Inclusion criteria:

• Histologically confirmed non-small cell lung cancer (NSCLC)
• At least one prior platinum-based doublet anti-cancer treatment for recurrent or advanced NSCLC
• Disease progression during or after the last anti-cancer therapy
• Eastern Cooperative Oncology Group (ECOG) performance status </= 2
• Serum creatinine </= 2.0 mg/dL or creatinine clearance ?40 mL/min according to Cockcroft and Gault formula:
• Absolute neutrophil count >/= 1.5 x 109/L, hemoglobin >/= 10 g/dL (can be corrected by growth factor or transfusion), and platelet count >/=100 x 109/L
• Total bilirubin </= 1.5 times the upper limit of normal (ULN) and alkaline phosphatase (AP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)</= 3 times ULN (in the case of liver metastases </=5 times ULN). In case AP is > 3 times ULN (in absence of liver metastases) or > 5 times ULN (in presence of liver metastases) AND subject also is known to have bone metastases, the liver specific AP must be separated from the total and used to assess the liver function instead of the total AP.

• At least one lesion of >/=1.5 cm in longest diameter for non-lymph nodes or >/=1.5 cm in shortest diameter for lymph nodes which is serially measurable according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.17

  • Males and females, age >/= 18 years
  • Provide written informed consent
  • Are willing and able to comply with all aspects of the protocol
  • Females of childbearing potential must have a negative serum beta-human chorionic gonadotropin (Beta-hCG) at Visit 1 (Screening) and a negative urine pregnancy test prior to starting study drug (Visit 2). Female subjects of childbearing potential must agree to be abstinent or to use highly effective methods of contraception (eg, condom + spermicide, condom + diaphragm with spermicide, intrauterine device (IUD), or have a vasectomised partner) having starting for at least one menstrual cycle prior to starting study drugs and throughout the entire study period and for 30 days (longer if appropriate) after the last dose of study drug. Those women using hormonal contraceptives must also be using an additional approved method of contraception (as described previously). Perimenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
• Male subjects who are not abstinent or have not undergone a successful vasectomy, who are partners of women of childbearing potential must use, or their partners must use a highly effective method of contraception (eg, condom + spermicide, condom + diaphragm with spermicide, IUD) starting for at least one menstrual cycle prior to starting study drugs and throughout the entire study period and for 30 days (longer if appropriate) after the last dose of study drug. Those with partners using hormonal contraceptives must also be using an additional approved method of contraception (as described previously).

Exclusion criteria:

• Prior therapy with eribulin or an tyrosine kinase inhibitor of the epidermal growth factor receptor
• Subjects with brain or subdural metastases are not eligible, unless they have completed local therapy and have discontinued steroids for this indication for >/= 4 weeks before starting study treatment. Symptoms attributed to brain metastases must be stable for >/= 4 weeks before starting study treatment; radiographic stability should be determined by comparing contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) brain scan performed during screening to a prior scan performed 4 weeks earlier.
• Existing anti-cancer therapy-related toxicities of grade >/=2, other than any grade of alopecia or grade </= 2 neuropathy, which are acceptable
• Current smokers who will not stop smoking one week prior to treatment and during the study
• History of congestive heart failure with New York Heart Association (NYHA) Grade > II, unstable angina, myocardial infarction within the past 6 months, serious cardiac arrhythmia
• Electrocardiogram with QTc interval >/=500 msec based upon Bazett's formula (QTcB)
• Females who are pregnant (positive Beta-hCG test) or breastfeeding
• Subject with hypersensitivity to eribulin and /or erlotinib or any of the excipients
• Presence of a progressive central nervous system (CNS) disease, including degenerative CNS diseases and progressive tumors
• Subjects who are known to be human immunodeficiency virus (HIV) positive, because the neutropenia caused by the study treatments may make such subjects particularly susceptible to infection
• Subjects with active viral hepatitis (A, B, or C) as demonstrated by positive serology
• Radiotherapy, chemotherapy, biological therapy or investigational agents within 2 weeks prior to start of study treatment
• Meningeal carcinomatosis
• History of drug or alcohol dependency or abuse within approximately the last 2 years
• Medically unfit to receive the study drug or unsuitable for any other reason according to investigator judgment
• Any history of or concomitant medical condition that, in the opinion of the Investigator, would compromise the subject's ability to safely complete the study
• Major surgery within 4 weeks before starting study treatment or scheduled for surgery during the projected course of the study