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Disease Modifying Genes in Severe Asthma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00212537
Recruitment Status : Active, not recruiting
First Posted : September 21, 2005
Last Update Posted : February 10, 2020
Information provided by (Responsible Party):
NYU Langone Health

Brief Summary:
Gene and protein bank to study disease modifying and susceptibility genes and proteins in urban patients with asthma.

Condition or disease

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Study Type : Observational
Estimated Enrollment : 2000 participants
Observational Model: Case-Control
Time Perspective: Other
Official Title: Disease Modifying Genes in Severe Asthma
Actual Study Start Date : April 8, 2002
Actual Primary Completion Date : January 13, 2011
Estimated Study Completion Date : May 2022

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. To recruit and characterize a cohort of subjects with asthma who reside in a high pollution, high asthma risk neighborhood [ Time Frame: five yeARS ]

Biospecimen Retention:   Samples With DNA
The total amount of blood drawn is approximately 5 tablespoons (75 ml). The blood sample will be processed to isolate "genetic material" (mainly DNA, RNA and protein). This genetic material will be used to try to identify the "genetic factors" or genes that a person inherits that make him or her more likely to develop asthma. The blood is used to test for allergies to weeds, trees, insects and molds (RAST) and a complete blood count.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All individuals approached for participation in the Research Registry shall be able to read or comprehend English. Since participation in the Research Registry does not involve a risk of physical harm, women of childbearing potential will not be queried as to pregnancy status or tested for pregnancy unless they are requested to undergo a methacholine challenge test. There are no additional inclusion/exclusion criteria.

Inclusion Criteria:

  • Ages 18 and above

Exclusion Criteria:

  • Greater than 10 pack year tobacco history
  • Lung diseases other than asthma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00212537

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United States, New York
NYU School of Medicine
New York, New York, United States, 10016
Sponsors and Collaborators
NYU Langone Health
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Principal Investigator: Joan Reibman, MD NYU School of Medicine
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: NYU Langone Health Identifier: NCT00212537    
Other Study ID Numbers: H9698
First Posted: September 21, 2005    Key Record Dates
Last Update Posted: February 10, 2020
Last Verified: February 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by NYU Langone Health:
Asthma and normal
Additional relevant MeSH terms:
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Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases