The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI
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|ClinicalTrials.gov Identifier: NCT03883308|
Recruitment Status : Recruiting
First Posted : March 20, 2019
Last Update Posted : January 18, 2020
|Condition or disease||Intervention/treatment||Phase|
|Mild Cognitive Impairment||Behavioral: Multi-domain cognitive training Behavioral: Cross-word puzzle training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI|
|Actual Study Start Date :||October 30, 2017|
|Estimated Primary Completion Date :||September 30, 2020|
|Estimated Study Completion Date :||February 28, 2021|
Treatment group will receive 6 months of online, computerized, multi-domain cognitive training at home.
Behavioral: Multi-domain cognitive training
The cognitive exercises are designed to train executive functions and memory.
Active Comparator: Active Control
The Active Control group will receive 6 months of online, computerized cross-word puzzles at home using the same platform as for the Treatment group.
Behavioral: Cross-word puzzle training
The active control group will be asked to complete a variety of crossword puzzles using the same curriculum assigned to the TG group.
- Executive function composite score [ Time Frame: 6 months ]The primary behavioral outcome is executive function composite score that combines measures of working memory, inhibition, set-shifting, and fluency
- Executive function network connectivity [ Time Frame: 6 months ]The primary neuroimaging outcome is the interconnectivity of the frontal-striatal-parietal network.
- Memory function composite score [ Time Frame: 6 months ]Memory function composite score that combines measures of auditory verbal learning and episodic memory
- Medial temporal network connectivity [ Time Frame: 6 months ]Regional interconnectivity and centrality in medial temporal network
- White matter integrity in memory circuit [ Time Frame: 6 months ]White matter integrity in posterior cingulate-medial temporal-frontal pathways
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03883308
|Contact: Hannah Fingerhut, BSfirstname.lastname@example.org|
|Contact: Hadi Hosseini, PhDemail@example.com|
|United States, California|
|Stanford University School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Hadi Hosseini, PhD 650-724-2939 firstname.lastname@example.org|
|Principal Investigator: Hadi Hosseini, PhD|