259 studies found for:    "Diffuse scleroderma"
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Study Details
Participant Details
Identifiers
Dates
Rank Status Study
1 Recruiting Safety, Tolerability and Pharmacokinetic Study of MRG-201 in Healthy Volunteers and Patients With Cutaneous Scleroderma
Conditions: Limited Scleroderma;   Localized Scleroderma;   Diffuse Scleroderma
Interventions: Drug: MRG-201;   Drug: Placebo
2 Completed A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma
Conditions: Limited Scleroderma;   Diffuse Scleroderma
Intervention:
3 Recruiting IVIG Treatment in Systemic Sclerosis
Conditions: Systemic Sclerosis;   Diffuse Scleroderma
Intervention: Biological: Privigen
4 Recruiting IL1-TRAP, Rilonacept, in Systemic Sclerosis
Conditions: Scleroderma;   Systemic Sclerosis;   Diffuse Scleroderma;   Diffuse Systemic Sclerosis
Interventions: Drug: Rilonacept;   Drug: Placebo
5 Not yet recruiting Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
Conditions: Scleroderma, Diffuse;   Scleroderma, Systemic;   Scleroderma, Limited;   Sclerosis, Progressive Systemic;   Skin Diseases;   Connective Tissue Diseases;   Pathologic Processes;   Autoimmune Diseases
Interventions: Drug: Oral Ifetroban;   Drug: Oral Placebo
6 Completed Psychological Treatments for Scleroderma
Conditions: Pain;   Depression;   Scleroderma;   Systemic Sclerosis
Interventions: Behavioral: Cognitive behavioral therapy;   Behavioral: Disease/health education;   Behavioral: Self-help cognitive behavioral intervention facilitated by a psychologist
7 Completed
Has Results
Scleroderma Lung Disease
Conditions: Lung Diseases;   Pulmonary Fibrosis;   Systemic Scleroderma;   Scleroderma, Systemic
Interventions: Drug: Cyclophosphamide;   Drug: Placebo
8 Completed
Has Results
Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine
Conditions: Systemic Sclerosis;   Scleroderma
Interventions: Drug: treprostinil diethanolamine;   Drug: placebo
9 Active, not recruiting Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
Conditions: Systemic Sclerosis;   Scleroderma;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension
Intervention:
10 Recruiting Gastroesophageal Reflux Treatment in Scleroderma
Conditions: Gastroesophageal Reflux Disease;   Systemic Sclerosis;   Scleroderma
Interventions: Drug: Alginic acid;   Drug: placebo (for domperidone);   Drug: Domperidone;   Drug: placebo (of alginic acid)
11 Terminated Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients
Conditions: Scleroderma;   Systemic Sclerosis
Interventions: Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Thymoglobulin;   Procedure: Leukapheresis;   Procedure: Self bone marrow transplant
12 Completed Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Scleroderma Patients
Conditions: Systemic Sclerosis;   Scleroderma
Intervention: Drug: Bosentan
13 Terminated Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse Scleroderma
Condition: Scleroderma
Interventions: Drug: Imatinib mesylate;   Other: Placebo
14 Completed Recombinant Human Relaxin in the Treatment of Diffuse Scleroderma
Condition: Systemic Sclerosis
Intervention: Drug: Relaxin
15 Completed Efficacy and Safety of Imatinib in Scleroderma
Conditions: Scleroderma, Localized;   Scleroderma, Systemic
Intervention: Drug: imatinib mesylate
16 Recruiting Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis
Conditions: Scleroderma, Diffuse;   Diffuse Cutaneous Systemic Sclerosis
Interventions: Drug: IVA337;   Drug: Placebo
17 Recruiting Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease
Conditions: Systemic Sclerosis;   Scleroderma;   Interstitial Lung Disease;   Lung Fibrosis
Interventions: Drug: Cyclophosphamide;   Drug: Placebo
18 Recruiting Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning for Patients With Severe Systemic Sclerosis
Conditions: Systemic Scleroderma;   Severe Systemic Sclerosis
Interventions: Drug: fludarabine phosphate;   Drug: Mycophenolic Acid;   Drug: tacrolimus;   Radiation: total-body irradiation;   Procedure: bone marrow transplantation;   Procedure: reduced intensity allogeneic hematopoietic stem cell transplantation;   Procedure: quality-of-life assessment;   Other: laboratory biomarker analysis;   Other: flow cytometry;   Procedure: biopsy;   Drug: cyclophosphamide
19 Unknown  Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
Conditions: Scleroderma, Systemic;   Scleroderma, Diffuse;   Scleroderma, Limited;   Raynaud Phenomenon
Interventions: Drug: Sildenafil citrate;   Drug: Placebo
20 Recruiting Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma
Condition: Scleroderma
Interventions: Drug: atorvastatin;   Drug: Placebo

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Indicates status has not been verified in more than two years