| 1 |
NCT03278431 |
Completed |
Triple Combinations Against Hookworm Infections in Lao |
|
- Drug: Albendazole
- Drug: Pyrantel Pamoate
- Drug: Oxantel Pamoate
- Drug: Mebendazole
|
Interventional
|
Phase 4 |
- Swiss Tropical & Public Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Cure rates of three drug combinations
- Cure rates against hookworm of the two triple combinations
- Egg reduction rates (ERR) against hookworm and ERRs/CRs against A. lumbricoides and T. trichiura
- Incidence of adverse events 3 and 24 hours after treatment
|
420 |
All |
6 Years to 15 Years (Child) |
NCT03278431 |
TRICOMBI01032017 |
Tricombi |
September 27, 2017 |
November 17, 2017 |
December 1, 2017 |
September 11, 2017 |
May 8, 2018 |
|
- Nambak District Hospital
Luang Prabang, Lao People's Democratic Republic
|
|
| 2 |
NCT02802813 |
Completed |
P.Vivax Treatment Trial |
|
- Drug: Dihydroartemisinin-piperaquine (DP) + Primaquine (PQ)
- Drug: Dihydroartemisinin-piperaquine (DP) + Primaquine (PQ) placebo
|
Interventional
|
Phase 1
Phase 2 |
- University of Oxford
- Mahidol Oxford Tropical Medicine Research Unit
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- The incidence rate of P. vivax parasitaemia in G6PD-normal participants
- Time to P. vivax clearance
- The frequency of recurrent vivax infections (clinical and sub-clinical)
- (and 7 more...)
|
41 |
All |
10 Years and older (Child, Adult, Older Adult) |
NCT02802813 |
LOMWRU1601 |
Lao Pv |
June 14, 2016 |
June 15, 2018 |
June 15, 2018 |
June 16, 2016 |
September 20, 2018 |
|
- Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
Vientiane, Lao People's Democratic Republic
|
|
| 3 |
NCT02428647 |
Completed |
Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation |
|
- Dietary Supplement: MNP
- Dietary Supplement: preventive zinc supplement
- Dietary Supplement: therapeutic zinc supplement
- (and 3 more...)
|
Interventional
|
Not Applicable |
- University of California, Davis
- National Institute of Public Health, Lao PDR
- USDA, Western Human Nutrition Research Center
- (and 4 more...)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in length and length-for-age Z-score
- Change in weight and weight-for-age Z-score
- Incidence of diarrhea
- (and 11 more...)
|
3433 |
All |
6 Months to 23 Months (Child) |
NCT02428647 |
626187
10-1347-UCALIF-07 |
|
September 2015 |
May 2017 |
July 2017 |
April 29, 2015 |
July 13, 2018 |
|
- National Institute of Public Health
Vientiane, Lao People's Democratic Republic
|
|
| 4 |
NCT00938379 |
Unknown † |
Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR |
- Malaria
- Dengue
- Japanese Encephalitis
|
- Drug: 20% deet insect repellent
- Drug: placebo control
|
Interventional
|
Phase 3 |
- London School of Hygiene and Tropical Medicine
- Population Services International
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- reduction in malaria incidence
- Reduction in Japanese Encephalitis and / or Dengue infections
|
5000 |
All |
5 Years to 70 Years (Child, Adult, Older Adult) |
NCT00938379 |
NHLAO1 |
|
July 2009 |
December 2010 |
June 2011 |
July 13, 2009 |
July 14, 2009 |
|
- Rural villages in Attepu and Sekong Provinces, Laos PDR
Pakse, Attepu, Lao People's Democratic Republic
|
|
| 5 |
NCT03241316 |
Recruiting |
Antibiotics and Activity Spaces: An Exploratory Study of Behaviour, Marginalisation, and Knowledge Diffusion |
- Antibiotic Use
- Rural Healthcare-seeking Behaviour
- Marginalisation (Economic, Social, Spatial)
|
- Behavioral: Observational study of behaviour
|
Observational
|
|
- University of Oxford
- Mahidol Oxford Tropical Medicine Research Unit
- Economic and Social Research Council, United Kingdom
- Mae Fah Luang University
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Other
|
- General population and villagelevel data on antibiotic access and use within individuals' healthcare-seeking pathways
- Indicators of economic, social, and spatial marginalisation
- Access to formal and informal medical treatment
- (and 7 more...)
|
4800 |
All |
18 Years and older (Adult, Older Adult) |
NCT03241316 |
BACN001 |
ESRC |
November 15, 2017 |
April 30, 2018 |
October 31, 2018 |
August 7, 2017 |
November 24, 2017 |
|
- Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
Vientiane, Lao People's Democratic Republic - Chiangrai Clinical research Unit
Chiang Rai, Chiangrai, Thailand
|
|
| 6 |
NCT03527732 |
Not yet recruiting |
Efficacy and Safety of IVM/ALB Co-administration |
|
- Drug: Albendazole
- Drug: Albendazole and Ivermectin
|
Interventional
|
Phase 2
Phase 3 |
- Jennifer Keiser
- Côte d'Ivoire: Centre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS)
- Lao PDR: National Institute of Public Health (NIOPH)
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cure rate against T. trichiura
- Egg-reduction rate (ERR) against T. trichiura
- Cure rates (CRs) against concomitant soil-transmitted helminth infections.
- (and 6 more...)
|
1960 |
All |
6 Years to 60 Years (Child, Adult) |
NCT03527732 |
1 |
|
September 2018 |
August 2019 |
August 2019 |
May 17, 2018 |
August 13, 2018 |
|
- Centre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS)
Abidjan, Côte D'Ivoire - Lao Tropical and Public Health Institute
Sisattanak, Lao People's Democratic Republic - Public Health Laboratory Ivo de Carneri, P.O. Box 122
Chake Chake, Pemba, Tanzania
|
|
| 7 |
NCT03465488 |
Recruiting |
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance |
- Soil-transmitted Helminth Infections
|
- Drug: Albendazole Pill 400mg (GSK)
|
Interventional
|
Not Applicable |
- University Ghent
- Swiss Tropical & Public Health Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Validation of the performance of FECPAKG2 to assess drug efficacy
- In depth evaluation of the FECPAKG2 technique to assess drug efficacy
- Validation of b-tubulin gene as a molecular marker for benzimidazole resistance
- (and 2 more...)
|
1000 |
All |
5 Years to 18 Years (Child, Adult) |
NCT03465488 |
OPP1120972 |
StarwormsWP1 |
August 15, 2016 |
May 2018 |
May 2018 |
March 14, 2018 |
March 14, 2018 |
|
- Fiocruz - Research institute of Renê Rachou
Belo Horizonte, Minas Gerais, Brazil - Jimma University
Jimma, Ethiopia - National Institute of Public Health
Vientiane, Lao People's Democratic Republic - The Public Health Laboratory - Ivo de Carneri (PHL-IdC)
Chake Chake, Pemba, Tanzania
|
|
| 8 |
NCT03384498 |
Recruiting |
Malaria Genetic Surveillance |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Annual maps and reports on the prevalence of drug resistance-linked genetic mutations in P. falciparum parasites in the Greater Mekong Subregion
- Allelic variations associated to drug resistance in P. falciparum at the locations surveyed
- Allelic variations associated to drug resistance in P. vivax at the locations surveyed
- (and 4 more...)
|
30000 |
All |
Child, Adult, Older Adult |
NCT03384498 |
BIOINF1602 |
|
October 2016 |
October 2019 |
December 2020 |
December 27, 2017 |
December 27, 2017 |
|
- National Centre for Malaria Control, Parasitology and Entomology (CNM)
Phnom Penh, Cambodia - Center of Malariology, Parasitology and Entomology
Sisattanak District, Vientiane, Lao People's Democratic Republic - Buntharik hospital
Ubon Ratchathani, Thailand - (and 2 more...)
|
|
| 9 |
NCT01872702 |
Completed |
Targeted Chemo-elimination (TCE) of Malaria |
- Plasmodium Falciparum Malaria
|
- Drug: malaria elimination using DP and low-dose primaquine
|
Interventional
|
Not Applicable |
- University of Oxford
- Mahidol Oxford Tropical Medicine Research Unit
- National Centre for Parasitology, Entomology and Malaria Control, Cambodia
- (and 7 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- prevalence of falciparum malaria measured by qPCR (quantitative real time polymerase chain reaction), 12 months after the first administration of treatment with dihydroartemisinin-piperaquine and primaquine. (1017-13 and 23-15)
- prevalence of falciparum malaria measured by qPCR (quantitative real time polymerase chain reaction), 12 months after the first administration of targeted malaria elimination (1015-13)
- prevalence of falciparum malaria measured by qPCR (quantitative real time polymerase chain reaction), 4 months after the first administration of target malaria-elimination (23-15)
- Safety and acceptability of targeted malaria elimination (1017-13 and 1015-13)
|
8000 |
All |
6 Months and older (Child, Adult, Older Adult) |
NCT01872702 |
BAKMAL1305 |
TME |
April 2013 |
July 2017 |
July 2017 |
June 7, 2013 |
August 10, 2017 |
|
- Pailin
Pailin, Cambodia - Savannakhet
Savannakhet, Lao People's Democratic Republic - Mahidol Oxford Clincal Research Unit, Myanmar
Rangoon, Myanmar - (and 2 more...)
|
|
| 10 |
NCT03343431 |
Recruiting |
Antiviral Prophylaxis and Infant Vaccination to Prevent Perinatal Hepatitis B Infection |
|
- Drug: Anti-HBV antiviral prophylaxis
|
Interventional
|
Phase 3 |
- Institut de Recherche pour le Developpement
- Chiang Mai University
- Ministry of Health, Thailand
- Ministry of Health, Lao PDR
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Infant hepatitis B infection status
- Maternal HBV DNA changes
- Infant levels of anti-HBs antibodies
- (and 5 more...)
|
499 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03343431 |
iTAP-2 |
|
August 2, 2018 |
December 31, 2021 |
December 31, 2023 |
November 17, 2017 |
August 17, 2018 |
|
- Mahosot Hospital
Vientiane, Lao People's Democratic Republic - Mother and Newborn Hospital
Vientiane, Lao People's Democratic Republic - Setthathirath Hospital
Vientiane, Lao People's Democratic Republic - (and 29 more...)
|
|
| 11 |
NCT02128139 |
Unknown † |
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study |
|
|
Observational
|
|
- Institut National de la Santé Et de la Recherche Médicale, France
- Ministry of Health, Mozambique
- War Memorial Hospital
- (and 2 more...)
|
Other / U.S. Fed |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Mortality at 1 month follow-up
- Mortality at 6 months follow-up
|
500 |
All |
1 Year and older (Child, Adult, Older Adult) |
NCT02128139 |
EndoDev
Cardiology and Development |
EndoDev |
June 2014 |
June 2015 |
June 2015 |
May 1, 2014 |
May 1, 2014 |
|
- Joseph Kado
Suva, Fiji - Paul N. Newton
Vientiane, Lao People's Democratic Republic - Beatriz Ferreira
Maputo, Mozambique - (and 3 more...)
|
|
| 12 |
NCT02453308 |
Completed |
A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC) |
|
|
Interventional
|
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- PCR corrected efficacy defined as adequate clinical and parasitological response (ACPR)
- Parasite clearance half-life
- Parasite reduction rates and ratios at 24 and 48 hours assessed by microscopy
- (and 21 more...)
|
1110 |
All |
6 Months to 65 Years (Child, Adult, Older Adult) |
NCT02453308 |
BAKMAL1502 |
TRACII |
August 2015 |
March 2018 |
March 2018 |
May 25, 2015 |
May 9, 2018 |
|
- College of Medicine Chittagong
Ramu, Bangladesh - Pailin
Pailin, Cambodia - Preah Vihear
Preah Vihear, Cambodia - (and 17 more...)
|
|
| 13 |
NCT01350856 |
Completed |
Tracking Resistance to Artemisinin (TRAC) |
|
- Drug: Artesunate 2
- Drug: Artesunate 4
|
Interventional
|
Phase 4 |
- University of Oxford
- Mahidol University
- Worldwide Antimalarial Resistance Network
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Parasite clearance rate
- Parasite clearance time
- Parasite reduction rates and ratios
- (and 10 more...)
|
1700 |
All |
6 Months to 65 Years (Child, Adult, Older Adult) |
NCT01350856 |
BAKMAL1101 |
TRAC |
May 2011 |
April 2014 |
December 2014 |
May 10, 2011 |
June 1, 2015 |
|
- Ramu Upazila Health Complex
Cox's Bazaar, Bangladesh - Pailin General Hospital
Pailin, Cambodia - District Referral Hospital
Preah Vihear, Cambodia - (and 16 more...)
|
|
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