Intravenous Administration of Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery

This study has been completed.

First Received on October 31, 2008. Last Updated on November 23, 2011 History of Changes

Sponsor:	Kuopio University Hospital
Collaborators:	Oulu University Hospital Hospital Cordia, Kuopio, Finland
Information provided by (Responsible Party):	Jari Halonen, Kuopio University Hospital
ClinicalTrials.gov Identifier:	NCT00783900

Purpose

The aim of the study is to compare the effectiviness of biatrial pacing versus intravenous administration of metoprolol in the prevention of atrial fibrillation after cardiac surgery

Condition	Intervention	Phase
Atrial Fibrillation Biatrial Pacing Metoprolol	Other: metoprolol, biatrial pacing	Phase IV

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Prevention
Official Title:	Intravenous Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery

Resource links provided by NLM:

Genetics Home Reference related topics: Brugada syndrome familial atrial fibrillation short QT syndrome

MedlinePlus related topics: Atrial Fibrillation Heart Surgery

Drug Information available for: Metoprolol Metoprolol Tartrate Metoprolol succinate Metoprolol fumarate

U.S. FDA Resources

Further study details as provided by Kuopio University Hospital:

Primary Outcome Measures:

biatriac pacing [ Time Frame: 48 hours ] [ Designated as safety issue: No ]
Incidence of atrial fibrillation [ Time Frame: 48 hours ] [ Designated as safety issue: No ]

Enrollment:	316
Study Start Date:	January 2007
Study Completion Date:	December 2009
Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Active Comparator: metoprolol	Other: metoprolol, biatrial pacing Prevention, atrial fibrillation, cardiac surgery, biatrial pacing, metoprolol
Active Comparator: biatrial pacing	Other: metoprolol, biatrial pacing Prevention, atrial fibrillation, cardiac surgery, biatrial pacing, metoprolol

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

elective CABG and aortic valve cardiac patients,
previous use of beta blocker

Exclusion Criteria:

Previous episodes of Atrial fibrillation or flutter,
II or II degree atrioventricular block, uncontrolled heart failure
Sick sinus syndrome

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00783900

Locations

Finland
Halonen Jari
Kuopio, Finland, FIN-70211

Sponsors and Collaborators

Kuopio University Hospital

Oulu University Hospital

Hospital Cordia, Kuopio, Finland

More Information

No publications provided

Responsible Party:	Jari Halonen, MD, PhD, Kuopio University Hospital
ClinicalTrials.gov Identifier:	NCT00783900 History of Changes
Other Study ID Numbers:	KUH5204006, Eudra-CT: 2008-006932-36
Study First Received:	October 31, 2008
Last Updated:	November 23, 2011
Health Authority:	Finland: Finnish Medicines Agency; Finland: Researc Ethics Committee, Hospital District of Northern Savo

Keywords provided by Kuopio University Hospital:

Prevention

Additional relevant MeSH terms:

Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Metoprolol
Metoprolol succinate
Anti-Arrhythmia Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions

Antihypertensive Agents
Sympatholytics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on February 09, 2012