody response using dried blood spots (DBS)
- The frequency of non-falciparum malaria parasitemia as defined by rapid diagnostic tests, blood smear, and PCR.
|
7510 |
All |
6 Months and older (Child, Adult, Older Adult) |
NCT03719599 |
999919007 19-I-N007 |
|
February 25, 2019 |
October 31, 2020 |
April 30, 2021 |
October 25, 2018 |
February 20, 2019 |
|
- Charles Henry Rennie Hospital
Kakata, Liberia - Duport Road Health Center
Paynesville City, Liberia
|
|
13 |
NCT01703936 |
Completed |
Ex-combatant Reintegration in Liberia |
- Poverty
- Social Instability
|
- Other: Agricultural and life skills training program
|
Interventional
|
Not Applicable |
- Columbia University
- United Nations
- World Bank
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Potential for Social Instability
- Economic Stability
- Preferences
- (and 4 more...)
|
1330 |
All |
18 Years and older (Adult, Older Adult) |
NCT01703936 |
AAAK6203 |
|
May 2009 |
March 2010 |
July 2011 |
October 11, 2012 |
October 11, 2012 |
|
- Tumutu Agricultural Training Program
Salala, Bong County, Liberia - Sinoe Agricultural Training Program
Panama, Sinoe County, Liberia
|
|
14 |
NCT02431923 |
Active, not recruiting |
Ebola Virus Disease Survivors: Clinical and Immunologic Follow-up |
|
|
Observational
|
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To characterize the clinical sequelae seen in convalescent Ebola virus disease (EVD) patients.
- Assess whether convalescent EVD patients can transmit infection to household and sexual contacts as determined by development of EVD or Ebola seroconversion in contacts
- Better define the immune response in EVD survivors.
|
4043 |
All |
5 Years to 65 Years (Child, Adult, Older Adult) |
NCT02431923 |
150122 15-I-0122 |
|
April 30, 2015 |
June 30, 2020 |
June 30, 2020 |
May 1, 2015 |
February 7, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - Monrovia Medical Unit ELWA-2 Hospital
Monrovia, Liberia
|
|
15 |
NCT03733093 |
Recruiting |
PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR) |
|
|
Observational
|
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Description of major social/demographic, clinical, immunologic, and virologic characteristics of HIV disease in the study population at baseline.
- Description of the course of HIV disease in the study population as awhole or by subgroup.
- Determine ARV genotypic resistance mutations within 1 year of study initiation on stored samples from a subset of participants with HIV-1 pVL >1000 copies/mL at baseline (+/- ART) or at other early study timepoints.
|
4000 |
All |
up to 99 Years (Child, Adult, Older Adult) |
NCT03733093 |
999919014 19-I-N014 |
|
February 25, 2019 |
November 30, 2023 |
November 30, 2024 |
November 7, 2018 |
February 20, 2019 |
|
- C.H. Rennie Hospital
Kakata, Liberia - John F. Kennedy (JFK) Medical Center
Monrovia, Liberia - Redemption Hospital
Monrovia, Liberia - Duport Road Clinic
Paynesville, Liberia
|
|
16 |
NCT03400930 |
Recruiting |
Biomedical Investigations for Optimized Diagnosis and Monitoring of Severe Acute Malnutrition (SAM): Elucidating the Heterogeneous Diagnosis of SAM by Current Anthropometric Criteria and Moving Beyond |
- Severe Acute Malnutrition
|
- Other: Severe Acute Malnutrition
|
Observational
|
|
- Action Contre la Faim
- Duke University
- University Ghent
- (and 4 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Leptin
- Stable Isotope Analysis (SIA)
- Clinical Signs
- (and 15 more...)
|
450 |
All |
6 Months to 5 Years (Child) |
NCT03400930 |
1061/15 |
OptiDiag |
January 1, 2017 |
March 31, 2018 |
March 31, 2018 |
January 17, 2018 |
January 17, 2018 |
|
- Action Against Hunger, Bangladesh
Cox's Bazar, Chittagong, Bangladesh - Action Contre la Faim, Burkina Faso
Fada N'Gourma, Région De l'Est, Burkina Faso - Action Against Hunger, Liberia
Monrovia, Montserrado, Liberia
|
|
17 |
NCT02818582 |
Recruiting |
GS-5734 to Assess the Antiviral Activity, Longer-Term Clearance of Ebola Virus, and Safety in Male Ebola Survivors With Evidence of Ebola Virus Persistence in Semen |
|
- Drug: GS-5734
- Other: Placebo Comparator
|
Interventional
|
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- To compare the antiviral activity over 28 days following the administration of 5 days of IV GS-5734 versus placebo in male Ebola Virus Disease survivors with evidence of Ebola virus in their semen.
- To compare the effect of 5 days of IV GS-5734 versus placebo on the detection of Ebola RNA in semen of male survivors of Ebola Virus Disease over 24 weeks.
- To evaluate the safety and tolerability of GS-5734 in male Ebola survivors with evidence of Ebola virus in their semen.
- (and 2 more...)
|
120 |
Male |
18 Years and older (Adult, Older Adult) |
NCT02818582 |
999916137 16-I-N137 |
|
June 28, 2016 |
June 1, 2019 |
June 1, 2019 |
June 29, 2016 |
January 28, 2019 |
|
- National Center for Trainingand Research in Rural Health
Conakry, Guinea - Physician at the service of the Infectious and Tropical Diseases
Conakry, Guinea - JFK Hospital
Monrovia, Liberia - Duport Road PREVAIL Clinic
Paynesville, Liberia
|
|
18 |
NCT00790998 |
Completed |
Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection |
|
- Drug: Moxidectin
- Drug: Ivermectin
|
Interventional
|
Phase 3 |
- Medicines Development Limited
- World Health Organization
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- skin microfilaria density (mf/mg)
- skin microfilaria reduction from baseline
- proportion of subjects with undetectable levels of skin microfilaria
- percent reduction in microfilaria levels in the anterior chamber of the eye
|
1497 |
All |
12 Years and older (Child, Adult, Older Adult) |
NCT00790998 |
3110A1-3000 B1751006 - ONCBL60801 |
|
April 2009 |
February 2012 |
May 2012 |
November 14, 2008 |
January 31, 2018 |
|
- Centre de Recherche Clinique de Butembo - Université Catholique du Graben
Butembo, Congo, The Democratic Republic of the - Centre de Recherche en Maladies Tropicales de l'Ituri
Rethy, Congo, The Democratic Republic of the - Onchocerciasis Chemotherapy Research Center
Hohoe, Ghana - Liberian Institute for Biomedical Research Clinical Research Center
Bolahun, Lofa County, Liberia
|
|
19 |
NCT02363322 |
Suspended |
Putative Investigational Therapeutics in the Treatment of Patients With Known Ebola Infection |
|
- Drug: ZMApp
- Other: Treatment A
|
Interventional
|
Phase 1 Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- The Ministry of Health and Social Welfare of the Republic of Liberia
- The Ministry of Health and Sanitation of the Republic of Sierra Leone
- (and 3 more...)
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mortality
- Clinical and virology effects of experimental treatment
- Adverse Events
- Plasma Viral Load
|
72 |
All |
Child, Adult, Older Adult |
NCT02363322 |
150083 15-I-0083 |
|
February 13, 2015 |
December 31, 2017 |
January 1, 2021 |
February 16, 2015 |
June 27, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - CTE Forecariah
Forecariah, Guinea - Monrovia Medical Unit
Monrovia, Liberia - (and 8 more...)
|
|
20 |
NCT02876328 |
Recruiting |
Partnership for Research on Ebola VACcinations |
|
- Biological: Ad26.ZEBOV
- Biological: MVA-BN-Filo
- Biological: rVSVΔG-ZEBOV-GP
- (and 2 more...)
|
Interventional
|
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- The Liberia-US Clinical Trials Partnership Program, Partnership for Research on Ebola Virus in Liberia Project (PREVAIL)
- Institut National de la Santé Et de la Recherche Médicale, France
- London School of Hygiene and Tropical Medicine
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Number of participants with Ebola virus glycoprotein (GP-EBOV) antibody response
- Frequency of serious adverse events (SAEs)
|
4500 |
All |
1 Year and older (Child, Adult, Older Adult) |
NCT02876328 |
C15-33 PREVACEBL3005 |
PREVAC |
March 31, 2017 |
March 2019 |
March 2019 |
August 23, 2016 |
October 24, 2018 |
|
- Centre national de formation et de recherche en santé rurale (Maferyniah)
Conakry, Guinea - Landreah
Conakry, Guinea - The Redemption Hospital
Monrovia, Liberia - (and 3 more...)
|
|