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MIPOMERSEN (19 records)
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1 | NCT01598948 | Completed | Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis |
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Interventional |
Phase 3 |
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Other |
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17 | All | 18 Years and older (Adult, Older Adult) | NCT01598948 | MICA | MICA | August 2012 | May 2015 | June 2015 | May 15, 2012 | September 2, 2015 |
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2 | NCT00477594 | Completed Has Results |
Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia |
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Interventional |
Phase 2 |
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Industry |
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21 | All | 12 Years and older (Child, Adult, Older Adult) | NCT00477594 | 301012-CS17 2007-001024-12 |
May 2007 | March 2011 | July 2011 | May 24, 2007 | September 9, 2016 | April 5, 2013 |
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3 | NCT01414881 | Completed | Study to Assess the Effects of Mipomersen on Lipid and Lipoprotein Metabolism in Healthy Subjects |
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Interventional |
Phase 1 |
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Industry |
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20 | All | 18 Years to 75 Years (Adult, Older Adult) | NCT01414881 | MIPO1600810 | September 2011 | June 2012 | November 2012 | August 11, 2011 | August 3, 2016 |
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4 | NCT00607373 | Completed Has Results |
Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia |
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Interventional |
Phase 3 |
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Industry |
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51 | All | 12 Years and older (Child, Adult, Older Adult) | NCT00607373 | 301012CS5 2005-003449-15 |
RADICHOL 1 | July 2007 | March 2009 | March 2009 | February 5, 2008 | September 9, 2016 | March 21, 2013 |
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5 | NCT00770146 | Completed Has Results |
Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients |
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Interventional |
Phase 3 |
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Industry |
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158 | All | 18 Years and older (Adult, Older Adult) | NCT00770146 | 301012-CS12 | November 2008 | May 2010 | October 2010 | October 9, 2008 | September 9, 2016 | March 20, 2013 |
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6 | NCT00694109 | Completed Has Results |
An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia |
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Interventional |
Phase 3 |
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Industry |
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144 | All | 12 Years and older (Child, Adult, Older Adult) | NCT00694109 | 301012-CS6 2005-003450-10 |
April 2008 | September 2014 | September 2014 | June 10, 2008 | September 9, 2016 | December 21, 2015 |
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7 | NCT01133366 | Completed | A Study to Determine the Effects of Multiple Doses of Mipomersen (200 mg SC) on the Pharmacodynamics and Pharmacokinetics of Single-dose Warfarin |
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Interventional |
Phase 1 |
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Industry |
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18 | All | 18 Years to 45 Years (Adult) | NCT01133366 | MIPO2900509 | May 2010 | May 2010 | July 2010 | May 28, 2010 | August 3, 2016 |
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8 | NCT00794664 | Completed Has Results |
Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis |
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Interventional |
Phase 3 |
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Industry |
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58 | All | 18 Years and older (Adult, Older Adult) | NCT00794664 | MIPO3500108 2008-006020-53 |
January 2009 | May 2010 | October 2010 | November 20, 2008 | September 9, 2016 | March 21, 2013 |
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9 | NCT01475825 | Completed | A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol |
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Interventional |
Phase 3 |
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Industry |
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310 | All | 18 Years and older (Adult, Older Adult) | NCT01475825 | MIPO3801011 2011-001480-42 EFC12875 |
FOCUS FH | December 2011 | February 2016 | February 2016 | November 21, 2011 | August 3, 2016 |
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10 | NCT01061814 | Completed | A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers |
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Interventional |
Phase 1 |
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Industry |
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84 | All | 18 Years to 75 Years (Adult, Older Adult) | NCT01061814 | MIPO3200309 | January 2010 | March 2010 | June 2010 | February 3, 2010 | August 3, 2016 |
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11 | NCT01299298 | Completed | A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of Mipomersen in Japanese Healthy Volunteers |
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Interventional |
Phase 1 |
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Industry |
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20 | Male | 20 Years to 45 Years (Adult) | NCT01299298 | MIPO3700710 2010-021948-18 |
January 2011 | April 2011 | April 2011 | February 18, 2011 | August 3, 2016 |
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12 | NCT00706849 | Completed Has Results |
Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease |
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Interventional |
Phase 3 |
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Industry |
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124 | All | 18 Years and older (Adult, Older Adult) | NCT00706849 | 301012-CS7 | RADICHOL II | July 2008 | December 2009 | May 2010 | June 30, 2008 | September 9, 2016 | March 21, 2013 |
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13 | NCT01090661 | Completed | A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects |
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Interventional |
Phase 1 |
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Industry |
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60 | All | 18 Years to 45 Years (Adult) | NCT01090661 | MIPO2800209 | March 2010 | May 2010 | May 2010 | March 22, 2010 | August 3, 2016 |
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14 | NCT00707746 | Completed Has Results |
Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects |
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Interventional |
Phase 2 |
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Industry |
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34 | All | 18 Years and older (Adult, Older Adult) | NCT00707746 | 301012-CS19 2007-005140-24 |
ASSIST | October 2008 | August 2010 | January 2011 | July 1, 2008 | September 9, 2016 | April 5, 2013 |
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15 | NCT00362180 | Completed Has Results |
Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration |
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Interventional |
Phase 2 |
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Industry |
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38 | All | 18 Years to 65 Years (Adult, Older Adult) | NCT00362180 | 301012-CS10 2005-005783-90 |
July 2006 | March 2010 | September 2010 | August 9, 2006 | October 21, 2016 | June 24, 2015 |
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16 | NCT00281008 | Completed | Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy |
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Interventional |
Phase 2 |
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Industry |
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44 | All | 18 Years and older (Adult, Older Adult) | NCT00281008 | 301012CS9 2005-004797-24 |
February 2006 | July 2007 | December 2007 | January 24, 2006 | August 3, 2016 |
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17 | NCT00280995 | Completed | Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy |
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Interventional |
Phase 2 |
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Industry |
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12 | All | 18 Years and older (Adult, Older Adult) | NCT00280995 | 301012CS8 EudraCT No.: 2005-004796-38 |
January 2006 | April 2007 | August 2007 | January 24, 2006 | August 3, 2016 |
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18 | NCT00231569 | Completed | Dose-escalating Safety Study in Subjects on Stable Statin Therapy |
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Interventional |
Phase 2 |
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Industry |
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74 | All | 18 Years to 65 Years (Adult, Older Adult) | NCT00231569 | 301012CS4 EudraCT No.: 2005-002119-26 |
September 2005 | June 2007 | December 2007 | October 4, 2005 | August 3, 2016 |
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19 | NCT00216463 | Completed | Safety and Tolerability of Varying Load and Dose of ISIS 301012 in People With Elevated LDL-cholesterol Levels |
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Interventional |
Phase 2 |
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Industry |
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50 | All | 18 Years to 65 Years (Adult, Older Adult) | NCT00216463 | 301012CS3 EudraCT No.: 2004-003934-32 |
August 2005 | March 2007 | August 2007 | September 22, 2005 | August 3, 2016 |
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† Study has passed its completion date and status has not been verified in more than two years.