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Genetic Registry for Rheumatoid Arthritis (NARAC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00069472
Recruitment Status : Completed
First Posted : September 29, 2003
Last Update Posted : September 10, 2015
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
Information provided by (Responsible Party):
Peter Gregersen, Northwell Health

Brief Summary:
Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

Condition or disease
Rheumatoid Arthritis

Detailed Description:

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

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Study Type : Observational
Actual Enrollment : 1062 participants
Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Genetics of Rheumatoid Arthritis Registry
Study Start Date : October 2002
Actual Primary Completion Date : August 2015
Actual Study Completion Date : August 2015

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Genetic Association with risk for rheumatoid arthritis [ Time Frame: 10 years ]
    The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families

Biospecimen Retention:   Samples With DNA
DNA, plasma, serum and cells

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Persons with RA who have two living biological parents. Parents can be affected or unaffected with RA. We call the family units "trios".

Inclusion Criteria:

  • Adult onset RA
  • Diagnosis of RA made between 18 and 60 years old
  • Both parents alive and willing to participate
  • Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

  • Inflammatory bowel disease
  • Lupus
  • Psoriatic arthritis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00069472

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United States, New York
Feinstein Institute for Medical Research
Manhasset, New York, United States, 11030
Sponsors and Collaborators
Northwell Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
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Principal Investigator: Peter K. Gregersen, MD North Shore University Hospital

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Responsible Party: Peter Gregersen, Center Head, Robert S Boas Center for Genomics and Human Genetics, Northwell Health Identifier: NCT00069472    
Other Study ID Numbers: NIAMS-107
N01AR72232-001 ( U.S. NIH Grant/Contract )
First Posted: September 29, 2003    Key Record Dates
Last Update Posted: September 10, 2015
Last Verified: September 2015
Keywords provided by Peter Gregersen, Northwell Health:
Additional relevant MeSH terms:
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Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases