| 1 |
NCT03639038 |
Not yet recruiting |
Tuberculosis Diagnosis by Flow Cytometry |
|
|
Observational
|
|
- University of Alabama at Birmingham
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- ATB assay for differentiation of latent and active TB infection using Blood samples
- DTB assay for rapid detection and drug sensitivity testing of Mtb using sputum specimens
|
380 |
All |
5 Years to 100 Years (Child, Adult, Older Adult) |
NCT03639038 |
IRB-300001699 |
|
September 30, 2018 |
April 1, 2019 |
July 1, 2019 |
August 20, 2018 |
September 5, 2018 |
|
- Center for Infectious Disease Research in Zambia (CIDRZ)
Lusaka, Zambia
|
|
| 2 |
NCT03523182 |
Completed |
Spirulina Supplementation and Infant Growth, Morbidity and Motor Development |
- Stunting
- Underweight
- Pneumonia, Pneumocystis
- (and 4 more...)
|
- Dietary Supplement: Spirulina
- Dietary Supplement: Control
|
Interventional
|
Not Applicable |
- Programme Against Malnutrition
- Hitotsubashi University
- Alliance Forum Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from baseline in height-for-age z-scores (HAZ) at endline (12 months)
- Change from baseline in weight-for-age z-scores (WAZ) at endline (12 months)
- Change from baseline in pneumonia incidence at endline (12 months)
- (and 4 more...)
|
501 |
All |
6 Months to 18 Months (Child) |
NCT03523182 |
FWA00000338 |
|
March 1, 2015 |
April 30, 2016 |
April 30, 2016 |
May 14, 2018 |
May 14, 2018 |
|
- Programme Against Malnutrition
Mansa, Luapura, Zambia
|
|
| 3 |
NCT03497195 |
Recruiting |
Achieving Tuberculosis (TB) Control In Zambia |
|
- Diagnostic Test: Screening at community level
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- increase TB case detection
|
26000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03497195 |
IRB-300001132 |
TB |
July 1, 2018 |
May 1, 2020 |
May 1, 2021 |
April 13, 2018 |
August 16, 2018 |
|
- Center for Infectious Disease Research in Zambia (CIDRZ)
Lusaka, Zambia
|
|
| 4 |
NCT03373669 |
Recruiting |
Effect of Extended Dose Intervals on the Immune Response to Oral Cholera Vaccine |
- Cholera
- Vibrio Cholerae Infection
|
- Biological: Oral Cholera Vaccine
- Biological: Adjusted Dose Oral Cholera Vaccine
|
Interventional
|
Phase 4 |
- Johns Hopkins Bloomberg School of Public Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in Vibriocidal GMT
- Vibriocidal Antibody Response Rates
- Age specific vibriocidal response
- (and 2 more...)
|
120 |
All |
1 Year and older (Child, Adult, Older Adult) |
NCT03373669 |
IRB00008066 |
|
November 16, 2017 |
August 16, 2018 |
December 1, 2018 |
December 14, 2017 |
December 18, 2017 |
|
- Center for Infectious Disease Research - Zambia
Lusaka, Zambia
|
|
| 5 |
NCT03186768 |
Completed |
Soap on a Rope Trial |
|
- Behavioral: Soap on a rope hall pass intervention
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Other
|
- Change in hand washing behavior
|
50 |
All |
Child, Adult, Older Adult |
NCT03186768 |
SoapRopetrial |
|
June 12, 2017 |
September 30, 2017 |
December 31, 2017 |
June 14, 2017 |
May 17, 2018 |
|
- Namwala District
Namwala, Zambia
|
|
| 6 |
NCT03174015 |
Active, not recruiting |
Sanitation Demand Creation in Peri-Urban Slums of Lusaka, Zambia |
|
- Behavioral: Bauleni Secret
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- Centre for Infectious Disease Research in Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Having a hole-cover or water-sealed pan
- Having a latrine door that locks from the inside
- Having a latrine door that locks from the outside
- (and 7 more...)
|
1072 |
All |
18 Years and older (Adult, Older Adult) |
NCT03174015 |
QA_840 |
SanDem |
August 7, 2017 |
January 2018 |
January 2018 |
June 2, 2017 |
December 8, 2017 |
|
- Bauleni Compound
Lusaka, Zambia
|
|
| 7 |
NCT03158844 |
Completed |
HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia |
|
|
Observational
|
|
- University of Alabama at Birmingham
- University Teaching Hospital
- Centre for Infectious Disease Research in Zambia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Undetectable HIV viral load at 90 days post-discharge
- Proportion of HIV-infected inpatients who are on ART upon admission
- Mortality rate
- ART initiation
|
250 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03158844 |
F160812007 |
COLAH |
May 16, 2017 |
February 28, 2018 |
May 31, 2018 |
May 18, 2017 |
August 10, 2018 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 8 |
NCT03158818 |
Active, not recruiting |
Chronic Hepatitis B Virus Infection in Zambia |
- HBV
- Fibrosis, Liver
- Cirrhosis, Liver
- (and 3 more...)
|
|
Observational
|
|
- University of Alabama at Birmingham
- Tropical Gastroenterology and Nutrition Group
- Centre for Infectious Disease Research in Zambia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in the percentage of patients with HBV viral suppression (Effectiveness of antiviral therapy in HBV-infected patients)
- Proportion of chronic HBV-infected patients with an indication for antiviral treatment.
- HBV viral control among patients on antiviral treatment
- (and 3 more...)
|
500 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03158818 |
F151224005 |
HUTCH |
August 23, 2016 |
January 2021 |
January 2021 |
May 18, 2017 |
August 28, 2018 |
|
- Tropical Gastroenterology and Nutrition Group
Lusaka, Zambia
|
|
| 9 |
NCT03149627 |
Recruiting |
Chronic Hepatitis B Virus Clinical Epidemiology in a Representative Sample of Zambian Adults |
- HBV
- Alcoholic Hepatitis
- Liver Fibroses
|
- Other: Estimates - prevalence of lifetime/chronic HBV infection
|
Observational
|
|
- University of Alabama at Birmingham
- University Teaching Hospital
- Tropical Gastroenterology and Nutrition Group
- (and 2 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Prevalence and correlates of lifetime HBV infection
- Proportion of Zambian adults who require antiviral therapy for chronic HBV infection
- Clinical phenotypes of patients with chronic HBV infection
- (and 5 more...)
|
6000 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03149627 |
X160524001 |
HEP-ZED |
June 7, 2017 |
November 2018 |
November 30, 2018 |
May 11, 2017 |
October 3, 2018 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 10 |
NCT03141736 |
Not yet recruiting |
Kangaroo Mother Care With Plastic Bag (Trials 1A & 1B) |
- Preterm Birth
- Hypothermia, Newborn
|
- Other: KMC & WHO protocol (0-1 hour)
- Other: KMC, WHO protocol & bag (0-1 hour)
- Other: KMC & WHO protocol (1-24 hours)
- Other: KMC, WHO protocol & bag (1-24 hours)
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- University Teaching Hospital, Lusaka, Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Moderate or severe hypothermia at 1 hour after birth (Phase 1A)
- Moderate or severe hypothermia at 24 hours or discharge (Phase 1B)
- Any hypothermia at 1 hour after birth (Phase 1A)
- (and 11 more...)
|
420 |
All |
up to 2 Hours (Child) |
NCT03141736 |
F150807004 |
|
August 19, 2019 |
October 12, 2019 |
October 12, 2019 |
May 5, 2017 |
August 21, 2018 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 11 |
NCT03141723 |
Completed |
Kangaroo Mother Care With Plastic Bag (Trials 2A & 2B) |
- Preterm Infant
- Hypothermia Neonatal
|
- Other: KMC & WHO protocol (0-1 hour)
- Other: KMC, WHO protocol & bag (0-1 hour)
- Other: KMC & WHO protocol (1-24 hours)
- Other: KMC, WHO protocol & bag (1-24 hours)
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- University Teaching Hospital, Lusaka, Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Moderate or severe hypothermia at 1 hour after birth (Phase 2A)
- Moderate or severe hypothermia at 24 hours or discharge (Phase 2B)
- Any hypothermia at 1 hour after birth (Phase 2A)
- (and 11 more...)
|
423 |
All |
up to 24 Hours (Child) |
NCT03141723 |
F150807003 |
|
May 19, 2017 |
August 12, 2017 |
August 12, 2017 |
May 5, 2017 |
June 18, 2018 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 12 |
NCT03134924 |
Completed |
Vaginal Practices in Human Immunodeficiency Virus (HIV) Positive Women in Zambia, a Bio-Behavioral Intervention "WASH-2" |
|
- Behavioral: Women's and Sexual Health [WASH]
- Behavioral: Enhanced Standard of Care
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
128 |
Female |
18 Years to 60 Years (Adult) |
NCT03134924 |
20120418 |
|
May 3, 2013 |
February 5, 2014 |
February 5, 2014 |
May 1, 2017 |
May 1, 2017 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 13 |
NCT02994329 |
Completed |
Community-based Distribution of Oral HIV Self-testing Kits |
|
- Device: OraQuick® HIV Self-Test (Orasure Technologies, Thailand)
|
Interventional
|
Not Applicable |
- Zambart
- London School of Hygiene and Tropical Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The proportion of the total resident adult population who know their HIV status
- Proportion of total resident adult population who consent to participate in the intervention
- Proportion of male resident adult population who consent to participate in the intervention
- (and 9 more...)
|
8080 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT02994329 |
HIV-SELF 3IE |
|
January 18, 2017 |
September 30, 2017 |
September 30, 2017 |
December 15, 2016 |
January 16, 2018 |
|
|
|
| 14 |
NCT02970552 |
Active, not recruiting |
Feasibility of Vaginal Progesterone to Reduce HIV-Associated Preterm Birth |
|
- Drug: Vaginal Progesterone
- Drug: Placebo
|
Interventional
|
Phase 4 |
- University of North Carolina, Chapel Hill
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Proportion of women with adequate adherence
- Acceptability of use of VP
- Preliminary efficacy
|
140 |
Female |
18 Years and older (Adult, Older Adult) |
NCT02970552 |
16-2174
1R21HD090987-01 |
VP |
July 1, 2017 |
November 15, 2018 |
December 31, 2018 |
November 22, 2016 |
August 29, 2018 |
|
- Kamwala District Health Centre
Lusaka, Zambia
|
|
| 15 |
NCT02946762 |
Recruiting |
TasP in Correctional Facilities |
|
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Department for International Development, United Kingdom
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of inmates with HIV-infection who were assessed for and offered ART initiation under TasP/UTT
- Proportion of all HIV-infected inmates starting ART who are retained on ART among those who remain in the study facility
- Proportion of inmates on ART with an HIV RNA <40 c/mL at 6 months of ART
- (and 2 more...)
|
6000 |
All |
18 Years and older (Adult, Older Adult) |
NCT02946762 |
15-1473 |
|
February 1, 2016 |
April 30, 2018 |
December 2018 |
October 27, 2016 |
October 12, 2018 |
|
- Lusaka Central Corrections ART Clinic
Lusaka, Zambia
|
|
| 16 |
NCT02941159 |
Recruiting |
SF2000SD Clinical Trial in Zambia |
|
- Biological: SF2000SD
- Biological: Placebo
|
Interventional
|
Phase 1 |
- Tropical Diseases Research Centre, Zambia
- National Institute for Scientific and Industrial Research
- University of Zambia
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Proportion of study participants with clinical adverse events such as diarrhea, vomiting, changes in vital signs etc. associated with the test product
- Proportion of study participants with changes in laboratory liver and renal values after administration of test product. These will include ALT, AST, ALP, Total biluribin, Glucose, Urea and Creatinine
- Proportion of study participants with changes in blood hematological values after administration of test product. This will involve Full Blood Count (FBC) including differential for white blood cells
|
43 |
Male |
18 Years to 45 Years (Adult) |
NCT02941159 |
SF2000SDPh1 |
SF2000SD |
September 2016 |
November 2017 |
February 2018 |
October 21, 2016 |
November 17, 2017 |
|
- Tropical Diseases Resaerch Centre
Ndola, Copperbelt, Zambia
|
|
| 17 |
NCT02905162 |
Recruiting |
Understanding Longitudinal Clinical Outcomes and Post-release Retention in Care Among HIV-infected Prisoners in Lusaka, Zambia |
|
- Other: Transitional HIV care for prison releasees
|
Observational
|
|
- University of North Carolina, Chapel Hill
- National Institutes of Health (NIH)
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of prison releasees retained in care
- Number virologically suppressed
- Change in CD4 count
|
552 |
All |
18 Years and older (Adult, Older Adult) |
NCT02905162 |
16-0276
1K01TW010272-01 |
|
March 16, 2017 |
December 2018 |
December 2018 |
September 19, 2016 |
October 12, 2018 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 18 |
NCT02866097 |
Unknown † |
Integrated Community Case Management Study in Eastern Province, Zambia |
|
- Other: mHealth inventory management
- Other: Supportive supervision
- Other: ICCM current standard of care
|
Interventional
|
Not Applicable |
- Zambia Center for Applied Health Research and Development
- UNICEF
- Bill and Melinda Gates Foundation
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Composite percentage of children appropriately treated for malaria, diarrhea, and pneumonia.
- a) Medicine availability (artemether-lumefantrine)
- b) Clinical supervision coverage
- (and 6 more...)
|
3840 |
All |
1 Month to 5 Years (Child) |
NCT02866097 |
4980/A0/04/001/010 |
|
March 2016 |
August 2016 |
September 2016 |
August 15, 2016 |
August 15, 2016 |
|
- Chadiza and Chipata Districts
Chipata, Eastern Province, Zambia
|
|
| 19 |
NCT02804490 |
Completed |
Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status |
|
- Dietary Supplement: Conventional white maize
- Dietary Supplement: Provitamin A carotenoid biofortified maize
- Dietary Supplement: Preformed vitamin A fortified maize
|
Interventional
|
Phase 3 |
- Johns Hopkins Bloomberg School of Public Health
- University of California, Davis
- Newcastle University
- HarvestPlus
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Infant vitamin A stores
- Maternal breast milk retinol
- Maternal plasma retinol
- Maternal dark adaptation
|
255 |
Female |
18 Years to 45 Years (Adult) |
NCT02804490 |
2014H8314.JHU |
|
March 2016 |
June 2, 2017 |
June 2, 2017 |
June 17, 2016 |
August 21, 2017 |
|
- JHU Office
Mkushi, Central Province, Zambia
|
|
| 20 |
NCT02793804 |
Completed |
HIV Self-Testing Africa Zambia |
|
- Device: Oraquick (made in Thailand)
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- Zambart
- Society for Family Health, Zambia
- (and 5 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Comparison between randomisation arms in coverage of recent (within the last 12 months) HIV testing among older adolescents and adults (aged from 16 years) in the clinic catchment areas 12 months after the start of the intervention - by self-report
- Comparison between randomisation arms of antiretroviral therapy (ART) initiation rates for older adolescent and adult (aged from 16 years) cluster residents, during months 1 to 12 of the intervention - measured using clinic data
|
5005 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT02793804 |
10660 |
STAR Zambia |
June 2016 |
February 1, 2018 |
February 1, 2018 |
June 8, 2016 |
May 14, 2018 |
|
|
|
| 21 |
NCT02790827 |
Active, not recruiting |
Trial of a Multi-pronged Intervention to Address Prevention of Violence in Zambia |
- Domestic Violence
- Mental Health Impairment
- Child Abuse
- Alcoholism
|
- Behavioral: CETA
- Behavioral: Treatment as usual
|
Interventional
|
Not Applicable |
- Johns Hopkins Bloomberg School of Public Health
- SHARPZ (Serenity Harm Reduction Programme Zambia)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in violence against women as measured by Severity of Violence Against Women Scale (SVAWS)
- Change in alcohol abuse as measured by the Alcohol Use Disorders Identification Test (AUDIT)
- Change in child abuse as measured by the Youth Victimization Scale
- (and 9 more...)
|
626 |
All |
8 Years and older (Child, Adult, Older Adult) |
NCT02790827 |
IRB00006534 |
|
May 2016 |
December 2018 |
December 2018 |
June 6, 2016 |
January 26, 2018 |
|
- Serenity Harm Reduction Programme Zambia (SHARPZ)
Lusaka, Zambia
|
|
| 22 |
NCT02776254 |
Unknown † |
Differentiated Care for Improved Health Systems Efficiency and Health Outcomes in Zambia |
|
- Other: START
- Other: CAG
- Other: UAG
- Other: FAST-TRACK
|
Interventional
|
Not Applicable |
- Centre for Infectious Disease Research in Zambia
- Johns Hopkins University
- University of Alabama at Birmingham
- (and 5 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Retention in care (Time to first missed pharmacy pick-up)
- Feasibility of implementing differentiated care from stakeholder perspectives
- Feasibility of implementing differentiated care based on ART availability
- (and 13 more...)
|
3600 |
All |
15 Years and older (Child, Adult, Older Adult) |
NCT02776254 |
ID OPP1105306 |
CommART |
March 2016 |
July 2017 |
July 2017 |
May 18, 2016 |
June 20, 2016 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 23 |
NCT02729532 |
Active, not recruiting |
Effect of Xpert MTB/RIF on Patient Outcomes |
|
|
Observational
|
|
- University of North Carolina, Chapel Hill
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Culture-positive patient drop-out before accessing treatment
- Time to TB treatment
- Percentage of participants who receive TB treatment within 14 days of enrolment (effect of Xpert on the accuracy of TB diagnosis)
- (and 3 more...)
|
892 |
All |
18 Years and older (Adult, Older Adult) |
NCT02729532 |
14-1697
US NIH Grant P30 AI50410-17 |
|
June 22, 2016 |
February 28, 2018 |
December 2018 |
April 6, 2016 |
March 12, 2018 |
|
- Chelstone and Chilenje Health Centres
Lusaka, Zambia
|
|
| 24 |
NCT02709967 |
Active, not recruiting |
Research Initiative to Support the Empowerment of Girls |
|
- Other: Material support
- Other: Economic
- Behavioral: Community dialogue
|
Interventional
|
Not Applicable |
- University of Bergen
- University of Zambia
- Chr. Michelsens Institutt
- Norwegian School of Economics
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of births within 8 months of the end of the intervention
- Incidence of births before girls' 18th birthday
- Proportion of girls who sit for grade 9 exam
- (and 21 more...)
|
5000 |
Female |
9 Years to 25 Years (Child, Adult) |
NCT02709967 |
2015/895 |
RISE |
March 2016 |
December 2020 |
December 2020 |
March 16, 2016 |
November 28, 2016 |
|
- University of Zambia
Lusaka, Zambia
|
|
| 25 |
NCT02700269 |
Recruiting |
Vanderbilt-Zambia Innovations in Global Health Technologies |
|
|
Observational
|
|
- Macha Research Trust, Zambia
- Vanderbilt University
- National Institutes of Health (NIH)
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Enhancement of malaria RDT to detect low levels of P falciparum parasites
|
200 |
All |
6 Months to 85 Years (Child, Adult, Older Adult) |
NCT02700269 |
MRT15003.2
5D43TW009348 |
VZNIGHT |
April 2016 |
February 2019 |
February 2019 |
March 7, 2016 |
April 3, 2018 |
|
- Macha Research Trust
Choma, Zambia
|
|
| 26 |
NCT02688816 |
Completed |
Comparison of Cervical Cancer Screening Tests in HIV-infected Women in Lusaka, Zambia |
|
- Device: Xpert HPV
- Device: OncoE6
|
Observational
|
|
- Carla Chibwesha, MD
- National Cancer Institute (NCI)
- University of North Carolina, Chapel Hill
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Proportion of VIA-, Xpert HPV-, and OncoE6-positive results that are correctly identified
- Proportion of VIA-, Xpert HPV-, and OncoE6-negative results that are correctly identified
|
200 |
Female |
18 Years and older (Adult, Older Adult) |
NCT02688816 |
14-0399
3 D43 CA15378403S1 |
|
August 2014 |
June 2015 |
June 2015 |
February 23, 2016 |
February 23, 2016 |
|
- Adult Infectious Disease Centre at the University Teaching Hospital
Lusaka, Zambia
|
|
| 27 |
NCT02661763 |
Completed |
Rheumatic Heart Disease Study in Lusaka |
|
|
Observational
|
|
- University of Zambia
- University of Cape Town
- Novartis
|
Other / Industry |
- Observational Model: Ecologic or Community
- Time Perspective: Cross-Sectional
|
- Prevalence of RHD in Lusaka schoolchildren
|
1024 |
All |
10 Years to 21 Years (Child, Adult) |
NCT02661763 |
UNZABREC 002-10-13 |
|
September 2015 |
December 2015 |
December 2015 |
January 22, 2016 |
November 8, 2016 |
|
- University Teaching Hosptial
Lusaka, Zambia
|
|
| 28 |
NCT02654912 |
Recruiting |
Community-led Responses for Elimination: Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration |
|
- Drug: Reactive Focal Drug Administration
|
Interventional
|
Phase 4 |
- PATH
- Ministry of Health, Zambia
- AKROS Global Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Malaria seropositivity in children under five
- Incidence of malaria confirmed by RDT or microscopy as measured through passive case detection at health posts and health centers
- PCR parasite prevalence among individuals participating at 0, 30 and 90 days following a reactive research response for a period of 24 months
|
4800 |
All |
3 Months and older (Child, Adult, Older Adult) |
NCT02654912 |
PATH-WIRB-1155095 |
CORE Zambia |
February 2016 |
December 2018 |
June 2019 |
January 13, 2016 |
September 5, 2018 |
|
- Southern province medical office
Choma, Southern, Zambia
|
|
| 29 |
NCT02620436 |
Recruiting |
Impact Evaluation of Maternity Homes Access in Zambia |
|
- Other: Core Mother Shelter Model
|
Interventional
|
Not Applicable |
- Boston University
- University of Michigan
- Right to Care
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of women living more than 10 km from the facility who deliver at a health facility
- C-section rates among women living >10 km away from facility
- Maternal case fatality rate among women living >10 km away from facility
- (and 8 more...)
|
4900 |
Female |
15 Years and older (Child, Adult, Older Adult) |
NCT02620436 |
H34526 |
MAHMAZ |
March 2016 |
December 31, 2018 |
February 2019 |
December 3, 2015 |
June 7, 2018 |
|
|
|
| 30 |
NCT02612896 |
Recruiting |
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa? |
|
- Drug: Mass drug administration, praziquantel 10mg/kg
- Behavioral: Health education
|
Interventional
|
Not Applicable |
- Institute of Tropical Medicine, Belgium
- University of Zambia
- Ministry of Health, Zambia
- (and 2 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Other
|
- Change in porcine cysticercosis: in this One Health approach, the primary outcome is not a human measure
- Change in human cysticercosis active infection (serum: )
- Change in human cysticercosis, exposure to infection (serum)
- Change in human taeniasis (stool)
|
2900 |
All |
5 Years and older (Child, Adult, Older Adult) |
NCT02612896 |
CYSTISTOP_2.2_07012016 |
CYSTISTOP |
March 2016 |
September 2020 |
November 2020 |
November 24, 2015 |
August 28, 2018 |
|
- Nyembe and Mtandaza Rural Health Centre
Katete, Eastern Province, Zambia
|
|
| 31 |
NCT02573623 |
Unknown † |
Evaluation of an Innovative Tuberculosis Diagnostic Test |
|
|
Observational
|
|
- French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
- European and Developing Countries Clinical Trials Partnership (EDCTP)
|
Other |
- Time Perspective: Prospective
|
- Proportion of children with tuberculosis who are correctly identified by a immunoenzymatic test for tuberculosis as having the condition
- Proportion of tuberculosis negative children who are correctly identified as such by a immunoenzymatic test for tuberculosis
|
300 |
All |
up to 15 Years (Child) |
NCT02573623 |
ANRS12293 PROMISE-TB |
PROMISE-TB |
July 2013 |
October 2015 |
December 2015 |
October 12, 2015 |
October 12, 2015 |
|
- Department of Paediatrics and Child Health, University Teaching Hospital.UNZA-SOM
Lusaka, Zambia
|
|
| 32 |
NCT02516852 |
Completed |
Assessing the Effect of Sustainable Small-scale Egg Production on Maternal and Child Nutrition in Rural Zambia |
- Malnutrition, Child
- Malnutrition, Infant
|
|
Interventional
|
Not Applicable |
- Cornell University
- Community Markets for Conservation (COMACO)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in child height-for-age Z-score
- Change in household egg consumption
- Change in maternal egg consumption
- (and 4 more...)
|
3546 |
All |
6 Months to 36 Months (Child) |
NCT02516852 |
1402004456 |
|
June 2014 |
July 2016 |
May 2017 |
August 6, 2015 |
February 6, 2018 |
|
- COMACO
Mfuwe, Eastern Province, Zambia
|
|
| 33 |
NCT02459678 |
Completed |
ART Readiness in HIV-infected Pregnant Women |
- Human Immunodeficiency Virus
|
- Behavioral: Enhanced Adherence Package
- Other: Standard of Care
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Centre for Infectious Disease Research in Zambia
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of women who both initiate ART and are retained in care
- HIV virologic suppression at time of delivery
- Time from ART eligibility to ART initiation
- HIV transmission from mother to infant
|
454 |
All |
18 Years and older (Adult, Older Adult) |
NCT02459678 |
13-3884 |
|
May 2015 |
May 9, 2018 |
May 28, 2018 |
June 2, 2015 |
September 18, 2018 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 34 |
NCT02445846 |
Completed |
Dual Rapid HIV & Syphilis Tests in Zambia |
|
- Device: dual HIV/syphilis rapid diagnostics tests
|
Observational
|
|
- University of North Carolina, Chapel Hill
- World Health Organization
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- performance of dual rapid HIV/syphilis tests
- acceptability of use of dual rapid HIV/syphilis tests
|
3010 |
Female |
18 Years and older (Adult, Older Adult) |
NCT02445846 |
14-0528 |
|
May 2014 |
December 2015 |
January 2016 |
May 15, 2015 |
April 21, 2017 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 35 |
NCT02394522 |
Withdrawn |
Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Zambia (SR-M-ZM) |
|
- Device: Spatial Repellent product with active ingredient (SHIELD)
- Device: Active Ingredient
- Device: Spatial Repellent product without active ingredient (SHIELD)
|
Interventional
|
Not Applicable |
- University of Notre Dame
- Ministry of Health, Zambia
- Macha Research Trust, Zambia
- Johns Hopkins University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
0 |
All |
6 Months to 59 Months (Child) |
NCT02394522 |
SR-M-Zm |
SR-M-ZM |
March 2016 |
April 2016 |
April 2016 |
March 20, 2015 |
October 6, 2016 |
|
- Macha Research Trust
Macha, Choma, Zambia
|
|
| 36 |
NCT02386592 |
Completed |
Prevention of Nosocomial Bacteremia Among Zambian Neonates |
- Neonatal Sepsis
- Neonatal Mortality
|
- Drug: Chlorhexidine gluconate (CHG)
- Behavioral: Hand hygiene (HH)
- Behavioral: Infection control training
- Other: Infection control reminders via SMS text
|
Interventional
|
Not Applicable |
- Boston University
- University Teaching Hospital, Lusaka, Zambia
- Zambia Center for Applied Health Research and Development
- Children's Hospital of Philadelphia
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- All-cause neonatal mortality in hospitalized neonates
- Incidence of nosocomial bacteremia in hospitalized neonates
- Attributable risk of maternal, neonatal, hospital factors and nosocomial bacteremia among hospitalized neonates
- Prevalence of nosocomial bacteremia caused by MDR-GNR infections among hospitalized neonates
|
9410 |
All |
up to 28 Days (Child) |
NCT02386592 |
H-33473 |
|
September 1, 2015 |
April 15, 2017 |
July 2017 |
March 12, 2015 |
July 31, 2017 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 37 |
NCT02344680 |
Active, not recruiting |
Liver Fibrosis in Zambian HIV-HBV Co-infected Patients |
- Human Immunodeficiency Virus
- HBV
- Fibrosis, Liver
- (and 4 more...)
|
|
Observational
|
|
- University of Alabama at Birmingham
- John E. Fogarty International Center (FIC)
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in liver fibrosis stage
- Incidence of hepatocellular carcinoma
- Prevalence of significant liver fibrosis (Metavir F2 or greater)
- Risk factors for persistent HBV viremia 9Measure HBV DNA at baseline and month 12 and determine patient characteristics associated with unsuppressed HBV after 12 months of treatment)
|
400 |
All |
18 Years and older (Adult, Older Adult) |
NCT02344680 |
F150819001
1K01TW009998 |
|
October 2015 |
December 2018 |
December 2018 |
January 26, 2015 |
August 28, 2018 |
|
- Centre for Infectious Disease Research in Zambia (CIDRZ)
Lusaka, Zambia
|
|
| 38 |
NCT02329301 |
Active, not recruiting |
Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia |
- Malaria
- Malaria, Falciparum
|
- Drug: MDA with DHAp (Eurartesim)
- Drug: Focal MDA with DHAp (Eurartesim)
|
Interventional
|
Not Applicable |
- PATH
- Ministry of Health, Zambia
- Minister of Community Development, Mother and Child Health, Zambia
- Tulane University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Parasite prevalence during the high transmission season among children <6 years old (excluding neonates <1 month)
- P.falciparum infection incidence rate among individuals ≥3 months
- Total and confirmed outpatient (OPD) malaria case incidence and inpatient (IPD) malaria case incidence among all ages
- Malaria rapid diagnostic test test positivity rate from focal mass drug administration (fMDA) and mass drug administration (MDA) interventions (plus control group)
|
2430 |
All |
3 Months and older (Child, Adult, Older Adult) |
NCT02329301 |
PATH-WIRB-20140824 |
|
September 2014 |
June 2016 |
December 2018 |
December 31, 2014 |
September 5, 2018 |
|
- Southern province medical office
Choma, Southern, Zambia
|
|
| 39 |
NCT02242539 |
Completed |
Tools to Improve Parental Recognition of Developmental Deficits in Children |
- Malnutrition
- Child Development
|
- Behavioral: Height measurement poster
- Behavioral: Community-based monitoring
|
Interventional
|
Not Applicable |
- Boston University
- Harvard University
- Innovations for Poverty Action
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Height-for-age z-score
- Child development outcomes
- Mid-upper arm circumference (MUAC)
- Dietary intake
|
547 |
All |
6 Months to 18 Months (Child) |
NCT02242539 |
14-2948 |
|
September 2014 |
September 2015 |
September 2015 |
September 17, 2014 |
January 13, 2016 |
|
- Household sample
Chipata District, Zambia
|
|
| 40 |
NCT02189759 |
Completed
Has Results |
Kangaroo Mother Care to Prevent Hypothermia in Term Infants |
|
- Other: Continuous Kangaroo Mother Care to one hour after birth
- Other: Standard Kangaroo Mother Care to one hour after birth
- Other: Continuous Kangaroo Mother Care to discharge
- Other: Standard Kangaroo Mother Care to discharge
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of Infants With Axillary Temperature <36.0 Degrees Celsius
- Number of Infants With Axillary Temperature < 36.0 Degrees Celsius at Discharge
- Number Infants Admitted to the Neonatal Intensive Care Unit
- Duration of Kangaroo Mother Care
|
375 |
All |
up to 2 Weeks (Child) |
NCT02189759 |
UAB Neo 012 |
|
August 2014 |
September 2014 |
September 2014 |
July 15, 2014 |
June 19, 2017 |
June 19, 2017 |
- University Teaching Hospital
Lusaka, Zambia
|
|
| 41 |
NCT02189746 |
Completed |
Kangaroo Mother Care to Prevent Hypothermia in Preterm Infants |
|
- Other: Continuous Kangaroo Mother Care to 1 hour after birth
- Other: Standard Kangaroo Mother Care to 1 hour after birth
- Other: Continuous Kangaroo Mother Care to discharge
- Other: Standard Kangaroo Mother Care to discharge
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature < 36.0 degrees Celsius
- Axillary Temperature < 36.0 degrees Celsius
- Blood pressure
- (and 8 more...)
|
140 |
All |
up to 8 Weeks (Child) |
NCT02189746 |
UAB Neo 011 |
|
June 2014 |
August 2017 |
August 2017 |
July 15, 2014 |
January 10, 2018 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 42 |
NCT02081521 |
Completed |
Evaluation of a Multiple Behaviour Programme for Diarrhoea Management |
|
- Behavioral: Community behaviour change campaign
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- Centre for Infectious Disease Research in Zambia
- Absolute Return for Kids
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in target behaviour: zinc use
- Change in target behaviour: correct ORS preparation
- Change in target behaviour: Exclusive breastfeeding
- (and 9 more...)
|
640 |
All |
1 Month to 59 Months (Child) |
NCT02081521 |
QA511 |
|
January 2014 |
November 2014 |
November 2014 |
March 7, 2014 |
March 11, 2016 |
|
- Centre for Infectious Disease Research Zambia
Lusaka, Lusaka Province, Zambia
|
|
| 43 |
NCT02060162 |
Active, not recruiting |
Antiretroviral Treatment Outcomes in HIV-HBV Co-infected Patients in Southern Africa |
- Hepatitis B Virus
- HIV
- Antiretroviral Therapy
- (and 3 more...)
|
|
Observational
|
|
- University of Alabama at Birmingham
- Centre for Infectious Disease Research in Zambia
- University of Bern
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Immunological response
- HIV virological response
- Mortality
- (and 6 more...)
|
900 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT02060162 |
F160229001 |
|
October 2013 |
June 2021 |
June 2021 |
February 11, 2014 |
June 5, 2018 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 44 |
NCT02058927 |
Completed |
Immune Reconstitution to Measles Virus of HIV Infected Children in Zambia |
|
|
Observational
|
|
- University of North Carolina, Chapel Hill
- National Institute of Allergy and Infectious Diseases (NIAID)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Memory immune responses to measles virus
- Humoral and cellular immune responses to measles virus before and after revaccination
|
203 |
All |
9 Months to 10 Years (Child) |
NCT02058927 |
CIDRZ 1204/IRB12-0400
R01AI070018 |
|
May 2011 |
February 2012 |
February 2012 |
February 10, 2014 |
September 18, 2014 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 45 |
NCT02054780 |
Completed |
Randomized Controlled Trial of Ways to Improve OVC HIV Prevention and Well-being |
- Risk Behavior
- Mental Health Impairment
|
- Behavioral: Trauma-Focused Cognitive Behavioral Therapy
- Behavioral: Psychosocial Counseling
|
Interventional
|
Not Applicable |
- Johns Hopkins Bloomberg School of Public Health
- SHARPZ (Serenity Harm Reduction Programme Zambia)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in HIV Risk Behavior as measured by the World Aids Foundation (WAF) survey
- Change in Mental Health and Well-being
- Change in Caregiver mental health and well-being
- Cost Effectiveness of TF-CBT and PC
|
610 |
All |
13 Years to 17 Years (Child) |
NCT02054780 |
5R01HD070720 |
|
February 2014 |
November 2017 |
November 2017 |
February 4, 2014 |
April 5, 2018 |
|
- Serenity Harm Reduction Programme Zambia (SHARPZ)
Lusaka, Zambia
|
|
| 46 |
NCT02053142 |
Completed |
Acyclovir Therapy for Genital Herpes Ulcers in HIV Negative African Women |
- Ulcers of Female Genital Organs
|
- Drug: Acyclovir
- Drug: Placebo
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- National Institute of Allergy and Infectious Diseases (NIAID)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Area under the Curve (AUC)
- Time to re-epithelization and time to cessation of HSV shedding
|
74 |
Female |
18 Years to 50 Years (Adult) |
NCT02053142 |
CIDRZ 1208/IRB12-0390 |
|
January 2009 |
December 2009 |
December 2009 |
February 3, 2014 |
September 15, 2017 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 47 |
NCT02053129 |
Completed |
Evaluation of PTB Screening in ANC in Lusaka, Zambia |
|
- Other: TB screening Questionnaire
- Other: Sputum smear and culture (only in HIV negative women who are symptomatic)
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Centre for Infectious Disease Research in Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- number of positive pulmonary tuberculosis (PTB) tests
- Sensitivity and specificity of symptom-based TB screening
|
5033 |
Female |
18 Years to 99 Years (Adult, Older Adult) |
NCT02053129 |
CIDRZ 1217/IRB12-0417 |
|
November 2011 |
October 2012 |
December 2013 |
February 3, 2014 |
September 15, 2017 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 48 |
NCT02043080 |
Completed |
Optimizing Clinical Outcomes in HIV-Infected Adults & Children |
- Tuberculosis Diagnosis
- HIV
|
- Other: Xpert MTB/RIF Tuberculosis diagnostic tool
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Proportions of adult and paediatric patients receiving appropriate TB treatment in each study phase
- Clinical outcomes of subjects screened using the Xpert MTB/RIF algorithm compared to existing standard of care.
|
1436 |
All |
up to 99 Years (Child, Adult, Older Adult) |
NCT02043080 |
12-1402 |
|
August 2012 |
March 2016 |
April 2017 |
January 23, 2014 |
August 3, 2017 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 49 |
NCT02043067 |
Completed |
Enhanced TB Screening to Determine the Prevalence and Incidence of TB in Patients With HIV |
|
- Other: Comprehensive TB screening
|
Observational
|
|
- University of North Carolina, Chapel Hill
- Centre for Infectious Disease Research in Zambia
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Prevalence of undiagnosed TB in those with HIV.
- Incidence of TB in a cohort of HIV clinic patients screened as 'TB negative'.
|
400 |
All |
16 Years to 99 Years (Child, Adult, Older Adult) |
NCT02043067 |
CIDRZ 1226/IRB12-0416 |
|
October 2011 |
September 2012 |
May 2013 |
January 23, 2014 |
September 15, 2017 |
|
- Kalingalinga HIV Care and Treatment Clinic
Lusaka, Zambia
|
|
| 50 |
NCT02012816 |
Completed |
The Use of Peer Referral Incentives to Increase Demand for Voluntary Medical Male Circumcision in Zambia |
|
- Other: Peer‐referral incentive program to increase VMMC uptake
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Centers for Disease Control and Prevention
- Centre for Infectious Disease Research in Zambia
|
Other / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Primary outcome will be the number of men coming for circumcision in each clinic during the intervention period divided by the adult male population in the catchment area of each clinic.
|
725 |
Male |
18 Years to 49 Years (Adult) |
NCT02012816 |
CIDRZ 1310 |
|
June 2014 |
September 2015 |
November 2015 |
December 16, 2013 |
June 6, 2016 |
|
- Center for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 51 |
NCT01951794 |
Completed |
Validation of a Community Survey Methodology for Measuring PMTCT Program Impact |
|
|
Observational
|
|
- University of North Carolina, Chapel Hill
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Ecologic or Community
- Time Perspective: Cross-Sectional
|
- HIV-free survival among HIV-exposed infants.
|
827 |
All |
up to 49 Years (Child, Adult) |
NCT01951794 |
CIDRZ 1225
R01HD075131-01 |
|
June 2014 |
November 2016 |
December 2016 |
September 27, 2013 |
April 19, 2017 |
|
- Centre for Infectious Disease Reseach in Zambia
Lusaka, Zambia
|
|
| 52 |
NCT01942278 |
Completed |
Better Health Outcomes Through Mentoring and Assessment (BHOMA) |
|
|
Interventional
|
Not Applicable |
- University of North Carolina, Chapel Hill
- Doris Duke Charitable Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Age standardized mortality rates in those aged <60 years.
- Mortality in those aged <5 years.
|
207517 |
All |
Child, Adult, Older Adult |
NCT01942278 |
CIDRZ 1229 |
BHOMA |
January 2011 |
August 2016 |
August 2016 |
September 13, 2013 |
April 14, 2017 |
|
- Center for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 53 |
NCT01924546 |
Completed |
Study of Dehydration and Cognition in Pupils in Zambia |
|
|
Interventional
|
Not Applicable |
- Emory University
- FHI 360
- United States Agency for International Development (USAID)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in cognitive test performance
- Change in perceived difficulty of task
- Change in hydration status
|
292 |
All |
6 Years to 18 Years (Child, Adult) |
NCT01924546 |
IRB00065861 |
|
August 2013 |
October 2013 |
October 2013 |
August 16, 2013 |
August 21, 2014 |
|
|
|
| 54 |
NCT01922713 |
Completed |
Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women |
|
- Other: white maize and a corn oil capsule
- Other: orange maize and a corn oil capsule
- Other: white maize and a vitamin A capsule
|
Interventional
|
Not Applicable |
- University of California, Davis
- Johns Hopkins University
- Tropical Diseases Research Centre, Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
|
- Breast milk retinol concentration
- Breastmilk beta-carotene concentration
|
149 |
Female |
18 Years to 35 Years (Adult) |
NCT01922713 |
HP-8282 |
|
October 2013 |
December 2013 |
December 2014 |
August 14, 2013 |
January 26, 2015 |
|
- Center for Human Nutrition
Mkushi, Mkushi District, Zambia
|
|
| 55 |
NCT01886833 |
Completed
Has Results |
Causes of Rotavirus Vaccine Failure in Zambian Children |
|
|
Observational
|
|
- Centre for Infectious Disease Research in Zambia
- National Institute of Allergy and Infectious Diseases (NIAID)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of Immunized Infants Exposed to High Breast Milk Anti-rotavirus Immunoglobulin-A Who Fail to Seroconvert
- Proportion of Immunized Infants Exposed to Transplacentally-acquired, Rotavirus-specific, Infant Serum IgG Who Fail to Sero-convert.
- Proportion of Immunized Infants Exposed to Maternal HIV Infection Who Fail to Seroconvert
- Proportion of Immunized Infants With Low Micronutrient Levels (as Indicated by Serum Zinc and Vitamin A), Who Fail to Seroconvert
|
420 |
All |
6 Weeks to 15 Weeks (Child) |
NCT01886833 |
ROVAS 01
1R01AI099601-01 |
|
April 1, 2012 |
April 30, 2015 |
April 30, 2016 |
June 26, 2013 |
August 23, 2018 |
August 23, 2018 |
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 56 |
NCT01878734 |
Completed |
Zambia Micronutrient Powder Trial Effectiveness Study |
- Iron Deficiency Anaemia
- Stunting
|
- Dietary Supplement: Micronutrient Powders
|
Interventional
|
Not Applicable |
- University of British Columbia
- Tropical Disease Research Centre
- UNICEF
- Ministry of Health, Zambia
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change from Baseline in the occurrence of Iron Deficiency Anemia
- Change from Baseline in the Occurrence of Stunting
|
631 |
All |
6 Months to 11 Months (Child) |
NCT01878734 |
H13-00261 |
|
June 2013 |
November 2014 |
November 2014 |
June 17, 2013 |
June 4, 2015 |
|
- Villages in the Mbala District
Mbala, Northern Province, Zambia
|
|
| 57 |
NCT01844102 |
Completed |
Safety and Acceptability of the PrePex™ Device for Male Circumcision in Zambia |
|
|
Interventional
|
Phase 4 |
- FHI 360
- Population Services International
- Population Council
- (and 2 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Adverse Events
- Acceptability of PrePex procedures among male circumcision providers
- Proportion of men ineligible for circumcision with PrePex
- (and 3 more...)
|
500 |
Male |
18 Years to 49 Years (Adult) |
NCT01844102 |
416416 |
|
October 2013 |
April 2014 |
April 2014 |
May 1, 2013 |
May 13, 2014 |
|
- Society for Family Health
Lusaka, Zambia
|
|
| 58 |
NCT01695148 |
Completed |
Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children |
- Vitamin A Deficiency
- Low Serum Retinol
|
- Dietary Supplement: β-Carotene Biofortified Maize Flour
- Dietary Supplement: White Maize Flour
|
Interventional
|
Phase 3 |
- Johns Hopkins Bloomberg School of Public Health
- National Food and Nutrition Commission, Zambia
- Tropical Diseases Research Centre, Zambia
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Increased Serum Retinol Concentration
- Decreased Prevalence of Vitamin A deficiency
- Improved Dark Adaptation
|
1228 |
All |
4 Years to 8 Years (Child) |
NCT01695148 |
JHU IRB 4150 |
|
August 2012 |
March 2013 |
June 2013 |
September 27, 2012 |
February 7, 2014 |
|
|
|
| 59 |
NCT01688167 |
Completed |
Increasing Availability and Acceptability of Circumcision in Zambia |
|
- Behavioral: MC and sexual risk reduction
|
Interventional
|
Not Applicable |
- University of Miami
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
- Change in likelihood of undergoing male circumcision across the study using stages of change model
- Uptake of male circumcision
|
1468 |
All |
18 Years and older (Adult, Older Adult) |
NCT01688167 |
20110290
R01MH095539 |
|
January 2012 |
November 2014 |
November 2014 |
September 19, 2012 |
July 10, 2015 |
|
- University of Zambia Teaching Hospital
Lusaka, Zambia
|
|
| 60 |
NCT01687621 |
Completed |
Omphalitis Community Based Algorithm Validation Study |
|
- Procedure: Diagnostic Algorithm for Community Based Worker for Omphalitis
|
Observational
|
|
- Boston University
- Bill and Melinda Gates Foundation
- Thrasher Research Fund
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Validity of the omphalitis algorithm
|
1009 |
All |
up to 10 Days (Child) |
NCT01687621 |
OCAVS |
OCAVS |
September 2012 |
July 2013 |
July 2013 |
September 19, 2012 |
July 22, 2015 |
|
- Hospitals & Community Health Centers
Livingstone, Southern Province, Zambia
|
|
| 61 |
NCT01663701 |
Unknown † |
Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia |
- Sepsis
- Severe Sepsis
- Tuberculosis
|
- Other: Simplified severe sepsis protocol
- Other: Usual care
|
Interventional
|
Not Applicable |
- Vanderbilt University
- National Institutes of Health (NIH)
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- In-hospital all cause mortality
- 28-day all-cause mortality
- In-hospital all cause mortality adjusted for illness severity
- (and 4 more...)
|
212 |
All |
18 Years and older (Adult, Older Adult) |
NCT01663701 |
SSSP-2
R24TW007988 |
SSSP-2 |
August 2012 |
July 2013 |
September 2013 |
August 13, 2012 |
August 14, 2012 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 62 |
NCT01624298 |
Unknown † |
Randomized Control Trial on Trauma Focused CBT in Zambia |
- Post Traumatic Stress Disorder
- Depression
- Risk Behaviors
|
- Behavioral: Trauma Focused Cognitive Behavioral Therapy
|
Interventional
|
Phase 2 |
- Johns Hopkins Bloomberg School of Public Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Post Traumatic Stress Disorder- Reaction Index
- World AIDS Foundation (WAF)
- Child Behavior Checklist
|
250 |
All |
5 Years to 18 Years (Child, Adult) |
NCT01624298 |
TFCBTRCTDCOF |
|
August 2012 |
September 2013 |
December 2013 |
June 20, 2012 |
July 23, 2013 |
|
- Serenity Harm Reduction Programme Zambia
Lusaka, Zambia
|
|
| 63 |
NCT01604460 |
Completed |
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part V |
|
- Procedure: Resuscitation with torso plastic bag
- Procedure: Resuscitation-no plastic bag
|
Interventional
|
Phase 4 |
- University of Alabama at Birmingham
- Children's Health System, Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature < 36.5 degrees Celsius
- Sepsis
- Death
- (and 2 more...)
|
275 |
All |
up to 72 Hours (Child) |
NCT01604460 |
UAB Neo 010 |
|
June 2012 |
August 2012 |
November 2012 |
May 23, 2012 |
February 11, 2013 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 64 |
NCT01604447 |
Completed |
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV |
|
- Procedure: Hypothermia prevention with plastic bag
- Procedure: Hypothermia prevention without plastic bag
|
Interventional
|
Phase 4 |
- University of Alabama at Birmingham
- Children's of Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature 36.5-37.5 degrees Celsius
- Blood pressure
- Blood glucose
- (and 14 more...)
|
118 |
All |
up to 72 Hours (Child) |
NCT01604447 |
UAB Neo 009 |
|
June 2012 |
August 2014 |
February 2015 |
May 23, 2012 |
February 24, 2015 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 65 |
NCT01604434 |
Recruiting |
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III |
|
- Procedure: Incubator-torso bag
- Procedure: Incubator-no plastic bag
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Children's Health System, Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature 36.5-37.5 degrees Celsius
- Blood Pressure
- Blood glucose
- (and 13 more...)
|
118 |
All |
up to 72 Hours (Child) |
NCT01604434 |
UAB Neo 008 |
|
June 2012 |
October 2018 |
October 2019 |
May 23, 2012 |
November 22, 2017 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 66 |
NCT01604421 |
Recruiting |
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II |
|
- Procedure: Thermoregulation-standard care
- Procedure: Thermoregulation with plastic bag
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Children's Health System, Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature < 36.5 degrees Celsius
- Seizure
- Respiratory Distress Syndrome (RDS)
- (and 6 more...)
|
182 |
All |
up to 120 Days (Child) |
NCT01604421 |
UAB Neo 007 |
|
February 2013 |
October 2018 |
October 2019 |
May 23, 2012 |
November 22, 2017 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 67 |
NCT01604317 |
Recruiting |
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I |
- Hypothermia
- Immature Newborn
|
- Procedure: Resuscitation-torso plastic bag
- Procedure: Resuscitation-partial-head plastic bag
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Children's Health System, Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature < 36.5 degrees Celsius
- Seizure
- Respiratory Distress Syndrome (RDS)
- (and 6 more...)
|
182 |
All |
up to 1 Hour (Child) |
NCT01604317 |
UAB Neo 005 |
|
June 2012 |
October 2018 |
October 2019 |
May 23, 2012 |
November 22, 2017 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 68 |
NCT01449916 |
Unknown † |
Simplified Severe Sepsis Protocol in Zambia |
|
- Other: Simplified Severe Sepsis Protocol
|
Interventional
|
Not Applicable |
- Vanderbilt University
- National Institutes of Health (NIH)
- John E. Fogarty International Center (FIC)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- In-hospital all cause mortality
- 28-day all-cause mortality
- In-hospital all cause mortality adjusted for illness severity
- (and 4 more...)
|
348 |
All |
18 Years and older (Adult, Older Adult) |
NCT01449916 |
SSSP
R24TW007988 |
SSSP |
February 2012 |
October 2012 |
November 2012 |
October 10, 2011 |
June 7, 2012 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 69 |
NCT01403623 |
Completed |
Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates |
|
- Procedure: Resuscitation and post resuscitation care with plastic bag
- Procedure: Resuscitation- no plastic bag for temperature regulation
|
Interventional
|
Phase 4 |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Axillary temperature 36.5-37.5 degrees Celsius
- Blood pressure
- Blood glucose
- (and 10 more...)
|
106 |
All |
Child, Adult, Older Adult |
NCT01403623 |
UAB Neo 003 |
|
August 2011 |
March 2012 |
December 2012 |
July 27, 2011 |
August 21, 2013 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 70 |
NCT01397851 |
Completed
Has Results |
Stimulating Private Sector Malaria Control |
|
- Device: Insecticide-treated net (BASF Incerceptor)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Cotton Yields
- Contract Defaults
- Increase in Maize Productivity
- Self-reported Malaria Prevalence
|
81597 |
All |
Child, Adult, Older Adult |
NCT01397851 |
PATH Outgrowers |
Outgrowers |
December 2010 |
December 2011 |
December 2013 |
July 20, 2011 |
January 15, 2015 |
January 15, 2015 |
- National Malaria Control Centre
Lusaka, Zambia
|
|
| 71 |
NCT01376336 |
Unknown † |
Trial of Safe Water Storage Among People Living With HIV |
- Diarrhea
- Waterborne Disease
- HIV
|
- Device: Safe storage device
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- University of Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Self-reported diarrheal disease
- Weight-for-age z-score
- E. coli and total coliforms in household drinking water
- Salivary antibody response
|
1600 |
All |
Child, Adult, Older Adult |
NCT01376336 |
QA308 |
|
August 2011 |
August 2013 |
August 2013 |
June 20, 2011 |
June 20, 2011 |
|
- Tropical Gastroenterology and Nutrition Group (TROPGAN), University of Zambia School of Medicine
Lusaka, Zambia
|
|
| 72 |
NCT01368354 |
Completed |
Taenia Solium Control Case Study in Zambia |
- Cysticercosis
- Helminthiasis
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of porcine/human cysticercosis cases (serological test)
- Number of STH cases in humans
|
1197 |
All |
Child, Adult, Older Adult |
NCT01368354 |
ICONZ-UNZA |
SANTOSOIL |
April 2012 |
January 2015 |
January 2015 |
June 7, 2011 |
February 11, 2015 |
|
- Katete
Katete district, Eastern, Zambia
|
|
| 73 |
NCT01241318 |
Completed |
Zambia Chlorhexidine Application Trial |
|
- Drug: Chlorhexidine gluconate (4%)
- Procedure: Dry cord care
|
Interventional
|
Phase 2
Phase 3 |
- Boston University
- Bill and Melinda Gates Foundation
- Ministry of Health, Zambia
- Zambia Center for Applied Health Research and Development
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- All-cause neonatal mortality
- All-cause neonatal mortality among newborns who survived at least first day of life
- Incidence of omphalitis
- (and 3 more...)
|
77535 |
All |
Child, Adult, Older Adult |
NCT01241318 |
ZamCAT |
ZamCAT |
February 2011 |
September 2013 |
September 2013 |
November 16, 2010 |
January 29, 2015 |
|
- Facilities throughout Southern Province
Choma, Southern Province, Zambia
|
|
| 74 |
NCT01116908 |
Completed |
Safe Drinking Water For Households With Infants Born to HIV-Positive Mothers Pilot Study |
|
|
Interventional
|
Not Applicable |
- London School of Hygiene and Tropical Medicine
- University Teaching Hospital, Lusaka, Zambia
- University of Zambia
- Vestergaard Frandsen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Use of LifeStraw Family for children under 2 and all household members
- Microbiological performance of LifeStraw Family
- Impact of LifeStraw Family on longitudinal prevalence of diarrhea
|
120 |
Female |
Child, Adult, Older Adult |
NCT01116908 |
QA270 |
SWIM |
April 2010 |
August 2011 |
August 2011 |
May 5, 2010 |
August 15, 2011 |
|
- Ngwerere Health Clinic and Kasisi Health Clinic
Lusaka, Chongwe District, Lusaka Province, Zambia
|
|
| 75 |
NCT01115335 |
Completed |
Feasibility, Acceptability, and Safety of Neonatal Male Circumcision in Lusaka, Zambia |
- Neonatal Male Circumcision
|
- Procedure: Neonatal male circumcision
|
Interventional
|
Phase 4 |
- University of Alabama at Birmingham
- University Teaching Hospital, Lusaka, Zambia
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Complication Rate
- Uptake of NMC
- Provider Preferences
- Parent Satisfaction
|
661 |
Male |
up to 28 Days (Child) |
NCT01115335 |
PS123541-06 |
|
October 2009 |
March 2011 |
January 2012 |
May 4, 2010 |
July 13, 2012 |
|
- University Teaching Hospital and Matero Reference Clinic
Lusaka, Zambia
|
|
| 76 |
NCT01088516 |
Completed |
Clinical Study of an Aluvia-based HAART Regimen for Prevention of Mother-to-child HIV Transmission in Africa |
|
- Drug: Lopinavir/Ritonavir (200/50 mg) Tablets + Zidovudine + 3TC
|
Interventional
|
Phase 4 |
- University of Zambia
- University of Toronto
- Abbott
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HIV Negative Survival of Infants
- Maternal survival, viral suppression and CD4 response
- Emergence of viral drug resistance in mothers or infants
- (and 3 more...)
|
280 |
Female |
15 Years and older (Child, Adult, Older Adult) |
NCT01088516 |
Aluvia Breastfeeding Study
A10-324 |
|
December 2008 |
November 2011 |
May 2012 |
March 17, 2010 |
June 24, 2015 |
|
- Chelstone Clinic
Lusaka, Zambia
|
|
| 77 |
NCT01053325 |
Completed |
Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy |
- Malaria in Pregnancy
- HIV Infections
|
- Drug: Cotrimoxazole prophylaxis
- Drug: SP IPT
|
Interventional
|
Phase 3 |
- Institute of Tropical Medicine, Belgium
- Tropical Diseases Research Centre, Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- To establish that in HIV negative pregnant women co-trimoxazole prophylaxis is non inferior to SP IPT with respect to birth weight at delivery (or within 24 hours). Non inferiority is defined as a difference in mean birth weights of no more than 100g.
- To evaluate the effectiveness of co-trimoxazole prophylaxis and SP IPT in reducing placenta malaria in HIV+ pregnant women with CD4 ≥ 350/µl and in the combined group of HIV- and HIV+ pregnant women with CD4 ≥ 350/µl
- To evaluate the effectiveness of CTX and SP IPT in reducing malaria peripheral infection, in HIV negative, and in HIV positive pregnant women with a CD4 cell count ≥ 350/µl
- (and 2 more...)
|
848 |
Female |
Child, Adult, Older Adult |
NCT01053325 |
ITMP0409 |
|
September 2010 |
December 2012 |
February 2013 |
January 21, 2010 |
October 24, 2013 |
|
- Kabuta Health Centre
Kabuta, Nchelenge District, Luapula Province of, Zambia
|
|
| 78 |
NCT00929604 |
Completed |
HIV Viral Load Monitoring in Resource-Poor Settings |
|
- Other: HIV-1 viral load testing
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Adult AIDS Clinical Trials Group
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Patient survival
- To assess HIV clinical disease progression (weight, CD4 cell response, incident opportunistic infections)
- To assess the impact of more rapid ART regimen switching on available second and third-line treatment options
- (and 3 more...)
|
2112 |
All |
18 Years and older (Adult, Older Adult) |
NCT00929604 |
VLS |
|
December 2006 |
May 2012 |
June 2014 |
June 29, 2009 |
October 9, 2014 |
|
- Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 79 |
NCT00816842 |
Completed |
Plasma Citrulline Concentration in Tropical Enteropathy |
- Malabsorption Syndromes
- Granulomatous Enteritis
- Enteritis
- (and 2 more...)
|
|
Observational
|
|
- Azienda Ospedaliero-Universitaria di Parma
|
Other |
|
- postabsorptive plasma citrulline concentration
- intestinal permeability ratio
|
|
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00816842 |
EC3184
Prot 84 24/01/06 |
|
October 1998 |
May 2008 |
September 2008 |
January 5, 2009 |
January 5, 2009 |
|
- Department of Medicine, University of Zambia School of Medicine, University Teaching Hospital
Lusaka, Lusaka province, Zambia
|
|
| 80 |
NCT00807625 |
Completed |
Impact of Different Contraceptives on the Immune System of HIV Infected Women in Zambia |
- HIV
- Contraception
- HIV Infections
|
- Drug: Depo Provera
- Device: Copper T Intrauterine contraception device
|
Interventional
|
Phase 2 |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- T-cell activation
- CD4+ cell decline
- Cervical viral load
|
66 |
Female |
16 Years and older (Child, Adult, Older Adult) |
NCT00807625 |
F071227004 |
MSRC |
November 2008 |
July 2010 |
July 2010 |
December 12, 2008 |
July 13, 2012 |
|
- The Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
|
|
| 81 |
NCT00753428 |
Completed |
Community-based Evaluation of a Pilot PMTCT Project in Kafue District |
|
- Other: Community-based Survey
|
Observational
|
|
- University of North Carolina, Chapel Hill
- Doris Duke Charitable Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Population HIV-free survival
|
4129 |
All |
Child, Adult, Older Adult |
NCT00753428 |
12-0399
X080331005 |
|
November 2008 |
November 2011 |
November 2011 |
September 16, 2008 |
April 19, 2018 |
|
- Centre for Infectious Disease Reseach in Zambia
Lusaka, Zambia
|
|
| 82 |
NCT00753324 |
Completed |
Routine Use of Antiretroviral Therapy to Prevent Mother-to-Child HIV Transmission in the Kafue District of Zambia |
|
- Drug: Routine three-drug antiretroviral prophylaxis
|
Interventional
|
Phase 4 |
- University of North Carolina, Chapel Hill
- Doris Duke Charitable Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HIV Infection
- Infant survival
- HIV-free survival
- Incidence of maternal toxicity to HAART regimens
|
284 |
Female |
Child, Adult, Older Adult |
NCT00753324 |
CIDRZ 1222/F070821006 |
|
May 2009 |
January 2012 |
January 2012 |
September 16, 2008 |
March 29, 2016 |
|
|
|
| 83 |
NCT00572754 |
Unknown † |
Phase II Trial to Evaluate the Safety and Efficacy of the Dry Circumcision Method |
|
|
Interventional
|
Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The operative and short-term post-operative safety rates
- Mobibidity and mortality The length of the residual foreskin.
|
15 |
Male |
21 Years and older (Adult, Older Adult) |
NCT00572754 |
Drycirc Vz10d
NEB002180 |
|
November 2007 |
|
March 2008 |
December 13, 2007 |
December 13, 2007 |
|
- University Teaching Hospital
Lusaka, Zambia
|
|
| 84 |
NCT00513500 |
Completed
Has Results |
Zambia Integrated Management of Malaria and Pneumonia Study |
|
- Drug: Coartem and amoxicillin
- Drug: Coartem
|
Interventional
|
Not Applicable |
- Boston University
- Center for International Health and Development
- United States Agency for International Development (USAID)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Number of Children Who Received Early and Appropriate Treatment for Pneumonia.
- Number of Children With Fever Who Received Coartem (Artemether-lumefantrine)
- Number of Children Who do Not Respond to Treatment for Pneumonia
|
3125 |
All |
6 Months to 5 Years (Child) |
NCT00513500 |
GHS-A-00-00020-00-5 |
ZIMMAPS |
June 2007 |
February 2009 |
September 2009 |
August 8, 2007 |
July 20, 2010 |
July 13, 2010 |
- Chikankata Health Services
Chikankata, Southern Province, Zambia
|
|
| 85 |
NCT00378118 |
Completed |
Use of OraQuick for Screening HIV in Children Less Than Eighteen Months Old |
|
- Other: Abbott-rapid HIV antibody test
- Other: OraQuick Rapid HIV-1/2 Antibody test
|
Observational
|
|
- Thrasher Research Fund
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Sensitivity and specificity of the OraQuick rapid test
- Acceptance of HIV testing using oral fluid
|
1000 |
All |
up to 18 Months (Child) |
NCT00378118 |
ThrasherRF
IRB00001131 of IORG0000774 |
|
December 2006 |
|
September 2007 |
September 19, 2006 |
November 6, 2007 |
|
- University Teaching Hospital,Department of Pediatrics
Lusaka, Zambia
|
|
| 86 |
NCT00373048 |
Completed |
Mefloquine Prophylaxis in HIV-1 Individuals: a Randomized Placebo-controlled Trial |
|
- Drug: mefloquine
- Drug: placebo
|
Interventional
|
Not Applicable |
- Institute of Tropical Medicine, Belgium
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Rate of decline of CD4 counts between different time points
- Proportion of patients entering the AIDS stage (WHO stage 3,4)
- Mean difference in log plasma viral load at different time points,
- (and 6 more...)
|
300 |
All |
18 Years to 50 Years (Adult) |
NCT00373048 |
Mefloquine HIV zambia |
|
October 2005 |
December 2007 |
May 2011 |
September 7, 2006 |
May 24, 2011 |
|
- Tropical Disease Research Center
Ndola, Cupperbelt, Zambia
|
|
| 87 |
NCT00349323 |
Completed |
Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia |
- Soil-Transmitted Helminth Infection
- Growth
|
- Behavioral: Community directed treatment
|
Observational
|
|
- DBL -Institute for Health Research and Development
- Department of Community Medicine & Department of Biological Sciences
- University of Zambia
|
Other |
- Time Perspective: Prospective
|
|
100 |
All |
12 Months to 59 Months (Child) |
NCT00349323 |
2006-7041-83/hah |
|
August 2006 |
August 2007 |
September 2007 |
July 7, 2006 |
May 8, 2008 |
|
- Mazabuka District
Mazabuka, Zambia
|
|
| 88 |
NCT00310726 |
Completed |
Zambia Exclusive Breastfeeding Study |
|
- Other: abrupt weaning at 4 months
- Other: Continued exclusive breastfeeding
|
Interventional
|
Not Applicable |
- Boston Medical Center
- United States Agency for International Development (USAID)
- National Institutes of Health (NIH)
|
Other / U.S. Fed / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HIV infection detected by 4 months among children with no evidence of HIV infection at birth.
- Magnitude of the reduction in mother-to-child HIV transmission and the magnitude of the increase in non-HIV-related under-2-year mortality, attributable to cessation of breastfeeding at 4 months.
|
1435 |
Female |
18 Years to 40 Years (Adult) |
NCT00310726 |
R01HD039611 |
|
May 2001 |
December 2006 |
December 2006 |
April 4, 2006 |
July 27, 2011 |
|
- George and Chawama District Health Clinics
Lusaka, Zambia
|
|
| 89 |
NCT00304980 |
Terminated |
Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status |
- Plasmodium Falciparum Malaria
|
- Drug: ARTEMETHER + LUMEFANTRINE VS. SULFADOXINE + PYRIMETHAMINE
|
Interventional
|
Not Applicable |
- Institute of Tropical Medicine, Belgium
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- PCR corrected clinical and parasitological outcome at day 45
- Tolerability
- Clinical recovery
|
3000 |
All |
15 Years to 45 Years (Child, Adult) |
NCT00304980 |
02 52 5 406 |
|
March 2003 |
|
April 2005 |
March 21, 2006 |
September 14, 2010 |
|
- Tropical Disease Research Center
Ndola, Cupperbelt, Zambia
|
|
| 90 |
NCT00276224 |
Completed |
Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia |
- Schistosomiasis
- Helminthiases
- Anaemia
|
- Drug: ferrous sulphate (drug)
|
Interventional
|
Not Applicable |
- DBL -Institute for Health Research and Development
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9
- Stool samples examined for schistsoma mansoni at mont 0, 3, 6 and 9
- Blood samples examined for haemoglobin level mont 0 and month 9
- (and 8 more...)
|
480 |
All |
9 Years to 15 Years (Child) |
NCT00276224 |
SRP-ZM-VM-04 |
|
September 2005 |
|
April 2006 |
January 13, 2006 |
October 31, 2007 |
|
- Kenani and Chandwe School
Kenani, Nchelenge district, Zambia
|
|
| 91 |
NCT00270530 |
Completed |
Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia |
- Placental Malaria Infection
- HIV Infections
- Stillbirth
- (and 2 more...)
|
- Drug: Sulfadoxine-pyrimethamine (Fansidar)
|
Interventional
|
Phase 4 |
- Center for International Health and Development
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- • Prevalence of placental malaria infection
- • Prevalence of maternal peripheral parasitemia
- • Birth weight, including the proportion of LBW infants
- (and 6 more...)
|
454 |
Female |
18 Years to 50 Years (Adult) |
NCT00270530 |
S1954-21/22-2 |
|
November 2002 |
|
October 2004 |
December 28, 2005 |
January 31, 2006 |
|
- Tropical Diseases Research Centre
Ndola, Zambia
|
|
| 92 |
NCT00247091 |
Completed |
Impact of HIV on Measles and Measles Immunisation |
- HIV Infection
- Measles
- Children
|
- Biological: standard-titer measles vaccine
|
Observational
|
|
- Johns Hopkins Bloomberg School of Public Health
- Burroughs Wellcome
- London School of Hygiene and Tropical Medicine
- University of Zambia
|
Other / Industry |
- Observational Model: Defined Population
- Observational Model: Natural History
- Time Perspective: Longitudinal
- Time Perspective: Prospective
|
|
700 |
All |
2 Months to 15 Months (Child) |
NCT00247091 |
GR059114MA |
|
May 2000 |
|
September 2004 |
November 1, 2005 |
November 1, 2005 |
|
- Chawama Clinic
Lusaka, Zambia
|
|
| 93 |
NCT00097097 |
Completed |
Neonatal Resuscitation in Zambia |
- Asphyxia Neonatorum
- Neonatal Mortality
- Hypoxic Ischemic Encephalopathy
|
- Procedure: Neonatal Resuscitation
|
Interventional
|
Phase 3 |
- NICHD Global Network for Women's and Children's Health
- Global Network for Women's and Children's Health Research
- Bill and Melinda Gates Foundation
- (and 6 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Neonatal mortality at 7 days
- Neonatal mortality due to perinatal asphyxia
- Self efficacy, knowledge, performance, and competence in neonatal resuscitation
- Apgar scores at 5 minutes
|
40000 |
All |
Child, Adult, Older Adult |
NCT00097097 |
GN 03
U01HD043464 |
|
October 2004 |
|
November 2006 |
November 18, 2004 |
July 31, 2014 |
|
- University of Zambia
Lusaka, Zambia
|
|
| 94 |
NCT00067522 |
Unknown † |
Preventing Unplanned Pregnancies in HIV Infected Zambian Couples |
|
- Behavioral: User-independent contraception program
- Behavioral: Future Planning Perspectives program
|
Interventional
|
Not Applicable |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single
- Primary Purpose: Prevention
|
|
5000 |
All |
16 Years to 38 Years (Child, Adult) |
NCT00067522 |
HD40125
1R01HD040125-01A1 |
|
January 2002 |
|
|
August 25, 2003 |
June 29, 2007 |
|
- Zambia Emory HIV Research Project
Lusaka, Zambia
|
|
| 95 |
NCT03297216 |
Recruiting |
Improving Pregnancy Outcomes With Progesterone |
- Pre-term Birth
- HIV-1-infection
|
|
Interventional
|
Phase 3 |
- University of North Carolina, Chapel Hill
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- AMAG Pharmaceuticals, Inc.
- Bill and Melinda Gates Foundation
|
Other / NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Deliveries or stillbirths before 37 weeks gestation
|
800 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03297216 |
17-1173
1R01HD087119 |
IPOP |
February 7, 2018 |
January 2020 |
December 2020 |
September 29, 2017 |
February 13, 2018 |
|
- Kamwala District Clinic
Lusaka, Zambia - University Teaching Hospital
Lusaka, Zambia
|
|
| 96 |
NCT03132285 |
Completed |
Safety and Acceptability Study of PrePex Device When Removing the Foreskin Shortly After Placement of Device |
|
|
Interventional
|
Not Applicable |
- Ministry of Health, Zambia
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of incidents related to the change in procedure
- Acceptability of the changes procedure to patients
- Effect of the change in procedure on circumcision healing time
|
500 |
Male |
13 Years to 49 Years (Child, Adult) |
NCT03132285 |
0001 |
|
March 11, 2017 |
April 22, 2017 |
June 17, 2017 |
April 27, 2017 |
September 7, 2017 |
|
- Matero Main Clinic
Lusaka, Lusaka province, Zambia - Dambwa North Clinic
Livingstone, Zambia
|
|
| 97 |
NCT02744586 |
Completed |
Zambia One Love Aim 3 Trial |
- HIV
- Sexually Transmitted Diseases
- Neglected Diseases
- Non-communicable Diseases
|
- Behavioral: Strengthening Our Vows (SOV)
- Behavioral: Good Health Package Plus (GHPP)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- HIV Incidence Rate
- Syphilis Incidence Rate
- Vaginal Trichomoniasis Incidence Rate
- (and 12 more...)
|
3450 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02744586 |
IRB00083001 |
|
January 2016 |
December 2016 |
December 2016 |
April 20, 2016 |
February 1, 2018 |
|
- Ndola Research Site
Ndola, Copperbelt, Zambia - Lusaka Research Site
Lusaka, Zambia
|
|
| 98 |
NCT02738892 |
Recruiting |
Zambian Prematurity Prevention Study |
- Pregnancy
- Stillbirth
- Preterm Birth
|
|
Observational
|
|
- University of North Carolina, Chapel Hill
- Global Alliance to Prevent Prematurity and Stillbirth
- Bill and Melinda Gates Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Rate of preterm births per 100 person years
|
4000 |
Female |
18 Years to 50 Years (Adult) |
NCT02738892 |
14-2113 |
|
August 2015 |
November 2018 |
January 2019 |
April 14, 2016 |
October 12, 2018 |
|
- Kamwala Health Centre
Lusaka, Zambia - University Teaching Hospital
Lusaka, Zambia
|
|
| 99 |
NCT02589678 |
Completed |
Zambia SiVET MMR Tdap-IPV |
|
- Biological: Tdap - IPV Vaccine
- Biological: MMR Vaccine
|
Interventional
|
Phase 1
Phase 2 |
- Emory University
- International AIDS Vaccine Initiative
- Zambia-Emory HIV Research Project
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Screening
|
- Number of participants retained
- Number of participants who receive 1 Vaccine
- Number of participants who receive both vaccines
- (and 4 more...)
|
160 |
Female |
18 Years to 40 Years (Adult) |
NCT02589678 |
IRB00080202 |
SiVET |
August 2015 |
May 16, 2017 |
May 16, 2017 |
October 28, 2015 |
November 6, 2017 |
|
- Zambia Emory HIV Research Project
Lusaka, Zambia - Zambia Emory HIV Research Project
Ndola, Zambia
|
|
| 100 |
NCT02242565 |
Completed |
Safety and Effectiveness of Different ShangRing Device Sizes for Adult Male Circumcision in Lusaka, Zambia |
|
|
Interventional
|
Not Applicable |
- FHI 360
- Bill and Melinda Gates Foundation
- Ministry of Health, Zambia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Percentage and 95% confidence interval of men with at least one moderate or severe adverse event.
- Percentage of men who cannot be properly fitted with a ShangRing device
- Evaluate the acceptability of ShangRing procedures among participants and providers
- Percentage of men with complete healing at 42 days
|
500 |
Male |
18 Years to 49 Years (Adult) |
NCT02242565 |
576424
010-04-14 |
|
October 2014 |
September 2015 |
December 2015 |
September 17, 2014 |
October 2, 2017 |
|
- Chilenje Urban Health Centre
Lusaka, Zambia - The University Teaching Hospital (UTH)
Lusaka, Zambia
|
|
Create an RSS feed from your search for:
Download the search results for: